Nicola Veronese1, Stefania Maggi2, Caterina Trevisan1, Marianna Noale2, Marina De Rui1, Francesco Bolzetta1, Sabina Zambon2,3, Estella Musacchio3, Leonardo Sartori3, Egle Perissinotto4, Brendon Stubbs5,6, Gaetano Crepaldi2, Enzo Manzato1,2, Giuseppe Sergi1. 1. Department of Medicine (DIMED), Geriatrics Division, University of Padova, Italy. 2. National Research Council, Neuroscience Institute, Aging Branch, Padova, Italy. 3. Department of Medicine (DIMED), Clinica Medica I, University of Padova, Italy. 4. Department of Cardiac, Thoracic and Vascular Sciences, Biostatistics, Epidemiology and Public Health Unit, University of Padova, Padova, Italy. 5. Physiotherapy Department, South London and Maudsley NHS Foundation Trust, London, United Kingdom. 6. Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Abstract
Objective: While osteoarthritis (OA)-related pain increases the risk of physical inactivity, disability, and falls, less is known about whether pain increases the risk of frailty. We investigated if people with OA reporting pain are more likely to develop frailty than people with OA without pain. Design: Population-based prospective cohort study with a follow-up of 4.4 years. Setting: Community. Subjects: The subjects were 1,775 older men and women with osteoarthritis, enrolled in the Progetto Veneto Anziani. Methods: Pain was ascertained according to medical records, symptoms/signs, and use of analgesics. Participants were considered frail if they met three out of five criteria of Fried's Index. Results: Cross-sectional analysis at baseline demonstrated that after adjusting for potential confounders (age, gender, anthropometric and demographic data, comorbidities), people with OA and pain (n = 568) were significantly more likely to have frailty compared with those with OA without pain (n = 1,207; hand OA, OR = 1.86, 95% CI = 1.65-2.09; hip OA, OR = 1.62, 95% CI = 1.44-1.83; knee OA, OR = 1.42, 95% CI = 1.26-1.60; all p < 0.0001). Prospective analysis of 1,152 nonfrail subjects at baseline demonstrated that 19.9% developed incident frailty. A fully-adjusted logistic regression analysis demonstrated that lower limb OA-related pain was associated with an increased risk of developing frailty compared with people with OA and no pain. Conclusions: Pain related to OA might be an important factor influencing the relationship between OA and the development of frailty.
Objective: While osteoarthritis (OA)-related pain increases the risk of physical inactivity, disability, and falls, less is known about whether pain increases the risk of frailty. We investigated if people with OA reporting pain are more likely to develop frailty than people with OA without pain. Design: Population-based prospective cohort study with a follow-up of 4.4 years. Setting: Community. Subjects: The subjects were 1,775 older men and women with osteoarthritis, enrolled in the Progetto Veneto Anziani. Methods:Pain was ascertained according to medical records, symptoms/signs, and use of analgesics. Participants were considered frail if they met three out of five criteria of Fried's Index. Results: Cross-sectional analysis at baseline demonstrated that after adjusting for potential confounders (age, gender, anthropometric and demographic data, comorbidities), people with OA and pain (n = 568) were significantly more likely to have frailty compared with those with OA without pain (n = 1,207; hand OA, OR = 1.86, 95% CI = 1.65-2.09; hip OA, OR = 1.62, 95% CI = 1.44-1.83; knee OA, OR = 1.42, 95% CI = 1.26-1.60; all p < 0.0001). Prospective analysis of 1,152 nonfrail subjects at baseline demonstrated that 19.9% developed incident frailty. A fully-adjusted logistic regression analysis demonstrated that lower limb OA-related pain was associated with an increased risk of developing frailty compared with people with OA and no pain. Conclusions: Pain related to OA might be an important factor influencing the relationship between OA and the development of frailty.
Authors: Giulia Ogliari; Jesper Ryg; Karen Andersen-Ranberg; Lasse Lybecker Scheel-Hincke; Jemima T Collins; Alison Cowley; Claudio Di Lorito; Louise Howe; Katie R Robinson; Vicky Booth; David A Walsh; John R F Gladman; Rowan H Harwood; Tahir Masud Journal: Eur Geriatr Med Date: 2022-10-13 Impact factor: 3.269
Authors: Gregory Livshits; Mary Ni Lochlainn; Ida Malkin; Ruth Bowyer; Serena Verdi; Claire J Steves; Frances M K Williams Journal: Age Ageing Date: 2018-01-01 Impact factor: 10.668