Ming Shen1,2, Qilin Zhang1,2, Wenjuan Liu2,3, Meng Wang3,4, Jingjing Zhu2,5, Zengyi Ma1,2, Wenqiang He1,2, Shiqi Li1,2, Xuefei Shou1,2, Yiming Li2,3, Zhaoyun Zhang2,3, Hongying Ye2,3, Min He2,3, Bin Lu2,3, Zhenwei Yao2,6, Yun Lu7, Nidan Qiao1,2, Zhao Ye1,2, Yichao Zhang1,2, Yeping Yang2,3, Yao Zhao8,9, Yongfei Wang10,11. 1. Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqi Zhong Road, Shanghai, 200040, China. 2. Shanghai Pituitary Tumor Center, Shanghai, China. 3. Department of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. 4. Division of Endocrinology, the Second Affiliated Hospital, Soochow University, Suzhou, China. 5. Department of Neuropathology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. 6. Department of Radiology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. 7. Department of Nuclear Medicine, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. 8. Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqi Zhong Road, Shanghai, 200040, China. zhaoyaohs@vip.sina.com. 9. Shanghai Pituitary Tumor Center, Shanghai, China. zhaoyaohs@vip.sina.com. 10. Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqi Zhong Road, Shanghai, 200040, China. eamns@hotmail.com. 11. Shanghai Pituitary Tumor Center, Shanghai, China. eamns@hotmail.com.
Abstract
INTRODUCTION: The difficulty of predicting the efficacy of somatostatin analogs (SSA) is not fully resolved. Here, we quantitatively evaluated the predictive value of relative signal intensity (rSI) on T1- and T2-weighted magnetic resonance imaging (MRI) for the short-term efficacy (3 months) of SSA therapy in patients with active acromegaly and assessed the correlation between MRI rSI and expression of somatostatin receptors (SSTR). METHODS: This was a retrospective review of prospectively recorded data. Ninety-two newly diagnosed patients (37 males and 55 females) with active acromegaly were recruited. All patients were treated with pre-surgical SSA, followed by reassessment and transspenoidal surgery. rSI values were generated by calculating the ratio of SI in the tumor to the SI of normal frontal white matter. The Youden indices were calculated to determine the optimal cutoff of rSI to determine the efficacy of SSA. The correlation between rSI and expression of SSTR2/5 was analyzed by the Spearman rank correlation coefficient. RESULTS: T2 rSI was strongly correlated with biochemical sensitivity to SSA. The cutoff value of T2 rSI to distinguish biochemical sensitivity was 1.205, with a positive predictive value (PPV) of 81.5 % and a negative predictive value (NPV) of 77.3 %. No correlation was found between MRI and tumor size sensitivity. Moreover, T2 rSI was negatively correlated with the expression of SSTR5. CONCLUSION: T2 rSI correlates with the expression of SSTR5 and quantitatively predicts the biochemical efficacy of SSA in acromegaly.
INTRODUCTION: The difficulty of predicting the efficacy of somatostatin analogs (SSA) is not fully resolved. Here, we quantitatively evaluated the predictive value of relative signal intensity (rSI) on T1- and T2-weighted magnetic resonance imaging (MRI) for the short-term efficacy (3 months) of SSA therapy in patients with active acromegaly and assessed the correlation between MRI rSI and expression of somatostatin receptors (SSTR). METHODS: This was a retrospective review of prospectively recorded data. Ninety-two newly diagnosed patients (37 males and 55 females) with active acromegaly were recruited. All patients were treated with pre-surgical SSA, followed by reassessment and transspenoidal surgery. rSI values were generated by calculating the ratio of SI in the tumor to the SI of normal frontal white matter. The Youden indices were calculated to determine the optimal cutoff of rSI to determine the efficacy of SSA. The correlation between rSI and expression of SSTR2/5 was analyzed by the Spearman rank correlation coefficient. RESULTS: T2 rSI was strongly correlated with biochemical sensitivity to SSA. The cutoff value of T2 rSI to distinguish biochemical sensitivity was 1.205, with a positive predictive value (PPV) of 81.5 % and a negative predictive value (NPV) of 77.3 %. No correlation was found between MRI and tumor size sensitivity. Moreover, T2 rSI was negatively correlated with the expression of SSTR5. CONCLUSION: T2 rSI correlates with the expression of SSTR5 and quantitatively predicts the biochemical efficacy of SSA in acromegaly.
Entities:
Keywords:
Acromegaly; Magnetic resonance imaging; Relative signal intensity; Somatostatin analog; Somatostatin receptor
Authors: Laurence Katznelson; John L D Atkinson; David M Cook; Shereen Z Ezzat; Amir H Hamrahian; Karen K Miller Journal: Endocr Pract Date: 2011 Jul-Aug Impact factor: 3.443
Authors: S Melmed; A Colao; A Barkan; M Molitch; A B Grossman; D Kleinberg; D Clemmons; P Chanson; E Laws; J Schlechte; M L Vance; K Ho; A Giustina Journal: J Clin Endocrinol Metab Date: 2009-02-10 Impact factor: 5.958
Authors: Amy A Swanson; Dana Erickson; Diane Mary Donegan; Sarah M Jenkins; Jamie J Van Gompel; John L D Atkinson; Bradley J Erickson; Caterina Giannini Journal: Pituitary Date: 2020-10-19 Impact factor: 4.107
Authors: María R Alhambra-Expósito; Alejandro Ibáñez-Costa; Paloma Moreno-Moreno; Esther Rivero-Cortés; Mari C Vázquez-Borrego; Cristóbal Blanco-Acevedo; Álvaro Toledano-Delgado; María S Lombardo-Galera; Juan A Vallejo-Casas; Manuel D Gahete; Justo P Castaño; María A Gálvez; Raúl M Luque Journal: Sci Rep Date: 2018-04-18 Impact factor: 4.379