Literature DB >> 17057753

Protein tyrosine phosphatases: from genes, to function, to disease.

Nicholas K Tonks1.   

Abstract

The protein tyrosine phosphatase (PTP) superfamily of enzymes functions in a coordinated manner with protein tyrosine kinases to control signalling pathways that underlie a broad spectrum of fundamental physiological processes. In this review, I describe recent breakthroughs in our understanding of the role of the PTPs in the regulation of signal transduction and the aetiology of human disease.

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Year:  2006        PMID： 17057753     DOI： 10.1038/nrm2039

Source DB:  PubMed          Journal:  Nat Rev Mol Cell Biol        ISSN： 1471-0072            Impact factor:   94.444


  643 in total

1.  DUSP4 regulates neuronal differentiation and calcium homeostasis by modulating ERK1/2 phosphorylation.

Authors:  Sun Young Kim; Yong-Mahn Han; Mihee Oh; Won-Kon Kim; Kyoung-Jin Oh; Sang Chul Lee; Kwang-Hee Bae; Baek-Soo Han
Journal:  Stem Cells Dev       Date:  2014-12-23       Impact factor: 3.272

2.  H2S-Induced sulfhydration of the phosphatase PTP1B and its role in the endoplasmic reticulum stress response.

Authors:  Navasona Krishnan; Cexiong Fu; Darryl J Pappin; Nicholas K Tonks
Journal:  Sci Signal       Date:  2011-12-13       Impact factor: 8.192

3.  Inhibition of hematopoietic protein tyrosine phosphatase augments and prolongs ERK1/2 and p38 activation.

Authors:  Eduard Sergienko; Jian Xu; Wallace H Liu; Russell Dahl; David A Critton; Ying Su; Brock T Brown; Xochella Chan; Li Yang; Ekaterina V Bobkova; Stefan Vasile; Hongbin Yuan; Justin Rascon; Sharon Colayco; Shyama Sidique; Nicholas D P Cosford; Thomas D Y Chung; Tomas Mustelin; Rebecca Page; Paul J Lombroso; Lutz Tautz
Journal:  ACS Chem Biol       Date:  2011-11-17       Impact factor: 5.100

4.  Visualizing active-site dynamics in single crystals of HePTP: opening of the WPD loop involves coordinated movement of the E loop.

Authors:  David A Critton; Lutz Tautz; Rebecca Page
Journal:  J Mol Biol       Date:  2010-11-19       Impact factor: 5.469

Review 5.  Tumour suppressor function of protein tyrosine phosphatase receptor-T.

Authors:  Anthony Scott; Zhenghe Wang
Journal:  Biosci Rep       Date:  2011-10       Impact factor: 3.840

6.  Prevention of JNK phosphorylation as a mechanism for rosiglitazone in neuroprotection after transient cerebral ischemia: activation of dual specificity phosphatase.

Authors:  Nobuya Okami; Purnima Narasimhan; Hideyuki Yoshioka; Hiroyuki Sakata; Gab Seok Kim; Joo Eun Jung; Carolina M Maier; Pak H Chan
Journal:  J Cereb Blood Flow Metab       Date:  2012-10-03       Impact factor: 6.200

7.  S-nitrosylated SHP-2 contributes to NMDA receptor-mediated excitotoxicity in acute ischemic stroke.

Authors:  Zhong-Qing Shi; Carmen R Sunico; Scott R McKercher; Jiankun Cui; Gen-Sheng Feng; Tomohiro Nakamura; Stuart A Lipton
Journal:  Proc Natl Acad Sci U S A       Date:  2013-02-04       Impact factor: 11.205

8.  GLEPP1/protein-tyrosine phosphatase phi inhibitors block chemotaxis in vitro and in vivo and improve murine ulcerative colitis.

Authors:  Rosanna Pescini Gobert; Monique van den Eijnden; Cedric Szyndralewiez; Catherine Jorand-Lebrun; Dominique Swinnen; Linfeng Chen; Corine Gillieron; Fiona Pixley; Pierre Juillard; Patrick Gerber; Caroline Johnson-Léger; Serge Halazy; Montserrat Camps; Agnes Bombrun; Margaret Shipp; Pierre-Alain Vitte; Vittoria Ardissone; Chiara Ferrandi; Dominique Perrin; Christian Rommel; Rob Hooft van Huijsduijnen
Journal:  J Biol Chem       Date:  2009-02-20       Impact factor: 5.157

9.  Poliovirus entry into human brain microvascular cells requires receptor-induced activation of SHP-2.

Authors:  Carolyn B Coyne; Kwang S Kim; Jeffrey M Bergelson
Journal:  EMBO J       Date:  2007-08-23       Impact factor: 11.598

10.  Mutational inactivation of PTPRD in glioblastoma multiforme and malignant melanoma.

Authors:  David A Solomon; Jung-Sik Kim; Julia C Cronin; Zita Sibenaller; Timothy Ryken; Steven A Rosenberg; Habtom Ressom; Walter Jean; Darell Bigner; Hai Yan; Yardena Samuels; Todd Waldman
Journal:  Cancer Res       Date:  2008-12-15       Impact factor: 12.701
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