Mandy B Belfort1, Peter J Anderson2, Victoria A Nowak3, Katherine J Lee2, Charlotte Molesworth2, Deanne K Thompson4, Lex W Doyle5, Terrie E Inder6. 1. Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, MA. Electronic address: mbrown9@partners.org. 2. Murdoch Childrens Research Institute, Melbourne, Australia; Department of Pediatrics, University of Melbourne, Melbourne, Australia. 3. St. John's College, University of Cambridge, Cambridge, United Kingdom. 4. Murdoch Childrens Research Institute, Melbourne, Australia; Department of Pediatrics, University of Melbourne, Melbourne, Australia; Florey Institute of Neuroscience and Mental Health, Melbourne, Australia. 5. Murdoch Childrens Research Institute, Melbourne, Australia; Department of Pediatrics, University of Melbourne, Melbourne, Australia; Department of Obstetrics and Gynecology, The Royal Women's Hospital, University of Melbourne, Melbourne, Australia. 6. Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, MA.
Abstract
OBJECTIVES: To determine the associations of breast milk intake after birth with neurological outcomes at term equivalent and 7 years of age in very preterm infants STUDY DESIGN: We studied 180 infants born at <30 weeks' gestation or <1250 grams birth weight enrolled in the Victorian Infant Brain Studies cohort from 2001-2003. We calculated the number of days on which infants received >50% of enteral intake as breast milk from 0-28 days of life. Outcomes included brain volumes measured by magnetic resonance imaging at term equivalent and 7 years of age, and cognitive (IQ, reading, mathematics, attention, working memory, language, visual perception) and motor testing at 7 years of age. We adjusted for age, sex, social risk, and neonatal illness in linear regression. RESULTS: A greater number of days on which infants received >50% breast milk was associated with greater deep nuclear gray matter volume at term equivalent age (0.15 cc/d; 95% CI, 0.05-0.25); and with better performance at age 7 years of age on IQ (0.5 points/d; 95% CI, 0.2-0.8), mathematics (0.5; 95% CI, 0.1-0.9), working memory (0.5; 95% CI, 0.1-0.9), and motor function (0.1; 95% CI, 0.0-0.2) tests. No differences in regional brain volumes at 7 years of age in relation to breast milk intake were observed. CONCLUSION: Predominant breast milk feeding in the first 28 days of life was associated with a greater deep nuclear gray matter volume at term equivalent age and better IQ, academic achievement, working memory, and motor function at 7 years of age in very preterm infants.
OBJECTIVES: To determine the associations of breast milk intake after birth with neurological outcomes at term equivalent and 7 years of age in very preterm infants STUDY DESIGN: We studied 180 infants born at <30 weeks' gestation or <1250 grams birth weight enrolled in the Victorian Infant Brain Studies cohort from 2001-2003. We calculated the number of days on which infants received >50% of enteral intake as breast milk from 0-28 days of life. Outcomes included brain volumes measured by magnetic resonance imaging at term equivalent and 7 years of age, and cognitive (IQ, reading, mathematics, attention, working memory, language, visual perception) and motor testing at 7 years of age. We adjusted for age, sex, social risk, and neonatal illness in linear regression. RESULTS: A greater number of days on which infants received >50% breast milk was associated with greater deep nuclear gray matter volume at term equivalent age (0.15 cc/d; 95% CI, 0.05-0.25); and with better performance at age 7 years of age on IQ (0.5 points/d; 95% CI, 0.2-0.8), mathematics (0.5; 95% CI, 0.1-0.9), working memory (0.5; 95% CI, 0.1-0.9), and motor function (0.1; 95% CI, 0.0-0.2) tests. No differences in regional brain volumes at 7 years of age in relation to breast milk intake were observed. CONCLUSION: Predominant breast milk feeding in the first 28 days of life was associated with a greater deep nuclear gray matter volume at term equivalent age and better IQ, academic achievement, working memory, and motor function at 7 years of age in very preterm infants.
Authors: E B Isaacs; A Lucas; W K Chong; S J Wood; C L Johnson; C Marshall; F Vargha-Khadem; D G Gadian Journal: Pediatr Res Date: 2000-06 Impact factor: 3.756
Authors: Betty R Vohr; Brenda B Poindexter; Anna M Dusick; Leslie T McKinley; Linda L Wright; John C Langer; W Kenneth Poole Journal: Pediatrics Date: 2006-07 Impact factor: 7.124
Authors: Mandy B Belfort; Sheryl L Rifas-Shiman; Ken P Kleinman; Lauren B Guthrie; David C Bellinger; Elsie M Taveras; Matthew W Gillman; Emily Oken Journal: JAMA Pediatr Date: 2013-09 Impact factor: 16.193
Authors: Betty R Vohr; Brenda B Poindexter; Anna M Dusick; Leslie T McKinley; Rosemary D Higgins; John C Langer; W Kenneth Poole Journal: Pediatrics Date: 2007-10 Impact factor: 7.124
Authors: Elizabeth B Isaacs; Bruce R Fischl; Brian T Quinn; Wui K Chong; David G Gadian; Alan Lucas Journal: Pediatr Res Date: 2010-04 Impact factor: 3.756
Authors: Sean C L Deoni; Douglas C Dean; Irene Piryatinsky; Jonathan O'Muircheartaigh; Nicole Waskiewicz; Katie Lehman; Michelle Han; Holly Dirks Journal: Neuroimage Date: 2013-05-28 Impact factor: 6.556
Authors: Jessica Liu; Margaret G Parker; Tianyao Lu; Shannon M Conroy; John Oehlert; Henry C Lee; Scarlett Lin Gomez; Salma Shariff-Marco; Jochen Profit Journal: J Pediatr Date: 2019-12-13 Impact factor: 4.406
Authors: J Wang; T Johnson; L Sahin; M S Tassinari; P O Anderson; T E Baker; C Bucci-Rechtweg; G J Burckart; C D Chambers; T W Hale; D Johnson-Lyles; R M Nelson; C Nguyen; D Pica-Branco; Z Ren; H Sachs; J Sauberan; A Zajicek; S Ito; L P Yao Journal: Clin Pharmacol Ther Date: 2017-06 Impact factor: 6.875
Authors: Zheng Liu; Martha Neuringer; John W Erdman; Matthew J Kuchan; Lauren Renner; Emily E Johnson; Xiaojie Wang; Christopher D Kroenke Journal: Neuroimage Date: 2018-09-07 Impact factor: 6.556