Ramazan Uçar1, Murat Biyik2, Esma Uçar1, İlker Polat3, Sami Çifçi2, Hüseyin Ataseven2, Ali Demir2. 1. Department of Internal Medicine, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey. 2. Department of Gastroenterology, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey. 3. Division of Internal Medicine, Afyon State Hospital, Afyonkarahisar, Turkey.
Abstract
BACKGROUND/AIM: Acute pancreatitis is the most common adverse event of endoscopic retrograde cholangiopancreatography (ERCP). We aimed to evaluate the efficacy of intramuscular diclofenac sodium for prophylaxis of post-ERCP pancreatitis (PEP) in comparison to the rectal form. MATERIALS AND METHODS: One hundred and fifty consecutive patients who underwentERCP were enrolled in this single-center, prospective, randomized controlled study. Patients were randomized into three groups. The first group received 75 mg of diclofenac sodium via intramuscular route and the second group received 100 mg of diclofenac sodium rectally 30-90 min before the procedure. The third group served as the control group. Patients were evaluated for post-ERCP pancreatitis with serum amylase levels and abdominal pain 24 h after the procedure. RESULTS: The overall incidence of PEP was 6% (n = 9) and 2% (n = 1) in the intramuscular (IM) and rectal groups, respectively, and 14% in the control group (P = 0.014). Nineteen (12.7%) patients developed post-ERCP abdominal pain (8% in IM, 10% in rectal, and 20% in control group; P = 0.154). Twenty-five (16.6%) patients developed post-ERCP hyperamylasemia (10% in IM, 12% in rectal, and 24% in control group; P = 0.03). CONCLUSION: Prophylaxis with diclofenac given rectally or intramuscularly is an effective option for the management of post-ERCP pancreatitis.
RCT Entities:
BACKGROUND/AIM: Acute pancreatitis is the most common adverse event of endoscopic retrograde cholangiopancreatography (ERCP). We aimed to evaluate the efficacy of intramuscular diclofenac sodium for prophylaxis of post-ERCP pancreatitis (PEP) in comparison to the rectal form. MATERIALS AND METHODS: One hundred and fifty consecutive patients who underwent ERCP were enrolled in this single-center, prospective, randomized controlled study. Patients were randomized into three groups. The first group received 75 mg of diclofenac sodium via intramuscular route and the second group received 100 mg of diclofenac sodium rectally 30-90 min before the procedure. The third group served as the control group. Patients were evaluated for post-ERCP pancreatitis with serum amylase levels and abdominal pain 24 h after the procedure. RESULTS: The overall incidence of PEP was 6% (n = 9) and 2% (n = 1) in the intramuscular (IM) and rectal groups, respectively, and 14% in the control group (P = 0.014). Nineteen (12.7%) patients developed post-ERCP abdominal pain (8% in IM, 10% in rectal, and 20% in control group; P = 0.154). Twenty-five (16.6%) patients developed post-ERCP hyperamylasemia (10% in IM, 12% in rectal, and 24% in control group; P = 0.03). CONCLUSION: Prophylaxis with diclofenac given rectally or intramuscularly is an effective option for the management of post-ERCP pancreatitis.
Authors: Basile Njei; Thomas R McCarty; Thiruvengadam Muniraj; Prabin Sharma; Priya A Jamidar; Harry R Aslanian; Shyam Varadarajulu; Udayakumar Navaneethan Journal: Endosc Int Open Date: 2020-01-08
Authors: Juan Pablo Román Serrano; José Jukemura; Samuel Galante Romanini; Paúl Fernando Guamán Aguilar; Juliana Silveira Lima de Castro; Isabela Trindade Torres; José Andres Sanchez Pulla; Otavio Micelli Neto; Eloy Taglieri; José Celso Ardengh Journal: World J Gastrointest Endosc Date: 2020-11-16
Authors: Yin Shou-Xin; Han Shuai; Kong Fan-Guo; Dao Xing-Yuan; Huang Jia-Guo; Peng Tao; Qi Lin; Shang Yan-Sheng; Yang Ting-Ting; Zhao Jing; Li Fang; Qi Hao-Liang; Liu Man Journal: Medicine (Baltimore) Date: 2020-10-16 Impact factor: 1.817