S Fichtner1, J Senges2, M Hochadel2, R Tilz3, S Willems4, L Eckardt5, T Deneke6, T Lewalter7, U Dorwarth8, C Reithmann9, J Brachmann10, G Steinbeck11, S Kääb12. 1. Klinikum der LMU München, Medizinische Klinik und Poliklinik I, Deutsches Zentrum für Herz-Kreislauferkrankungen (DZHK), partner site Munich Heart Alliance, Marchioninistr. 15, 81377, Munich, Germany. Stephanie.fichtner@med.uni-muenchen.de. 2. Stiftung Institut für Herzinfarktforschung (IHF), Ludwigshafen, Germany. 3. Universitätsklinikum Schleswig-Holstein, Lübeck, Germany. 4. Universitätsklinik Hamburg-Eppendorf, Hamburg, Germany. 5. Universitätsklinikum Münster, Münster, Germany. 6. Herz- und Gefäßklinik Bad Neustadt, Bad Neustadt, Germany. 7. Peter Osypka Herzzentrum, Internistische Klinik Dr. Müller, Munich, Germany. 8. Klinikum München-Bogenhausen, Munich, Germany. 9. Helios Klinikum München-West, Munich, Germany. 10. Klinikum Coburg, Coburg, Germany. 11. Zentrum für Kardiologie am Klinikum Starnberg, Starnberg, Germany. 12. Klinikum der LMU München, Medizinische Klinik und Poliklinik I, Deutsches Zentrum für Herz-Kreislauferkrankungen (DZHK), partner site Munich Heart Alliance, Marchioninistr. 15, 81377, Munich, Germany.
Abstract
BACKGROUND: Patients with frequent premature ventricular contractions (PVCs) are often highly symptomatic with significantly reduced quality-of-life. We evaluated the outcome and success of PVC ablation in patients in the German Ablation Registry. METHODS: The German Ablation Registry is a nationwide prospective multicenter database of patients who underwent an ablation procedure, initiated by the "Stiftung Institut für Herzinfarktforschung" (IHF), Ludwigshafen, Germany. Data were acquired from March 2007 to May 2011. Patients underwent PVC ablation in the enrolling ablation centers. RESULTS: A total of 408 patients (age 53.5 ± 15 years, 55 % female) undergoing ablation for PVCs were included. 32 % of patients showed a co-existing structural heart disease. Acute ablation success of the procedure was 82 % in the overall patient group. In patients without structural heart disease, acute success was significantly higher compared with patients with structural heart disease (86 vs. 74 %, p = 0.002). All patients were discharged alive after a median of 3 days. No patient suffered an acute myocardial infarction, stroke, or major bleeding. After 12 months' follow-up, 99 % of patients were still alive showing a significant different mortality between patients with structural heart disease compared with those without (2.3 vs. 0 %, p = 0.012). In addition, 76 % of patients showed significantly improved symptoms after 12 months of follow-up. CONCLUSION: Based on the data from this registry, ablation of PVCs is a safe and efficient procedure with an excellent outcome and improved symptoms after 12 months.
BACKGROUND:Patients with frequent premature ventricular contractions (PVCs) are often highly symptomatic with significantly reduced quality-of-life. We evaluated the outcome and success of PVC ablation in patients in the German Ablation Registry. METHODS: The German Ablation Registry is a nationwide prospective multicenter database of patients who underwent an ablation procedure, initiated by the "Stiftung Institut für Herzinfarktforschung" (IHF), Ludwigshafen, Germany. Data were acquired from March 2007 to May 2011. Patients underwent PVC ablation in the enrolling ablation centers. RESULTS: A total of 408 patients (age 53.5 ± 15 years, 55 % female) undergoing ablation for PVCs were included. 32 % of patients showed a co-existing structural heart disease. Acute ablation success of the procedure was 82 % in the overall patient group. In patients without structural heart disease, acute success was significantly higher compared with patients with structural heart disease (86 vs. 74 %, p = 0.002). All patients were discharged alive after a median of 3 days. No patient suffered an acute myocardial infarction, stroke, or major bleeding. After 12 months' follow-up, 99 % of patients were still alive showing a significant different mortality between patients with structural heart disease compared with those without (2.3 vs. 0 %, p = 0.012). In addition, 76 % of patients showed significantly improved symptoms after 12 months of follow-up. CONCLUSION: Based on the data from this registry, ablation of PVCs is a safe and efficient procedure with an excellent outcome and improved symptoms after 12 months.
Entities:
Keywords:
Ablation; Left ventricular outflow tract; PVC; Premature ventricular contraction; Registry; Right ventricular outflow tract
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