Literature DB >> 27514803

Assessing the Biological Activity of the Glucan Phosphatase Laforin.

Carlos Romá-Mateo1,2, Madushi Raththagala3, Mathew S Gentry3, Pascual Sanz4,5.   

Abstract

Glucan phosphatases are a recently discovered family of enzymes that dephosphorylate either starch or glycogen and are essential for proper starch metabolism in plants and glycogen metabolism in humans. Mutations in the gene encoding the only human glucan phosphatase, laforin, result in the fatal, neurodegenerative, epilepsy known as Lafora disease. Here, we describe phosphatase assays to assess both generic laforin phosphatase activity and laforin's unique glycogen phosphatase activity.

Entities:  

Keywords:  Dual-specificity phosphatase; Glycogen; Lafora disease

Mesh：

Substances：

Year:  2016        PMID： 27514803      PMCID： PMC5339740          DOI： 10.1007/978-1-4939-3746-2_7

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  28 in total

1.  Assays for protein-tyrosine phosphatases.

Authors:  Daniel F McCain; Zhong-Yin Zhang
Journal:  Methods Enzymol       Date:  2002       Impact factor: 1.600

2.  Mutation spectrum and predicted function of laforin in Lafora's progressive myoclonus epilepsy.

Authors:  B A Minassian; L Ianzano; M Meloche; E Andermann; G A Rouleau; A V Delgado-Escueta; S W Scherer
Journal:  Neurology       Date:  2000-08-08       Impact factor: 9.910

Review 3.  Protein tyrosine phosphatases: from genes, to function, to disease.

Authors:  Nicholas K Tonks
Journal:  Nat Rev Mol Cell Biol       Date:  2006-11       Impact factor: 94.444

4.  A bioassay for Lafora disease and laforin glucan phosphatase activity.

Authors:  Amanda R Sherwood; Mary Beth Johnson; Antonio V Delgado-Escueta; Matthew S Gentry
Journal:  Clin Biochem       Date:  2013-09-06       Impact factor: 3.281

5.  Molecular characterization of laforin, a dual-specificity protein phosphatase implicated in Lafora disease.

Authors:  Jean-Marie Girard; K H Diêp Lê; Florence Lederer
Journal:  Biochimie       Date:  2006-09-14       Impact factor: 4.079

6.  Mechanism of inhibition of protein-tyrosine phosphatases by vanadate and pervanadate.

Authors:  G Huyer; S Liu; J Kelly; J Moffat; P Payette; B Kennedy; G Tsaprailis; M J Gresser; C Ramachandran
Journal:  J Biol Chem       Date:  1997-01-10       Impact factor: 5.157

7.  Glycogen phosphomonoester distribution in mouse models of the progressive myoclonic epilepsy, Lafora disease.

Authors:  Anna A DePaoli-Roach; Christopher J Contreras; Dyann M Segvich; Christian Heiss; Mayumi Ishihara; Parastoo Azadi; Peter J Roach
Journal:  J Biol Chem       Date:  2014-11-21       Impact factor: 5.157

8.  Regulation of glycogen synthesis by the laforin-malin complex is modulated by the AMP-activated protein kinase pathway.

Authors:  Maria Carmen Solaz-Fuster; José Vicente Gimeno-Alcañiz; Susana Ros; Maria Elena Fernandez-Sanchez; Belen Garcia-Fojeda; Olga Criado Garcia; David Vilchez; Jorge Dominguez; Mar Garcia-Rocha; Maribel Sanchez-Piris; Carmen Aguado; Erwin Knecht; Jose Serratosa; Joan Josep Guinovart; Pascual Sanz; Santiago Rodriguez de Córdoba
Journal:  Hum Mol Genet       Date:  2007-11-20       Impact factor: 6.150

9.  Laforin is a glycogen phosphatase, deficiency of which leads to elevated phosphorylation of glycogen in vivo.

Authors:  Vincent S Tagliabracci; Julie Turnbull; Wei Wang; Jean-Marie Girard; Xiaochu Zhao; Alexander V Skurat; Antonio V Delgado-Escueta; Berge A Minassian; Anna A Depaoli-Roach; Peter J Roach
Journal:  Proc Natl Acad Sci U S A       Date:  2007-11-26       Impact factor: 11.205

10.  Dimerization of the glucan phosphatase laforin requires the participation of cysteine 329.

Authors:  Pablo Sánchez-Martín; Madushi Raththagala; Travis M Bridges; Satrio Husodo; Matthew S Gentry; Pascual Sanz; Carlos Romá-Mateo
Journal:  PLoS One       Date:  2013-07-26       Impact factor: 3.240
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