| Literature DB >> 24113520 |
Hardeep S Oberoi1, Natalia V Nukolova, Alexander V Kabanov, Tatiana K Bronich.
Abstract
Platinum based anticancer drugs have revolutionized cancer chemotherapy, and continue to be in widespread clinical use especially for management of tumors of the ovary, testes, and the head and neck. However, several dose limiting toxicities associated with platinum drug use, partial anti-tumor response in most patients, development of drug resistance, tumor relapse, and many other challenges have severely limited the patient quality of life. These limitations have motivated an extensive research effort towards development of new strategies for improving platinum therapy. Nanocarrier-based delivery of platinum compounds is one such area of intense research effort beginning to provide encouraging preclinical and clinical results and may allow the development of the next generation of platinum chemotherapy. This review highlights current understanding on the pharmacology and limitations of platinum compounds in clinical use, and provides a comprehensive analysis of various platinum-polymer complexes, micelles, dendrimers, liposomes and other nanoparticles currently under investigation for delivery of platinum drugs.Entities:
Keywords: 5-FU; 5-fluorouracil; BIC; Block ionomer complex; CDDP; CMC; CTR1; DACHPt; DMPG; DPPG; Dendrime; Drug delivery systems; HPGs; HPMA; Liposome; MWCNTs; Micelle; N-(2-hydroxypropyl)methacrylamide; NDDP; NSCLC; Nanoparticle; Nanotube; OCTs; PAMAM; PAsp; PEG; PEG-b-(polymethacrylic acid); PEG-b-PCL; PEG-b-PMAA; PEG-b-polycaprolactone; PGlu; PIC; Platinum drugs; Polymer conjugate; RES; SCLC; SPC-3; SWCNTs; block ionomer complexes; cis-bis-neodecanoato-trans-R,R-1,2-diaminocyclohexane platinum (II); cis-dichloro(1,2-diamminocyclohexane) platinum (II); cisplatin; copper transporter 1; critical micelle concentration; dimyristoyl phosphatidylglycerol; dipalmitoyl phosphatidylglycerol; hyperbranched polyglycerols; multi-walled carbon nanotubes; non-small cell lung cancer; organic cation transporters; poly(aspartic acid); poly(glutamic acid); polyamidoamines; polyethylene glycol; polyion complex; reticuloendothelial system; single-walled carbon nanotubes; small cell lung cancer; soy phosphatidylcholine
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Year: 2013 PMID： 24113520 PMCID： PMC4197009 DOI： 10.1016/j.addr.2013.09.014
Source DB: PubMed Journal: Adv Drug Deliv Rev ISSN： 0169-409X Impact factor: 15.470