Mario J Hitschfeld1, Terry D Schneekloth2, Cassie C Kennedy3, Teresa A Rummans4, Shehzad K Niazi5, Adriana R Vasquez5, Jennifer R Geske6, Tanya M Petterson7, Walter K Kremers8, Sheila G Jowsey-Gregoire9. 1. Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN; Psychiatry and Mental Health Service, Sotero Del Rio Hospital, Puente Alto, Santiago, Chile. 2. Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN; William J. von Liebig Transplant Center, Mayo Clinic, Rochester, MN. Electronic address: schneekloth.terry@mayo.edu. 3. Psychiatry and Mental Health Service, Sotero Del Rio Hospital, Puente Alto, Santiago, Chile; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN; Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN. 4. Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN; Department of Psychiatry and Psychology, Mayo Clinic, Jacksonville, FL. 5. Department of Psychiatry and Psychology, Mayo Clinic, Jacksonville, FL. 6. Department of Health Sciences Research, Mayo Clinic, Rochester, MN. 7. Psychiatry and Mental Health Service, Sotero Del Rio Hospital, Puente Alto, Santiago, Chile; Department of Health Sciences Research, Mayo Clinic, Rochester, MN. 8. Psychiatry and Mental Health Service, Sotero Del Rio Hospital, Puente Alto, Santiago, Chile; Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN. 9. Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN; William J. von Liebig Transplant Center, Mayo Clinic, Rochester, MN.
Abstract
BACKGROUND: The United Network for Organ Sharing mandates a psychosocial assessment of transplant candidates before listing. A quantified measure for determining transplant candidacy is the Psychosocial Assessment of Candidates for Transplant (PACT) scale. This instrument's predictive value for survival has not been rigorously evaluated among lung transplantation recipients. METHODS: We reviewed medical records of all patients who underwent lung transplantation at Mayo Clinic, Rochester from 2000-2012. A transplant psychiatrist had assessed lung transplant candidates for psychosocial risk with the PACT scale. Recipients were divided into high- and low psychosocial risk cohorts using a PACT score cutoff of 2. The main outcome variable was posttransplant survival. Mortality was analyzed using the Kaplan-Meier estimator and Cox proportional hazard models. RESULTS: This study included 110 lung recipients: 57 (51.8%) were females, 101 (91.8%) Whites, mean age: 56.4 years. Further, 7 (6.4%) recipients received an initial PACT score <2 (poor or borderline candidates) and later achieved a higher score, allowing transplant listing; 103 (93.6%) received initial scores ≥2 (acceptable, good or great candidates). An initial PACT score < 2 was modestly associated with higher mortality (adjusted hazard ratio = 2.73, p = 0.04). CONCLUSIONS: Lung transplant recipients who initially received a low score on the PACT scale, reflecting poor or borderline psychosocial candidacy, experienced greater likelihood of mortality. This primary finding suggests that the psychosocial assessment, as measured by the PACT scale, may provide additional mortality risk stratification for lung transplant candidates.
BACKGROUND: The United Network for Organ Sharing mandates a psychosocial assessment of transplant candidates before listing. A quantified measure for determining transplant candidacy is the Psychosocial Assessment of Candidates for Transplant (PACT) scale. This instrument's predictive value for survival has not been rigorously evaluated among lung transplantation recipients. METHODS: We reviewed medical records of all patients who underwent lung transplantation at Mayo Clinic, Rochester from 2000-2012. A transplant psychiatrist had assessed lung transplant candidates for psychosocial risk with the PACT scale. Recipients were divided into high- and low psychosocial risk cohorts using a PACT score cutoff of 2. The main outcome variable was posttransplant survival. Mortality was analyzed using the Kaplan-Meier estimator and Cox proportional hazard models. RESULTS: This study included 110 lung recipients: 57 (51.8%) were females, 101 (91.8%) Whites, mean age: 56.4 years. Further, 7 (6.4%) recipients received an initial PACT score <2 (poor or borderline candidates) and later achieved a higher score, allowing transplant listing; 103 (93.6%) received initial scores ≥2 (acceptable, good or great candidates). An initial PACT score < 2 was modestly associated with higher mortality (adjusted hazard ratio = 2.73, p = 0.04). CONCLUSIONS: Lung transplant recipients who initially received a low score on the PACT scale, reflecting poor or borderline psychosocial candidacy, experienced greater likelihood of mortality. This primary finding suggests that the psychosocial assessment, as measured by the PACT scale, may provide additional mortality risk stratification for lung transplant candidates.
Authors: Yvonne Tran Bui; Matthew A Hathcock; Roberto P Benzo; Marie M Budev; Satish Chandrashekaran; David B Erasmus; Erika D Lease; Deborah J Levine; Karin L Thompson; Bradley K Johnson; Sheila G Jowsey-Gregoire; Cassie C Kennedy Journal: Clin Transplant Date: 2020-09-23 Impact factor: 2.863
Authors: Kelly M Pennington; Roberto P Benzo; Terry D Schneekloth; Marie Budev; Satish Chandrashekaran; David B Erasmus; Erika D Lease; Deborah J Levine; Karin Thompson; Elizabeth Stevens; Paul J Novotny; Cassie C Kennedy Journal: Prog Transplant Date: 2019-12-16 Impact factor: 1.187
Authors: Ersilia M DeFilippis; Khadijah Breathett; Elena M Donald; Shunichi Nakagawa; Koji Takeda; Hiroo Takayama; Lauren K Truby; Gabriel Sayer; Paolo C Colombo; Melana Yuzefpolskaya; Nir Uriel; Maryjane A Farr; Veli K Topkara Journal: Circ Heart Fail Date: 2020-09-08 Impact factor: 8.790