Literature DB >> 29731393

NRF2 and the Hallmarks of Cancer.

Montserrat Rojo de la Vega1, Eli Chapman1, Donna D Zhang2.   

Abstract

The transcription factor NRF2 is the master regulator of the cellular antioxidant response. Though recognized originally as a target of chemopreventive compounds that help prevent cancer and other maladies, accumulating evidence has established the NRF2 pathway as a driver of cancer progression, metastasis, and resistance to therapy. Recent studies have identified new functions for NRF2 in the regulation of metabolism and other essential cellular functions, establishing NRF2 as a truly pleiotropic transcription factor. In this review, we explore the roles of NRF2 in the hallmarks of cancer, indicating both tumor suppressive and tumor-promoting effects.
Copyright © 2018 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  KEAP1; NRF2; antioxidant response element (ARE); cancer initiation and progression; carcinogenesis; chemoresistance; metabolic reprogramming; metastasis; oxidative stress

Mesh：

Substances：

Year:  2018        PMID： 29731393      PMCID： PMC6039250          DOI： 10.1016/j.ccell.2018.03.022

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  339 in total

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  323 in total

1.  Heme oxygenase promotes B-Raf-dependent melanosphere formation.

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4.  Nrf1-mediated transcriptional regulation of the proteasome requires a functional TIP60 complex.

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Journal:  J Biol Chem       Date:  2018-12-17       Impact factor: 5.157

Review 5.  Mitochondrial Involvement in Migration, Invasion and Metastasis.

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6.  Glucose-6-Phosphate Dehydrogenase Is Not Essential for K-Ras-Driven Tumor Growth or Metastasis.

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Review 8.  Oxidative Stress in Cancer.

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