Literature DB >> 27478488

A Duty To Warn Relatives in Clinical Genetics: Arguably 'Fair just and reasonable' in English Law?

C Mitchell1, M C Ploem2, R C M Hennekam3, J Kaye4.   

Abstract

The use of 'next-generation' genetic sequencing technology that allows the sequencing of large parts, or even the entirety, of a patient's genome is advancing rapidly in the UK and around the world. This is set to greatly increase the level of health information that will be of relevance to relatives and the latest medical guidance advises that there is a professional duty to consider warning a patient's relatives of a serious genetic risk in limited circumstances. However, the High Court in ABC v St George's Healthcare NHS Trust [2015] EWHC 1394 (QB), recently found that a legal duty on the part of doctors to warn a patient's daughter of a genetic risk of Huntington's Disease without the patient's consent, was not even 'reasonably arguable' and would not be 'fair, just and reasonable'. This article considers the courts' approach to a duty of care towards 'third parties' in this context and concludes that some form of a duty of care to genetic relatives in clinical genetics is at very least arguably 'fair, just and reasonable'.

Entities:  

Year:  2016        PMID: 27478488      PMCID: PMC4962911     

Source DB:  PubMed          Journal:  Tottels J Prof Neglig        ISSN: 1746-6709


  10 in total

1.  Genetic secrets and the family.

Authors:  D Bell; B Bennett
Journal:  Med Law Rev       Date:  2001       Impact factor: 1.267

Review 2.  Genetic information: a joint account?

Authors:  Michael Parker; Anneke M Lucassen
Journal:  BMJ       Date:  2004-07-17

3.  Consent and confidentiality in clinical genetic practice: guidance on genetic testing and sharing genetic information.

Authors:  Anneke Lucassen; Alison Hall
Journal:  Clin Med (Lond)       Date:  2012-02       Impact factor: 2.659

4.  Recognizing the Right Not to Know: Conceptual, Professional, and Legal Implications.

Authors:  Graeme Laurie
Journal:  J Law Med Ethics       Date:  2014       Impact factor: 1.718

5.  AB v Leeds Teaching Hospital NHS Trust.

Authors: 
Journal:  Fam Law Rep       Date:  2004

6.  Handling unsolicited findings in clinical care: a legal perspective.

Authors:  Corrette Ploem
Journal:  Eur J Health Law       Date:  2014-12

7.  Doctors have a duty to breach patient confidentiality to protect others at risk of HIV infection.

Authors:  Tak Kwong Chan
Journal:  BMJ       Date:  2013-03-06

8.  A framework for analyzing the ethics of disclosing genetic research findings.

Authors:  Lisa Eckstein; Jeremy R Garrett; Benjamin E Berkman
Journal:  J Law Med Ethics       Date:  2014       Impact factor: 1.718

Review 9.  Health-care professionals' responsibility to patients' relatives in genetic medicine: a systematic review and synthesis of empirical research.

Authors:  Sandi Dheensa; Angela Fenwick; Shiri Shkedi-Rafid; Gillian Crawford; Anneke Lucassen
Journal:  Genet Med       Date:  2015-06-25       Impact factor: 8.822

10.  The challenges of genome analysis in the health care setting.

Authors:  Anneke Lucassen; Richard S Houlston
Journal:  Genes (Basel)       Date:  2014-07-22       Impact factor: 4.096

  10 in total
  9 in total

Review 1.  A pediatric perspective on genomics and prevention in the twenty-first century.

Authors:  Bimal P Chaudhari; Kandamurugu Manickam; Kim L McBride
Journal:  Pediatr Res       Date:  2019-10-02       Impact factor: 3.756

2.  Limitations and Pitfalls of Using Family Letters to Communicate Genetic Risk: a Qualitative Study with Patients and Healthcare Professionals.

Authors:  Sandi Dheensa; Anneke Lucassen; Angela Fenwick
Journal:  J Genet Couns       Date:  2017-11-01       Impact factor: 2.537

3.  Using a genetic test result in the care of family members: how does the duty of confidentiality apply?

Authors:  Michael Parker; Anneke Lucassen
Journal:  Eur J Hum Genet       Date:  2018-04-27       Impact factor: 4.246

4.  A tailored approach towards informing relatives at risk of inherited cardiac conditions: study protocol for a randomised controlled trial.

Authors:  Lieke M van den Heuvel; Yvonne M Hoedemaekers; Annette F Baas; J Peter van Tintelen; Ellen M A Smets; Imke Christiaans
Journal:  BMJ Open       Date:  2019-07-09       Impact factor: 2.692

5.  "It would be so much easier": health system-led genetic risk notification-feasibility and acceptability of cascade screening in an integrated system.

Authors:  Nora B Henrikson; Paula R Blasi; Stephanie M Fullerton; Jane Grafton; Kathleen A Leppig; Gail P Jarvik; Eric B Larson
Journal:  J Community Genet       Date:  2019-03-06

6.  Familial genetic risks: how can we better navigate patient confidentiality and appropriate risk disclosure to relatives?

Authors:  Edward S Dove; Vicky Chico; Michael Fay; Graeme Laurie; Anneke M Lucassen; Emily Postan
Journal:  J Med Ethics       Date:  2019-05-23       Impact factor: 2.903

7.  Long-Term Follow-Up Study on the Uptake of Genetic Counseling and Predictive DNA Testing in Inherited Cardiac Conditions.

Authors:  Lieke M van den Heuvel; Maxiem O van Teijlingen; Wilma van der Roest; Irene M van Langen; Ellen M A Smets; J Peter van Tintelen; Imke Christiaans
Journal:  Circ Genom Precis Med       Date:  2020-08-14

8.  A genetic researcher's devil's dilemma: Warn relatives about their genetic risk or respect confidentiality agreements with research participants?

Authors:  Els L M Maeckelberghe; M Corrette Ploem; Imke Christiaans; Lieke M van den Heuvel
Journal:  BMC Med Ethics       Date:  2021-11-23       Impact factor: 2.652

9.  Comment on Informing relatives of their genetic risk: an examination of the Belgian context.

Authors:  Aisling de Paor
Journal:  Eur J Hum Genet       Date:  2022-03-01       Impact factor: 5.351

  9 in total

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