Yvonne Tran Bui1, Matthew A Hathcock2, Roberto P Benzo3, Marie M Budev4, Satish Chandrashekaran5, David B Erasmus6, Erika D Lease7, Deborah J Levine8, Karin L Thompson9, Bradley K Johnson2, Sheila G Jowsey-Gregoire10, Cassie C Kennedy3,11. 1. Mayo Clinic Alix School of Medicine, Rochester, Minnesota, USA. 2. Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, USA. 3. Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota, USA. 4. Division of Pulmonary and Critical Care Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA. 5. Division of Pulmonary, Critical Care & Sleep Medicine, University of Florida, Gainesville, Florida, USA. 6. Transplant Medicine, Mayo Clinic, Jacksonville, Florida, USA. 7. Division of Pulmonary, Critical Care, and Sleep Medicine, University of Washington, Seattle, Washington, USA. 8. Division of Pulmonary and Critical Care Medicine, University of Texas Health, San Antonio, Texas, USA. 9. Pulmonary Clinical Research Unit, Mayo Clinic, Rochester, Minnesota, USA. 10. Department of Psychiatry & Psychology, Mayo Clinic, Rochester, Minnesota, USA. 11. William J. von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, Minnesota, USA.
Abstract
BACKGROUND: Resilience represents the capacity to adapt to adversity. Resilience can improve following behavioral interventions. We examined lung transplant candidates' resilience as a novel predictor using the Connor-Davidson Resilience Scale (RISC-10). METHODS: Waitlisted candidates at six centers were mailed questionnaires from 9/16/2015 to 10/1/2019. Follow-up surveys were collected annually and post-transplant. Outcomes were recorded through February 17, 2020. Primary outcome was pre-transplant death/delisting. Analyses included t test or chi-square for group comparisons, Pearson's correlation coefficients for strength of relationships, and Cox proportional-hazard models to evaluate associations with outcomes, adjusting for age, sex, and mood. RESULTS: Participation was 55.3% (N = 199). Baseline RISC-10 averaged 32.0 ± 5.6 and did not differ by demographics, primary transplant diagnosis, or disease severity markers. RISC-10 did not correlate to the commonly utilized Psychosocial Assessment of Candidates for Transplant [PACT] or Stanford Integrated Psychosocial Assessment for Transplantation [SIPAT] tools. Scores < 26.3 (representing > 1 standard deviation below population average) occurred in 16% and were associated with pre-transplant death or delisting, adjusted Hazard Ratio of 2.60 (95% Confidence Interval 1.23-5.77; P = .01). CONCLUSION: One in six lung candidates had low resilience, predicting increased pre-transplant death/delisting. RISC-10 did not correlate with PACT or SIPAT; resilience may represent a novel risk factor.
BACKGROUND: Resilience represents the capacity to adapt to adversity. Resilience can improve following behavioral interventions. We examined lung transplant candidates' resilience as a novel predictor using the Connor-Davidson Resilience Scale (RISC-10). METHODS: Waitlisted candidates at six centers were mailed questionnaires from 9/16/2015 to 10/1/2019. Follow-up surveys were collected annually and post-transplant. Outcomes were recorded through February 17, 2020. Primary outcome was pre-transplant death/delisting. Analyses included t test or chi-square for group comparisons, Pearson's correlation coefficients for strength of relationships, and Cox proportional-hazard models to evaluate associations with outcomes, adjusting for age, sex, and mood. RESULTS: Participation was 55.3% (N = 199). Baseline RISC-10 averaged 32.0 ± 5.6 and did not differ by demographics, primary transplant diagnosis, or disease severity markers. RISC-10 did not correlate to the commonly utilized Psychosocial Assessment of Candidates for Transplant [PACT] or Stanford Integrated Psychosocial Assessment for Transplantation [SIPAT] tools. Scores < 26.3 (representing > 1 standard deviation below population average) occurred in 16% and were associated with pre-transplant death or delisting, adjusted Hazard Ratio of 2.60 (95% Confidence Interval 1.23-5.77; P = .01). CONCLUSION: One in six lung candidates had low resilience, predicting increased pre-transplant death/delisting. RISC-10 did not correlate with PACT or SIPAT; resilience may represent a novel risk factor.
Authors: Bruce Arroll; Felicity Goodyear-Smith; Susan Crengle; Jane Gunn; Ngaire Kerse; Tana Fishman; Karen Falloon; Simon Hatcher Journal: Ann Fam Med Date: 2010 Jul-Aug Impact factor: 5.166
Authors: David G Cohen; Jason D Christie; Brian J Anderson; Joshua M Diamond; Ryan P Judy; Rupal J Shah; Edward Cantu; Scarlett L Bellamy; Nancy P Blumenthal; Ejigayehu Demissie; Ramona O Hopkins; Mark E Mikkelsen Journal: Ann Am Thorac Soc Date: 2014-05
Authors: Domagoj A Vodanovich; Thomas J Bicknell; Anne E Holland; Catherine J Hill; Nola Cecins; Sue Jenkins; Christine F McDonald; Angela T Burge; Philip Thompson; Robert G Stirling; Annemarie L Lee Journal: Respiration Date: 2015-06-18 Impact factor: 3.580