Literature DB >> 27484513

The therapeutic journey of pyridazinone.

Wasim Akhtar1, M Shaquiquzzaman1, Mymoona Akhter1, Garima Verma1, Mohemmed Faraz Khan1, M Mumtaz Alam2.   

Abstract

Pyridazinones have drawn a substantial attention within the field of research analysis and development. The moiety is a subject matter of intensive research because of its wide spectrum of biological activities and therapeutic applications. The synthesis of pyridazinone and investigation of their chemical and biological activities have gained additional importance in recent years. In this review, we have compiled and discussed various biological and therapeutic potential of pyridazinone derivatives.
Copyright © 2016 Elsevier Masson SAS. All rights reserved.

Entities:  

Keywords:  Anti-inflammatory and analgesic; Anticancer; Antiviral; Biological activity; Heterocyclic; Pyridazinone

Mesh：

Substances：

Year:  2016        PMID： 27484513     DOI： 10.1016/j.ejmech.2016.07.061

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  12 in total

1.  Crystal structure and Hirshfeld surface analysis of ethyl 2-[5-(3-chloro-benz-yl)-6-oxo-3-phenyl-1,6-di-hydro-pyridazin-1-yl]acetate.

Authors:  Fouad El Kalai; Cemile Baydere; Said Daoui; Rafik Saddik; Necmi Dege; Khalid Karrouchi; Noureddine Benchat
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2019-05-24

2.  A new pyridazinone exhibits potent cytotoxicity on human cancer cells via apoptosis and poly-ubiquitinated protein accumulation.

Authors:  Denisse A Gutierrez; Rebecca E DeJesus; Lisett Contreras; Isela A Rodriguez-Palomares; Paulina J Villanueva; Karol S Balderrama; Lenore Monterroza; Manuel Larragoity; Armando Varela-Ramirez; Renato J Aguilera
Journal:  Cell Biol Toxicol       Date:  2019-03-01       Impact factor: 6.691

3.  Synthesis of Some New Pyridazine Derivatives for Anti-HAV Evaluation.

Authors:  Eman M Flefel; Waled A Tantawy; Walaa I El-Sofany; Mahmoud El-Shahat; Ahmed A El-Sayed; Dina N Abd-Elshafy
Journal:  Molecules       Date:  2017-01-17       Impact factor: 4.411

4.  Crystal structure, Hirshfeld surface analysis and DFT studies of 2-[5-(4-methyl-benz-yl)-6-oxo-3-phenyl-1,6-di-hydro-pyridazin-1-yl]acetic acid.

Authors:  Said Daoui; Cemile Baydere; Fouad El Kalai; Lhassane Mahi; Necmi Dege; Khalid Karrouchi; Noureddine Benchat
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2019-11-26

5.  Crystal structure, Hirshfeld surface analysis and DFT studies of 6-[(E)-2-(thio-phen-2-yl)ethenyl]-4,5-di-hydro-pyridazin-3(2H)-one.

Authors:  Said Daoui; Emine Berrin Çınar; Fouad El Kalai; Rafik Saddik; Necmi Dege; Khalid Karrouchi; Noureddine Benchat
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2019-11-15

6.  Crystal structures and Hirshfeld surface analyses of 4-benzyl-6-phenyl-4,5-di-hydro-pyridazin-3(2H)-one and methyl 2-[5-(2,6-di-chloro-benz-yl)-6-oxo-3-phenyl-1,4,5,6-tetra-hydropyridazin-1-yl]acetate.

Authors:  Said Dadou; Sevgi Kansiz; Said Daoui; Fouad El Kalai; Cemile Baydere; Rafik Saddik; Khalid Karrouchi; Necmi Dege; Noureddine Benchat
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2019-10-22

7.  Crystal structure and Hirshfeld surface analysis of (E)-6-(4-hy-droxy-3-meth-oxy-styr-yl)-4,5-di-hydro-pyridazin-3(2H)-one.

Authors:  Said Daoui; Cemile Baydere; Fouad El Kalai; Rafik Saddik; Necmi Dege; Khalid Karrouchi; Noureddine Benchat
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2019-10-31

8.  A new compound of thiophenylated pyridazinone IMB5043 showing potent antitumor efficacy through ATM-Chk2 pathway.

Authors:  Jianhua Gong; Yanbo Zheng; Ying Wang; Weijin Sheng; Yi Li; Xiujun Liu; Shuyi Si; Rongguang Shao; Yongsu Zhen
Journal:  PLoS One       Date:  2018-02-02       Impact factor: 3.240

9.  Polymorphism of 2-(5-benzyl-6-oxo-3-phenyl-1,6-di-hydro-pyridazin-1-yl)acetic acid with two monoclinic modifications: crystal structures and Hirshfeld surface analyses.

Authors:  Said Daoui; Cemile Baydere; Tarik Chelfi; Fouad El Kalai; Necmi Dege; Khalid Karrouchi; Noureddine Benchat
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2020-02-25

10.  Synthesis, spectroscopy, crystal structure, TGA/DTA study, DFT and molecular docking investigations of (E)-4-(4-methylbenzyl)-6-styrylpyridazin-3(2H)-one.

Authors:  Fouad El Kalai; Emine Berrin Çınar; Chin-Hung Lai; Said Daoui; Tarik Chelfi; Mustapha Allali; Necmi Dege; Khalid Karrouchi; Noureddine Benchat
Journal:  J Mol Struct       Date:  2020-10-10       Impact factor: 3.196
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