Abbas Akhgari1, Ali Tavakol2. 1. Targeted Drug Delivery Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. 2. Nanotechnology Research Center and School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Abstract
PURPOSE: The physicochemical properties of free films made from different mixtures of sustained release polymers were investigated, and an optimum formulation coating on drug containing pellets, based on the study of free film was evaluated. METHODS: In order to determine the effect of different variables on the permeability and swelling of films and procedure optimization, the experimental design was fulfilled based on the statistical method of a 3(3) full factorial design, and according to this method 27 formulations were prepared. The films were prepared using casting-solvent evaporation method. Water vapor permeability, the swelling and permeability of free films in both acidic and buffer media, were carried out. Then, the pellets containing theophylline were coated with the optimum formulation. RESULTS: The results of this study demonstrated that an increase in the free film thickness and Eurdragit RS ratio in films lowered the water vapor transmission (WVT), the swelling and the permeability of all formulations, while an increase in the quantity of ethylcellulose, up to a specific ratio (approximately 40%), decreased the permeability and swelling. The most optimum free film formulation was made up of 60% Eudragit RS and 40% ethylcellulose. CONCLUSION: Pellets coated with a 10% coating level of ethylcellulose and Eudragit RS (4:6) showed suitable release properties and could serve as a favorable sustained release system for theophylline.
PURPOSE: The physicochemical properties of free films made from different mixtures of sustained release polymers were investigated, and an optimum formulation coating on drug containing pellets, based on the study of free film was evaluated. METHODS: In order to determine the effect of different variables on the permeability and swelling of films and procedure optimization, the experimental design was fulfilled based on the statistical method of a 3(3) full factorial design, and according to this method 27 formulations were prepared. The films were prepared using casting-solvent evaporation method. Water vapor permeability, the swelling and permeability of free films in both acidic and buffer media, were carried out. Then, the pellets containing theophylline were coated with the optimum formulation. RESULTS: The results of this study demonstrated that an increase in the free film thickness and Eurdragit RS ratio in films lowered the water vapor transmission (WVT), the swelling and the permeability of all formulations, while an increase in the quantity of ethylcellulose, up to a specific ratio (approximately 40%), decreased the permeability and swelling. The most optimum free film formulation was made up of 60% Eudragit RS and 40% ethylcellulose. CONCLUSION: Pellets coated with a 10% coating level of ethylcellulose and Eudragit RS (4:6) showed suitable release properties and could serve as a favorable sustained release system for theophylline.
Authors: Zhi-wei Ye; Patrick Rombout; Jean Paul Remon; Chris Vervaet; Guy Van den Mooter Journal: Eur J Pharm Biopharm Date: 2007-02-21 Impact factor: 5.571
Authors: M Haaser; Y Karrout; C Velghe; Y Cuppok; K C Gordon; M Pepper; J Siepmann; T Rades; P F Taday; C J Strachan Journal: Int J Pharm Date: 2013-05-27 Impact factor: 5.875
Authors: Malvika Verma; Karan Vishwanath; Feyisope Eweje; Niclas Roxhed; Tyler Grant; Macy Castaneda; Christoph Steiger; Hormoz Mazdiyasni; Taylor Bensel; Daniel Minahan; Vance Soares; John A F Salama; Aaron Lopes; Kaitlyn Hess; Cody Cleveland; Daniel J Fulop; Alison Hayward; Joy Collins; Siddartha M Tamang; Tiffany Hua; Chinonyelum Ikeanyi; Gal Zeidman; Elizabeth Mule; Sooraj Boominathan; Ellena Popova; Jonathan B Miller; Andrew M Bellinger; David Collins; Dalia Leibowitz; Shelly Batra; Sandeep Ahuja; Manju Bajiya; Sonali Batra; Rohit Sarin; Upasna Agarwal; Sunil D Khaparde; Neeraj K Gupta; Deepak Gupta; Anuj K Bhatnagar; Kamal K Chopra; Nandini Sharma; Ashwani Khanna; Jayeeta Chowdhury; Robert Stoner; Alexander H Slocum; Michael J Cima; Jennifer Furin; Robert Langer; Giovanni Traverso Journal: Sci Transl Med Date: 2019-03-13 Impact factor: 17.956
Authors: Mohammed Jafar; Mohammed Salahuddin; Mohd Sajjad Ahmad Khan; Yasir Alshehry; Nazar Radwan Alrwaili; Yazeed Ali Alzahrani; Syed Sarim Imam; Sultan Alshehri Journal: Pharmaceutics Date: 2021-12-06 Impact factor: 6.321