Chandrakanth Are1, Sanjib Chowdhury2, Humera Ahmad3, Advaitaa Ravipati4, Tianqiang Song5, Shailesh Shrikandhe6, Lynette Smith7. 1. Division of Surgical Oncology, Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska. care@unmc.edu. 2. Section of Gastroenterology, Department of Medicine, Boston University Medical Center, Boston, Massachusetts. 3. Department of Surgery, Gundersen Medical Foundation, La Crosse, Wisconsin. 4. University of South Florida, Tampa, Florida. 5. Department of Hepatobiliary Tumor, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China. 6. Tata Memorial Hospital, Mumbai, India. 7. College of Public Health, University of Nebraska Medical Center, Omaha, Nebraska.
Abstract
BACKGROUND AND OBJECTIVES: Pancreatic Cancer (PC) is a lethal malignancy that accounts for about 4% of cancer-related deaths worldwide. The aim of this study is to describe the influence of geography (based on WHO regions), socio-economic development (based on Human Development Index [HDI]) and demographic shift on the temporal trends in global incidence and mortality of PC. METHODS: Data (2012-2030) relating to the incidence, mortality of PC and demographic shifts based on WHO regions and HDI areas were extracted from GLOBOCAN 2012. Linear regression was used to evaluate trends in total incidence and mortality. RESULTS: We noted a definite association between PC and higher socio-economic status. Advanced age (age ≥65) contributed to the rising burden in all socio-economic regions of the world except in the Low Human Development (LHD) countries where the disease predominantly affected population <65 years of age. CONCLUSIONS: The global burden of PC is expected to rise significantly over the next few decades regardless of geographic location, socio-economic development, age and gender. Advance knowledge of this data can help formulate strategies to specifically target countries and populations that promote public health policy to tackle this lethal disease on the global stage. J. Surg. Oncol. 2016;114:736-742.
BACKGROUND AND OBJECTIVES:Pancreatic Cancer (PC) is a lethal malignancy that accounts for about 4% of cancer-related deaths worldwide. The aim of this study is to describe the influence of geography (based on WHO regions), socio-economic development (based on Human Development Index [HDI]) and demographic shift on the temporal trends in global incidence and mortality of PC. METHODS: Data (2012-2030) relating to the incidence, mortality of PC and demographic shifts based on WHO regions and HDI areas were extracted from GLOBOCAN 2012. Linear regression was used to evaluate trends in total incidence and mortality. RESULTS: We noted a definite association between PC and higher socio-economic status. Advanced age (age ≥65) contributed to the rising burden in all socio-economic regions of the world except in the Low Human Development (LHD) countries where the disease predominantly affected population <65 years of age. CONCLUSIONS: The global burden of PC is expected to rise significantly over the next few decades regardless of geographic location, socio-economic development, age and gender. Advance knowledge of this data can help formulate strategies to specifically target countries and populations that promote public health policy to tackle this lethal disease on the global stage. J. Surg. Oncol. 2016;114:736-742.
Keywords:
Human Development Index (HDI); WHO regions; demographic shift; global pancreatic cancer burden; predictive trends based on GLOBOCAN 2012 database
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