Literature DB >> 27477644

Search for New Bioactive Marine Natural Products and Application to Drug Development.

Jun'ichi Kobayashi1.   

Abstract

Natural products are well recognized as an important source of lead compounds in drug development. During the past >30 years, we have discovered >1000 novel bioactive natural products from Okinawan marine organisms (sponges, tunicates, cone shells, etc.) and microorganisms (fungi, bacteria, dinoflagellates, etc.). Some of them are used as bioprobes useful for basic studies of life sciences, while others are expected to be candidates of drug leads.

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Year:  2016        PMID： 27477644     DOI： 10.1248/cpb.c16-00281

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  12 in total

1.  The Marine Dinoflagellate Alexandrium andersoni Induces Cell Death in Lung and Colorectal Tumor Cell Lines.

Authors:  Clementina Sansone; Genoveffa Nuzzo; Christian Galasso; Raffaella Casotti; Angelo Fontana; Giovanna Romano; Adrianna Ianora
Journal:  Mar Biotechnol (NY)       Date:  2018-04-20       Impact factor: 3.619

Review 2.  Phytoplankton Toxins and Their Potential Therapeutic Applications: A Journey toward the Quest for Potent Pharmaceuticals.

Authors:  Biswajita Pradhan; Jang-Seu Ki
Journal:  Mar Drugs       Date:  2022-04-18       Impact factor: 6.085

Review 3.  Dactylospongia elegans-A Promising Drug Source: Metabolites, Bioactivities, Biosynthesis, Synthesis, and Structural-Activity Relationship.

Authors:  Sabrin R M Ibrahim; Sana A Fadil; Haifa A Fadil; Rawan H Hareeri; Sultan O Alolayan; Hossam M Abdallah; Gamal A Mohamed
Journal:  Mar Drugs       Date:  2022-03-23       Impact factor: 6.085

4.  Fungi associated with mesophotic macroalgae from the 'Au'au Channel, west Maui are differentiated by host and overlap terrestrial communities.

Authors:  Benjamin J Wainwright; Geoffrey L Zahn; Heather L Spalding; Alison R Sherwood; Celia M Smith; Anthony S Amend
Journal:  PeerJ       Date:  2017-07-11       Impact factor: 2.984

5.  Bioactive Diphenyl Ethers and Isocoumarin Derivatives from a Gorgonian-Derived Fungus Phoma sp. (TA07-1).

Authors:  Ting Shi; Jun Qi; Chang-Lun Shao; Dong-Lin Zhao; Xue-Mei Hou; Chang-Yun Wang
Journal:  Mar Drugs       Date:  2017-05-25       Impact factor: 5.118

Review 6.  Biotechnological and Pharmacological Applications of Biotoxins and Other Bioactive Molecules from Dinoflagellates.

Authors:  Joana Assunção; A Catarina Guedes; F Xavier Malcata
Journal:  Mar Drugs       Date:  2017-12-20       Impact factor: 5.118

7.  Marine bisindole alkaloid: A potential apoptotic inducer in human cancer cells.

Authors:  Sara Salucci; Sabrina Burattini; Francesca Buontempo; Ester Orsini; Lucia Furiassi; Michele Mari; Simone Lucarini; Alberto M Martelli; Elisabetta Falcieri
Journal:  Eur J Histochem       Date:  2018-04-10       Impact factor: 3.188

8.  Naphthoquinone-Based Meroterpenoids from Marine-Derived Streptomyces sp. B9173.

Authors:  Xinqian Shen; Xiaozheng Wang; Tingting Huang; Zixin Deng; Shuangjun Lin
Journal:  Biomolecules       Date:  2020-08-15

9.  Xanthones and Quinolones Derivatives Produced by the Deep-Sea-Derived Fungus Penicillium sp. SCSIO Ind16F01.

Authors:  Feng-An Liu; Xiuping Lin; Xuefeng Zhou; Minghao Chen; Xiuling Huang; Bin Yang; Huaming Tao
Journal:  Molecules       Date:  2017-12-07       Impact factor: 4.411

10.  Discovery of Two Brominated Oxindole Alkaloids as Staphylococcal DNA Gyrase and Pyruvate Kinase Inhibitors via Inverse Virtual Screening.

Authors:  Ahmed M Sayed; Hani A Alhadrami; Seham S El-Hawary; Rabab Mohammed; Hossam M Hassan; Mostafa E Rateb; Usama Ramadan Abdelmohsen; Walid Bakeer
Journal:  Microorganisms       Date:  2020-02-20
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