Literature DB >> 27511289

Evaluation of Substituted 1,2,3-Dithiazoles as Inhibitors of the Feline Immunodeficiency Virus (FIV) Nucleocapsid Protein via a Proposed Zinc Ejection Mechanism.

Christopher R M Asquith1,2, Lidia S Konstantinova3,4, Tuomo Laitinen5, Marina L Meli2, Antti Poso5, Oleg A Rakitin3,4, Regina Hofmann-Lehmann2, Stephen T Hilton6.   

Abstract

A diverse library of 5-thieno-, 5-oxo-, and 5-imino-1,2,3-dithiazole derivatives was synthesized and evaluated for efficacy against the feline immunodeficiency virus (FIV) as a model for HIV in cells. Several diverse compounds from this series displayed nanomolar activity and low toxicity, representing a potential new class of compounds for the treatment of FIV and HIV.
© 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  FIV; HIV-1; homology models; nucleocapsid protein; zinc abstraction; zinc ejection

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Year:  2016        PMID： 27511289     DOI： 10.1002/cmdc.201600260

Source DB:  PubMed          Journal:  ChemMedChem        ISSN： 1860-7179            Impact factor:   3.466


  2 in total

1.  The Conversion of 5,5'-Bi(1,2,3-dithiazolylidenes) into Isothiazolo[5,4-d]isothiazoles.

Authors:  Lidia S Konstantinova; Ilia V Baranovsky; Vlada V Strunyasheva; Andreas S Kalogirou; Vadim V Popov; Konstantin A Lyssenko; Panayiotis A Koutentis; Oleg A Rakitin
Journal:  Molecules       Date:  2018-05-24       Impact factor: 4.411

2.  Synthesis of 2-((2-(Benzo[d]oxazol-2-yl)-2H-imidazol-4-yl)amino)-phenols from 2-((5H-1,2,3-Dithiazol-5-ylidene)amino)phenols through Unprecedented Formation of Imidazole Ring from Two Methanimino Groups.

Authors:  Ilia V Baranovsky; Lidia S Konstantinova; Mikhail A Tolmachev; Vadim V Popov; Konstantin A Lyssenko; Oleg A Rakitin
Journal:  Molecules       Date:  2020-08-19       Impact factor: 4.411
  2 in total

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