INTRODUCTION: Impaired endothelial function, as assessed by brachial artery flow-mediated dilation (FMD), is an established risk factor for cardiovascular events. FMD is impaired in heart failure (HF) patients, but less is known about hyperemic brachial artery flow. We investigated the relationship between FMD and hyperemic flow with adverse clinical outcomes in HF patients. METHODS: Brachial artery FMD and hyperemic flow were assessed in 156 patients (70.5 % Male; 45.5% Caucasian; mean age (± SD) = 56.2 (±12.4) years) with HF and reduced left ventricular ejection fraction (LVEF). Cox proportional hazard models were used to assess the potential explanatory association of FMD and hyperemic flow with the composite outcome of death or cardiovascular hospitalization over a median 5-year follow-up period. RESULTS: Both FMD and hyperemic flow were negatively correlated with age, but unrelated to sex, race, body mass index, LVEF or N-terminal pro-B-Type natriuretic peptide (NT-ProBNP). Reduced hyperemic flow, but not FMD, was associated with an increased risk of death or cardiac hospitalization after controlling for traditional risk factors. CONCLUSION: The association of reduced hyperemic flow with increased risk of adverse clinical outcomes suggests that micro-vascular function may be an important prognostic marker in patients with HF.
INTRODUCTION: Impaired endothelial function, as assessed by brachial artery flow-mediated dilation (FMD), is an established risk factor for cardiovascular events. FMD is impaired in heart failure (HF) patients, but less is known about hyperemic brachial artery flow. We investigated the relationship between FMD and hyperemic flow with adverse clinical outcomes in HF patients. METHODS: Brachial artery FMD and hyperemic flow were assessed in 156 patients (70.5 % Male; 45.5% Caucasian; mean age (± SD) = 56.2 (±12.4) years) with HF and reduced left ventricular ejection fraction (LVEF). Cox proportional hazard models were used to assess the potential explanatory association of FMD and hyperemic flow with the composite outcome of death or cardiovascular hospitalization over a median 5-year follow-up period. RESULTS: Both FMD and hyperemic flow were negatively correlated with age, but unrelated to sex, race, body mass index, LVEF or N-terminal pro-B-Type natriuretic peptide (NT-ProBNP). Reduced hyperemic flow, but not FMD, was associated with an increased risk of death or cardiac hospitalization after controlling for traditional risk factors. CONCLUSION: The association of reduced hyperemic flow with increased risk of adverse clinical outcomes suggests that micro-vascular function may be an important prognostic marker in patients with HF.
Authors: Daniela Calderaro; Maristela C Monachini; Carolina L Z Vieira; Pai Ching Yu; Danielle M Gualandro; Andre C Marques; Bruno Caramelli Journal: Arterioscler Thromb Vasc Biol Date: 2008-04 Impact factor: 8.311
Authors: Stuart D Katz; Katarzyna Hryniewicz; Ingrid Hriljac; Kujtim Balidemaj; Clarito Dimayuga; Alhakam Hudaihed; Aleksandr Yasskiy Journal: Circulation Date: 2005-01-17 Impact factor: 29.690
Authors: Andrew Sherwood; Christopher M O'Connor; Faye S Routledge; Alan L Hinderliter; Lana L Watkins; Michael A Babyak; Gary G Koch; Kirkwood F Adams; Carla Sueta Dupree; Patricia P Chang; Benson M Hoffman; Julie Johnson; Margaret Bowers; Kristy S Johnson; James A Blumenthal Journal: J Card Fail Date: 2011-01-21 Impact factor: 5.712
Authors: D S Celermajer; K E Sorensen; V M Gooch; D J Spiegelhalter; O I Miller; I D Sullivan; J K Lloyd; J E Deanfield Journal: Lancet Date: 1992-11-07 Impact factor: 79.321
Authors: Catherine F Notarius; Philip J Millar; Daniel A Keir; Hisayoshi Murai; Nobuhiko Haruki; Emma O'Donnell; Susan Marzolini; Paul Oh; John S Floras Journal: Am J Physiol Regul Integr Comp Physiol Date: 2019-07-31 Impact factor: 3.619
Authors: Kanokwan Bunsawat; Stephen M Ratchford; Jeremy K Alpenglow; Soung Hun Park; Catherine L Jarrett; Josef Stehlik; Stavros G Drakos; Russell S Richardson; D Walter Wray Journal: Exp Physiol Date: 2020-06-18 Impact factor: 2.969
Authors: Patrick J Smith; James A Blumenthal; Alan L Hinderliter; Stephanie M Mabe; Jeanne E Schwartz; Forgive Avorgbedor; Andrew Sherwood Journal: J Hypertens Date: 2019-05 Impact factor: 4.844
Authors: Patrick J Smith; James A Blumenthal; Alan L Hinderliter; Lana L Watkins; Benson M Hoffman; Andrew Sherwood Journal: Am J Geriatr Psychiatry Date: 2018-06-28 Impact factor: 4.105
Authors: Zachary I Grunewald; Francisco I Ramirez-Perez; Makenzie L Woodford; Mariana Morales-Quinones; Salvador Mejia; Camila Manrique-Acevedo; Ulrich Siebenlist; Luis A Martinez-Lemus; Bysani Chandrasekar; Jaume Padilla Journal: Hypertension Date: 2020-08-24 Impact factor: 10.190
Authors: Miles F Bartlett; Andrew Oneglia; Manall Jaffery; Shayla Manitowabi-Huebner; Dennis M Hueber; Michael D Nelson Journal: J Appl Physiol (1985) Date: 2020-09-17
Authors: G P T Areas; A Mazzuco; F R Caruso; R B Jaenisch; R Cabiddu; S A Phillips; R Arena; A Borghi-Silva Journal: Heart Fail Rev Date: 2019-01 Impact factor: 4.214
Authors: Kanokwan Bunsawat; Stephen M Ratchford; Jeremy K Alpenglow; Soung Hun Park; Catherine L Jarrett; Josef Stehlik; Adam S Smith; Russell S Richardson; D Walter Wray Journal: J Appl Physiol (1985) Date: 2020-11-19