AIM: To analyse and predict early response 3 months post definitive chemoradiation (CCRT) utilising tumour volume (TV) measurement in locally advanced head and neck cancers (LAHNC). BACKGROUND: LAHNC are 3-dimentional lesions. The largest diameter of these tumours measured for T-classification may not necessarily reflect the true tumour dimensions. TV accurately reflects the tumour burden because it is a measurement of tumour burden in all three dimensions. MATERIALS AND METHODS: It is a single institutional prospective study including 101 patients with LAHNC treated with definitive CCRT. TV data noted were primary tumour volume (PTV), total nodal volume (TNV) and total tumour volume (TTV). Response evaluation was done at 3 months after the completion of definitive CCRT and patients were categorised either having achieved complete response (CR) or residual disease. RESULTS: Patients who had not achieved CR were found to have larger TV compared with those who had achieved CR. There were significant inverse correlations between PTV and response (median 16.37 cm(3) vs. 45.2 cm(3); p = 0.001), and between TTV and response (median 36.14 cm(3) vs. 66.06 cm(3); p < 0.001). Receiver operating characteristic (ROC) analysis identified an "optimal cut-off" value of 41 cm(3) for PTV and 42 cm(3) for TTV above and below which the magnitude of difference in response was the greatest. CONCLUSIONS: If response evaluation 3 months post CCRT is to be predicted it is simply not enough to measure the largest single dimension of the tumour. TV seems to be a better and more accurate reflection of the true total tumour burden or extent of the disease.
AIM: To analyse and predict early response 3 months post definitive chemoradiation (CCRT) utilising tumour volume (TV) measurement in locally advanced head and neck cancers (LAHNC). BACKGROUND: LAHNC are 3-dimentional lesions. The largest diameter of these tumours measured for T-classification may not necessarily reflect the true tumour dimensions. TV accurately reflects the tumour burden because it is a measurement of tumour burden in all three dimensions. MATERIALS AND METHODS: It is a single institutional prospective study including 101 patients with LAHNC treated with definitive CCRT. TV data noted were primary tumour volume (PTV), total nodal volume (TNV) and total tumour volume (TTV). Response evaluation was done at 3 months after the completion of definitive CCRT and patients were categorised either having achieved complete response (CR) or residual disease. RESULTS:Patients who had not achieved CR were found to have larger TV compared with those who had achieved CR. There were significant inverse correlations between PTV and response (median 16.37 cm(3) vs. 45.2 cm(3); p = 0.001), and between TTV and response (median 36.14 cm(3) vs. 66.06 cm(3); p < 0.001). Receiver operating characteristic (ROC) analysis identified an "optimal cut-off" value of 41 cm(3) for PTV and 42 cm(3) for TTV above and below which the magnitude of difference in response was the greatest. CONCLUSIONS: If response evaluation 3 months post CCRT is to be predicted it is simply not enough to measure the largest single dimension of the tumour. TV seems to be a better and more accurate reflection of the true total tumour burden or extent of the disease.
Entities:
Keywords:
Chemoradiation; Early response; Head neck; Prognostic factors; Tumour volume
Authors: Joost L Knegjens; Michael Hauptmann; Frank A Pameijer; Alfons J Balm; Frank J Hoebers; Josien A de Bois; Johannes H Kaanders; Carla M van Herpen; Cornelia G Verhoef; Oda B Wijers; Ruud G Wiggenraad; Jan Buter; Coen R Rasch Journal: Head Neck Date: 2011-03 Impact factor: 3.147
Authors: Vincent F H Chong; Jia-Yin Zhou; James B K Khoo; Kap-Luk Chan; Jing Huang Journal: Int J Radiat Oncol Biol Phys Date: 2005-11-03 Impact factor: 7.038
Authors: Sandro V Porceddu; Elizabeth Jarmolowski; Rodney J Hicks; Rob Ware; LeAnn Weih; Danny Rischin; June Corry; Lester J Peters Journal: Head Neck Date: 2005-03 Impact factor: 3.147
Authors: Jürgen Dunst; Peter Stadler; Axel Becker; Christine Lautenschläger; Tanja Pelz; Gabriele Hänsgen; Michael Molls; Thomas Kuhnt Journal: Strahlenther Onkol Date: 2003-08 Impact factor: 3.621
Authors: Jaime Gómez-Millán; Maria Dolores Toledo; Yolanda Lupiañez; Antonio Rueda; Jose Manuel Trigo; Antonio Sachetti; Jose Antonio Medina Journal: Clin Transl Oncol Date: 2012-08-22 Impact factor: 3.405
Authors: W R Lee; A A Mancuso; E M Saleh; W M Mendenhall; J T Parsons; R R Million Journal: Int J Radiat Oncol Biol Phys Date: 1993-03-15 Impact factor: 7.038
Authors: George A Plataniotis; Maria-Ekaterini Theofanopoulou; Anna Kalogera-Fountzila; Afroditi Haritanti; Elisabeta Ciuleanou; Nicolae Ghilezan; Nikolaos Zamboglou; Athanasios Dimitriadis; Ioannis Sofroniadis; George Fountzilas Journal: Int J Radiat Oncol Biol Phys Date: 2004-07-15 Impact factor: 7.038
Authors: Kacper Guglas; Marta Bogaczyńska; Tomasz Kolenda; Marcel Ryś; Anna Teresiak; Renata Bliźniak; Izabela Łasińska; Jacek Mackiewicz; Katarzyna Lamperska Journal: Contemp Oncol (Pozn) Date: 2017-12-30