Giulia Ogliari1,2, Jesper Ryg3,4, Karen Andersen-Ranberg3,4,5, Lasse Lybecker Scheel-Hincke5, Jemima T Collins2,6,7, Alison Cowley6,8, Claudio Di Lorito6, Louise Howe6, Katie R Robinson6,8, Vicky Booth6,8, David A Walsh2,9,10, John R F Gladman1,2,6,11, Rowan H Harwood12,13, Tahir Masud1,2,11. 1. Department of Health Care for Older People (HCOP), Queen's Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, Nottinghamshire, UK. 2. NIHR Nottingham Biomedical Research Centre, Nottingham, UK. 3. Department of Geriatric Medicine, Odense University Hospital, Odense, Denmark. 4. Geriatric Research Unit, Department of Clinical Research, University of Southern Denmark, Odense, Denmark. 5. Unit for Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, 5000, Odense, Denmark. 6. Centre for Rehabilitation and Ageing Research, Academic Unit of Injury, Inflammation and Recovery Sciences, School of Medicine, University of Nottingham, Nottingham, UK. 7. University Hospitals of Derby and Burton NHS Foundation Trust, Derby, UK. 8. Research and Innovation, Nottingham University Hospitals NHS Trust, Nottingham, UK. 9. Pain Centre Versus Arthritis, University of Nottingham, Nottingham, UK. 10. Sherwood Forest Hospitals NHS Foundation Trust, Sutton-in-Ashfield, UK. 11. NIHR Applied Research Collaboration-East Midlands, Nottingham, UK. 12. Department of Health Care for Older People (HCOP), Queen's Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, Nottinghamshire, UK. Rowan.Harwood@nottingham.ac.uk. 13. School of Health Sciences, University of Nottingham, Nottingham, UK. Rowan.Harwood@nottingham.ac.uk.
Abstract
PURPOSE: To investigate the longitudinal associations between pain and falls risks in adults. METHODS: Prospective cohort study on data from 40,636 community-dwelling adults ≥ 50 years assessed in Wave 5 and 6 in the Survey of Health, Ageing and Retirement in Europe (SHARE). Socio-demographic and clinical information was collected at baseline (Wave 5). At 2-year follow-up (Wave 6), falls in the previous 6 months were recorded. The longitudinal associations between pain intensity, number of pain sites and pain in specific anatomic sites, respectively, and falls risk were analysed by binary logistic regression models; odds ratios (95% confidence intervals) were calculated. All analyses were adjusted for socio-demographic and clinical factors and stratified by sex. RESULTS: Mean age was 65.8 years (standard deviation 9.3; range 50-103); 22,486 (55.3%) participants were women. At follow-up, 2805 (6.9%) participants reported fall(s) in the previous 6 months. After adjustment, participants with moderate and severe pain at baseline had an increased falls risk at follow-up of 1.35 (1.21-1.51) and 1.52 (1.31-1.75), respectively, compared to those without pain (both p < 0.001); mild pain was not associated with falls risk. Associations between pain intensity and falls risk were greater at younger age (p for interaction < 0.001). Among participants with pain, pain in ≥ 2 sites or all over (multisite pain) was associated with an increased falls risk of 1.29 (1.14-1.45) compared to pain in one site (p < 0.001). CONCLUSIONS: Moderate, severe and multisite pain were associated with an increased risk of subsequent falls in adults.
PURPOSE: To investigate the longitudinal associations between pain and falls risks in adults. METHODS: Prospective cohort study on data from 40,636 community-dwelling adults ≥ 50 years assessed in Wave 5 and 6 in the Survey of Health, Ageing and Retirement in Europe (SHARE). Socio-demographic and clinical information was collected at baseline (Wave 5). At 2-year follow-up (Wave 6), falls in the previous 6 months were recorded. The longitudinal associations between pain intensity, number of pain sites and pain in specific anatomic sites, respectively, and falls risk were analysed by binary logistic regression models; odds ratios (95% confidence intervals) were calculated. All analyses were adjusted for socio-demographic and clinical factors and stratified by sex. RESULTS: Mean age was 65.8 years (standard deviation 9.3; range 50-103); 22,486 (55.3%) participants were women. At follow-up, 2805 (6.9%) participants reported fall(s) in the previous 6 months. After adjustment, participants with moderate and severe pain at baseline had an increased falls risk at follow-up of 1.35 (1.21-1.51) and 1.52 (1.31-1.75), respectively, compared to those without pain (both p < 0.001); mild pain was not associated with falls risk. Associations between pain intensity and falls risk were greater at younger age (p for interaction < 0.001). Among participants with pain, pain in ≥ 2 sites or all over (multisite pain) was associated with an increased falls risk of 1.29 (1.14-1.45) compared to pain in one site (p < 0.001). CONCLUSIONS: Moderate, severe and multisite pain were associated with an increased risk of subsequent falls in adults.
Authors: G A Handrigan; N Maltais; M Gagné; P Lamontagne; D Hamel; N Teasdale; O Hue; P Corbeil; J P Brown; S Jean Journal: Osteoporos Int Date: 2016-08-25 Impact factor: 4.507
Authors: Aron S Buchman; Robert S Wilson; Patricia A Boyle; Yuxiao Tang; Debra A Fleischman; David A Bennett Journal: J Am Geriatr Soc Date: 2007-08-14 Impact factor: 5.562
Authors: Jennifer L Kelsey; Sarah D Berry; Elizabeth Procter-Gray; Lien Quach; Uyen-Sa D T Nguyen; Wenjun Li; Douglas P Kiel; Lewis A Lipsitz; Marian T Hannan Journal: J Am Geriatr Soc Date: 2010-09-09 Impact factor: 5.562