BACKGROUND: Tumor volume is an important predictor of outcome in radiotherapy alone. Its significance in concomitant chemoradiation (CCRT) is much less clear. We analyzed the prognostic value of primary tumor volume for advanced head and neck squamous cell carcinoma (HNSCC) treated with CCRT. METHODS: Three hundred sixty patients treated with definitive CCRT for advanced HNSCC were selected. The pretreatment MRI or CT scan was used to calculate the primary tumor volume. Median follow-up was 19.8 months. RESULTS: The average primary tumor volume was 37.0 cm³ (range, 2.1-182.7 cm³; median, 28.7 cm³). Multivariate analysis showed a significant effect of tumor volume on local control. The hazard ratio for a local recurrence increased by 14% per 10 cm³ volume increase (95% CI, 8% to 21%). There was no significant independent effect of T and N status on local control. CONCLUSION: For advanced HNSCC, tumor volume is more powerful for predicting outcome after CCRT than TNM status.
BACKGROUND:Tumor volume is an important predictor of outcome in radiotherapy alone. Its significance in concomitant chemoradiation (CCRT) is much less clear. We analyzed the prognostic value of primary tumor volume for advanced head and neck squamous cell carcinoma (HNSCC) treated with CCRT. METHODS: Three hundred sixty patients treated with definitive CCRT for advanced HNSCC were selected. The pretreatment MRI or CT scan was used to calculate the primary tumor volume. Median follow-up was 19.8 months. RESULTS: The average primary tumor volume was 37.0 cm³ (range, 2.1-182.7 cm³; median, 28.7 cm³). Multivariate analysis showed a significant effect of tumor volume on local control. The hazard ratio for a local recurrence increased by 14% per 10 cm³ volume increase (95% CI, 8% to 21%). There was no significant independent effect of T and N status on local control. CONCLUSION: For advanced HNSCC, tumor volume is more powerful for predicting outcome after CCRT than TNM status.
Authors: Mona Kamal; Sweet Ping Ng; Salman A Eraj; Crosby D Rock; Brian Pham; Jay A Messer; Adam S Garden; William H Morrison; Jack Phan; Steven J Frank; Adel K El-Naggar; Jason M Johnson; Lawrence E Ginsberg; Renata Ferrarotto; Jan S Lewin; Katherine A Hutcheson; Carlos E Cardenas; Mark E Zafereo; Stephen Y Lai; Amy C Hessel; Randal S Weber; G Brandon Gunn; Clifton D Fuller; Abdallah S R Mohamed; David I Rosenthal Journal: Oral Oncol Date: 2018-02-10 Impact factor: 5.337
Authors: Kara S Davis; Chwee Ming Lim; David A Clump; Dwight E Heron; James P Ohr; Seungwon Kim; Umamaheswar Duvvuri; Jonas T Johnson; Robert L Ferris Journal: Head Neck Date: 2015-12-17 Impact factor: 3.147
Authors: Jay C Shiao; Abdallah S R Mohamed; Jay A Messer; Katherine A Hutcheson; Jason M Johnson; Heiko Enderling; Mona Kamal; Benjamin W Warren; Brian Pham; William H Morrison; Mark E Zafereo; Amy C Hessel; Stephen Y Lai; Merril S Kies; Renata Ferrarotto; Adam S Garden; Donald F Schomer; G Brandon Gunn; Jack Phan; Steven J Frank; Beth M Beadle; Randal S Weber; Jan S Lewin; David I Rosenthal; Clifton D Fuller Journal: Head Neck Date: 2017-05-02 Impact factor: 3.147
Authors: Stephanie Flukes; Shivangi Lohia; Christopher A Barker; Jennifer R Cracchiolo; Ian Ganly; Snehal G Patel; Benjamin R Roman; Jatin P Shah; Alexander N Shoushtari; Viviane Tabar; Akash Shah; Marc A Cohen Journal: Head Neck Date: 2020-08-01 Impact factor: 3.147
Authors: T Rutkowski; A Wygoda; K Składowski; B Hejduk; R Rutkowski; Z Kołosza; B Maciejewski Journal: Strahlenther Onkol Date: 2013-08-29 Impact factor: 3.621