Jeong Won Lee1, Ju Ock Na2, Du-Young Kang3, Seock Yeol Lee4, Sang Mi Lee5. 1. Department of Nuclear Medicine, Catholic Kwandong University College of Medicine, International St Mary's Hospital, Incheon, Korea; Institute of Integrative Medicine, Catholic Kwandong University College of Medicine, International St Mary's Hospital, Incheon, Korea. 2. Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, Korea. 3. Department of Thoracic and Cardiovascular Surgery, Catholic Kwandong University College of Medicine, International St Mary's Hospital, Incheon, Korea. 4. Department of Thoracic and Cardiovascular Surgery, Soonchunhyang University Cheonan Hospital, Cheonan, Korea. 5. Department of Nuclear Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, Korea. Electronic address: gareen@naver.com.
Abstract
BACKGROUND: This study evaluated the relationship between 18F-fluorodeoxyglucose (FDG) uptake in bone marrow (BM) on positron emission tomography (PET)/computed tomography (CT) imaging and serum inflammatory markers and assessed the prognostic value of FDG uptake of BM in patients with non-small-cell lung cancer (NSCLC) who underwent curative surgical resection. PATIENTS AND METHODS: We retrospectively enrolled 110 NSCLC patients who underwent FDG PET/CT imaging and subsequent curative surgical resection. The maximum standardized uptake value of NSCLC (Tmax), mean FDG uptake of BM (BM SUV), and BM to liver uptake ratio (BLR) were measured. The relationships between BM SUV, BLR, and serum inflammatory markers were evaluated and the prognostic significance of PET/CT parameters for predicting recurrence-free survival (RFS) and overall survival (OS) were assessed. RESULTS: BM SUV and BLR were significantly associated with serum C-reactive protein (CRP) level, white blood cell count, and the neutrophil to lymphocyte ratio (NLR). BLR was also significantly correlated with serum albumin and the platelet to lymphocyte ratio. In univariate analysis, tumor, node, metastases (TNM) stage, serum CRP level, NLR, Tmax, and BLR were significant prognostic factors for RFS and OS, whereas histopathology and tumor size were significant prognostic factors for RFS. In multivariate analysis, BLR, histopathology, TNM stage, and Tmax were independent prognostic factors for RFS and TNM stage and Tmax were independent prognostic factors for OS. CONCLUSION: FDG uptake of BM on PET/CT imaging was correlated with serum inflammatory markers and was an independent predictor for RFS, along with FDG uptake of NSCLC.
BACKGROUND: This study evaluated the relationship between 18F-fluorodeoxyglucose (FDG) uptake in bone marrow (BM) on positron emission tomography (PET)/computed tomography (CT) imaging and serum inflammatory markers and assessed the prognostic value of FDG uptake of BM in patients with non-small-cell lung cancer (NSCLC) who underwent curative surgical resection. PATIENTS AND METHODS: We retrospectively enrolled 110 NSCLCpatients who underwent FDG PET/CT imaging and subsequent curative surgical resection. The maximum standardized uptake value of NSCLC (Tmax), mean FDG uptake of BM (BM SUV), and BM to liver uptake ratio (BLR) were measured. The relationships between BM SUV, BLR, and serum inflammatory markers were evaluated and the prognostic significance of PET/CT parameters for predicting recurrence-free survival (RFS) and overall survival (OS) were assessed. RESULTS: BM SUV and BLR were significantly associated with serum C-reactive protein (CRP) level, white blood cell count, and the neutrophil to lymphocyte ratio (NLR). BLR was also significantly correlated with serum albumin and the platelet to lymphocyte ratio. In univariate analysis, tumor, node, metastases (TNM) stage, serum CRP level, NLR, Tmax, and BLR were significant prognostic factors for RFS and OS, whereas histopathology and tumor size were significant prognostic factors for RFS. In multivariate analysis, BLR, histopathology, TNM stage, and Tmax were independent prognostic factors for RFS and TNM stage and Tmax were independent prognostic factors for OS. CONCLUSION:FDG uptake of BM on PET/CT imaging was correlated with serum inflammatory markers and was an independent predictor for RFS, along with FDG uptake of NSCLC.
Authors: Jeong Won Lee; Moon-Soo Lee; Il Kwon Chung; Myoung Won Son; Young Sin Cho; Sang Mi Lee Journal: World J Gastroenterol Date: 2017-04-07 Impact factor: 5.742
Authors: Jeong Won Lee; Sung Yong Kim; Sun Wook Han; Jong Eun Lee; Hyun Ju Lee; Nam Hun Heo; Sang Mi Lee Journal: EJNMMI Res Date: 2020-06-30 Impact factor: 3.138
Authors: Sarah A Mattonen; Guido A Davidzon; Jalen Benson; Ann N C Leung; Minal Vasanawala; George Horng; Joseph B Shrager; Sandy Napel; Viswam S Nair Journal: Radiology Date: 2019-09-17 Impact factor: 29.146