Eda Kaya1, Dogac Demir, Yesim O Alahdab, Yusuf Yilmaz. 1. aSchool of Medicine bDepartment of Gastroenterology, School of Medicine cInstitute of Gastroenterology, Marmara University, Istanbul, Turkey.
Abstract
OBJECTIVE: Despite the increasing burden of nonalcoholic fatty liver disease (NAFLD) in modern societies, the optimal screening method to detect hepatic steatosis in the general population remains to be established. Controlled attenuation parameter (CAP) measured with transient elastography (TE) has recently emerged as a reliable imaging tool for the screening and diagnosis of NAFLD. Here, we sought to investigate the prevalence of TE-defined hepatic steatosis in a sample of apparently healthy medical students. We also assessed the relationships between CAP and traditional NAFLD risk factors. MATERIALS AND METHODS: A total of 112 Turkish medical students (48 women and 64 men, mean age 20.5±1.1 years) underwent TE. On the basis of previous studies, a cut-off value of 238 dB/m for CAP was used for the diagnosis of hepatic steatosis. RESULTS: On the basis of the selected cut-off for CAP, we identified 26 students (23.2%) with TE-defined NAFLD. Univariate correlation analyses showed that CAP values were significantly associated with BMI (r=0.40, P<0.001), waist circumference (r=0.39, P<0.001), and hip circumference (r=0.34, P<0.001). In multivariable analysis, only BMI retained its independent association with CAP (β=0.36, t=3.4, P<0.001). CONCLUSION: NAFLD is highly prevalent even in apparently healthy young individuals. CAP assessment with TE may be useful for an early, noninvasive identification of hepatic steatosis.
OBJECTIVE: Despite the increasing burden of nonalcoholic fatty liver disease (NAFLD) in modern societies, the optimal screening method to detect hepatic steatosis in the general population remains to be established. Controlled attenuation parameter (CAP) measured with transient elastography (TE) has recently emerged as a reliable imaging tool for the screening and diagnosis of NAFLD. Here, we sought to investigate the prevalence of TE-defined hepatic steatosis in a sample of apparently healthy medical students. We also assessed the relationships between CAP and traditional NAFLD risk factors. MATERIALS AND METHODS: A total of 112 Turkish medical students (48 women and 64 men, mean age 20.5±1.1 years) underwent TE. On the basis of previous studies, a cut-off value of 238 dB/m for CAP was used for the diagnosis of hepatic steatosis. RESULTS: On the basis of the selected cut-off for CAP, we identified 26 students (23.2%) with TE-defined NAFLD. Univariate correlation analyses showed that CAP values were significantly associated with BMI (r=0.40, P<0.001), waist circumference (r=0.39, P<0.001), and hip circumference (r=0.34, P<0.001). In multivariable analysis, only BMI retained its independent association with CAP (β=0.36, t=3.4, P<0.001). CONCLUSION: NAFLD is highly prevalent even in apparently healthy young individuals. CAP assessment with TE may be useful for an early, noninvasive identification of hepatic steatosis.
Authors: Yusuf Yilmaz; Nimet Yilmaz; Fehmi Ates; Fatih Karakaya; Hale Gokcan; Eda Kaya; Gupse Adali; Aysun Caliskan Kartal; Ilker Sen; Emel Ahishali; Seren Ozenirler; Mehmet Koruk; Ahmet Uygun; Ramazan Idilman Journal: Hepatol Forum Date: 2021-05-21
Authors: Robert Nastasa; Carol Stanciu; Sebastian Zenovia; Ana-Maria Singeap; Camelia Cojocariu; Catalin Sfarti; Irina Girleanu; Stefan Chiriac; Tudor Cuciureanu; Laura Huiban; Cristina-Maria Muzica; Anca Trifan Journal: Diagnostics (Basel) Date: 2021-12-13