Ying Hong1, Nobuyuki Shoji2, Tetsuya Morita3, Kazunori Hirasawa4, Kazuhiro Matsumura3, Masayuki Kasahara5, Kimiya Shimizu3. 1. Department of Ophthalmology, Peking University Third Hospital, Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing 100191, China. 2. Department of Rehabilitation, Orthoptics and Visual Science Course, Kitasato University School of Allied Health Sciences, Sagamihara City 252-0373, Japan; Department of Ophthalmology, Kitasato University Hospital, Sagamihara City 252-0373, Japan. 3. Kitasato University, Sagamihara City 252-0373, Japan. 4. Department of Rehabilitation, Orthoptics and Visual Science Course, Kitasato University School of Allied Health Sciences, Sagamihara City 252-0373, Japan. 5. Department of Ophthalmology, Kitasato University Hospital, Sagamihara City 252-0373, Japan.
Abstract
AIM: To compare the corneal biomechanical properties difference by ocular response analyzer (ORA) in normal tension glaucoma (NTG) patients with different visual field (VF) progression speed. METHODS: NTG patients with well-controlled Goldmann applanation tonometer (GAT) who routinely consulted Kitasato University Hospital Glaucoma Department between January 2010 and February 2014 were enrolled. GAT and ORA parameters including corneal compensated intraocular pressure (IOPcc), Goldmann estimated intraocular pressure (IOPg), corneal hysteresis (CH), corneal resistance factor (CRF) were recorded. VF was tested by Swedish interactive threshold algorithm (SITA)-standard 30-2 fields. All patients underwent VF measurement regularly and GAT did not exceed 15 mm Hg at any time during the 3y follow up. Patients were divided into four groups according to VF change over 3y, and ORA findings were compared between the upper 25(th) percentile group (slow progression group) and the lower 25(th) percentile group (rapid progression group). RESULTS: Eighty-two eyes of 56 patients were studied. There were 21 eyes (21 patients) each in rapid and slow progression groups respectively. GAT, IOPcc, IOPg, CH, CRF were 12.1±1.4 mm Hg, 15.8±1.8 mm Hg, 12.8±2.0 mm Hg, 8.4±1.1 mm Hg, 7.9±1.3 mm Hg respectively in rapid progression group and 11.5±1.3 mm Hg, 13.5±2.1 mm Hg, 11.2±1.6 mm Hg, 9.3±1.1 mm Hg, 8.2±0.9 mm Hg respectively in slow progression group (P=0.214, <0.001, 0.007, 0.017, 0.413, respectively). In bivariate correlation analysis, IOPcc, IOPcc-GAT and CH were significant correlated with mΔMD (r=-0.292, -0.312, 0.228 respectively, P=0.008, 0.004, 0.039 respectively). CONCLUSION: Relatively rapid VF progression occurred in NTG patients whose IOPcc are rather high, CH are rather low and the difference between IOPcc and GAT are relatively large. Higher IOPcc and lower CH are associated with VF progression in NTG patients. This study suggests that GAT measures might underestimate the IOP in such patients.
AIM: To compare the corneal biomechanical properties difference by ocular response analyzer (ORA) in normal tension glaucoma (NTG) patients with different visual field (VF) progression speed. METHODS: NTG patients with well-controlled Goldmann applanation tonometer (GAT) who routinely consulted Kitasato University Hospital Glaucoma Department between January 2010 and February 2014 were enrolled. GAT and ORA parameters including corneal compensated intraocular pressure (IOPcc), Goldmann estimated intraocular pressure (IOPg), corneal hysteresis (CH), corneal resistance factor (CRF) were recorded. VF was tested by Swedish interactive threshold algorithm (SITA)-standard 30-2 fields. All patients underwent VF measurement regularly and GAT did not exceed 15 mm Hg at any time during the 3y follow up. Patients were divided into four groups according to VF change over 3y, and ORA findings were compared between the upper 25(th) percentile group (slow progression group) and the lower 25(th) percentile group (rapid progression group). RESULTS: Eighty-two eyes of 56 patients were studied. There were 21 eyes (21 patients) each in rapid and slow progression groups respectively. GAT, IOPcc, IOPg, CH, CRF were 12.1±1.4 mm Hg, 15.8±1.8 mm Hg, 12.8±2.0 mm Hg, 8.4±1.1 mm Hg, 7.9±1.3 mm Hg respectively in rapid progression group and 11.5±1.3 mm Hg, 13.5±2.1 mm Hg, 11.2±1.6 mm Hg, 9.3±1.1 mm Hg, 8.2±0.9 mm Hg respectively in slow progression group (P=0.214, <0.001, 0.007, 0.017, 0.413, respectively). In bivariate correlation analysis, IOPcc, IOPcc-GAT and CH were significant correlated with mΔMD (r=-0.292, -0.312, 0.228 respectively, P=0.008, 0.004, 0.039 respectively). CONCLUSION: Relatively rapid VF progression occurred in NTG patients whose IOPcc are rather high, CH are rather low and the difference between IOPcc and GAT are relatively large. Higher IOPcc and lower CH are associated with VF progression in NTG patients. This study suggests that GAT measures might underestimate the IOP in such patients.
Entities:
Keywords:
corneal biochemical properties; intraocular pressure; normal tension glaucoma; ocular response analyzer; visual field
Authors: Mauro T Leite; Luciana M Alencar; Charlotte Gore; Robert N Weinreb; Pamela A Sample; Linda M Zangwill; Felipe A Medeiros Journal: Am J Ophthalmol Date: 2010-06-11 Impact factor: 5.258
Authors: Michaël J A Girard; J-K Francis Suh; Michael Bottlang; Claude F Burgoyne; J Crawford Downs Journal: Invest Ophthalmol Vis Sci Date: 2011-07-29 Impact factor: 4.799
Authors: Carlos V Gustavo De Moraes; Victoria Hill; Celso Tello; Jeffrey M Liebmann; Robert Ritch Journal: J Glaucoma Date: 2012 Apr-May Impact factor: 2.503
Authors: David Križaj; Daniel A Ryskamp; Ning Tian; Gülgün Tezel; Claire H Mitchell; Vladlen Z Slepak; Valery I Shestopalov Journal: Curr Eye Res Date: 2013-10-21 Impact factor: 2.424
Authors: Anthony P Wells; David F Garway-Heath; Ali Poostchi; Tracey Wong; Kenneth C Y Chan; Nisha Sachdev Journal: Invest Ophthalmol Vis Sci Date: 2008-03-03 Impact factor: 4.799