| Literature DB >> 27505078 |
Carl J Lacey1, Irene Wohlman2, Christophe Guillon1, Jaya Saxena1, Cynthia Fianu-Velgus1, Erik Aponte1, Sherri C Young3, Diane E Heck4, Laurie B Joseph2, Jeffrey D Laskin5, Ned D Heindel6.
Abstract
The molecular pathology of sulfur mustard injury is complex, with at least nine inflammation-related enzymes and receptors upregulated in the zone of the insult. A new approach wherein inhibitors of these targets have been linked by hydrolyzable bonds, either one to one or via separate preattachment to a carrier molecule, has been shown to significantly enhance the therapeutic response compared with the individual agents. This article reviews the published work of the authors in this drug development domain over the last 8 years.Entities:
Keywords: bifunctionals; chloroethylethylsulfide; inflammation; phorbol ester; skin; sulfur mustard; vesicants
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Year: 2016 PMID： 27505078 PMCID： PMC5063683 DOI： 10.1111/nyas.13177
Source DB: PubMed Journal: Ann N Y Acad Sci ISSN： 0077-8923 Impact factor: 5.691