Fabienne Cyprien1, Nicolas Menjot de Champfleur2, Jérémy Deverdun3, Emilie Olié1, Emmanuelle Le Bars4, Alain Bonafé2, Thibault Mura5, Fabrice Jollant6, Philippe Courtet7, Sylvaine Artero8. 1. Inserm, U1061, La Colombière Hospital, Montpellier F-34093, France; University of Montpellier, Montpellier F-34000, France; CHRU Montpellier, Montpellier F-34093, France. 2. University of Montpellier, Montpellier F-34000, France; CHRU Montpellier, Montpellier F-34093, France. 3. University of Montpellier, Montpellier F-34000, France; CHRU Montpellier, Montpellier F-34093, France; CNRS, UMR 5221, Montpellier F-34093, France. 4. CHRU Montpellier, Montpellier F-34093, France. 5. Inserm, U1061, La Colombière Hospital, Montpellier F-34093, France; University of Montpellier, Montpellier F-34000, France; CHRU Montpellier, Montpellier F-34093, France; CIC 1001, Montpellier F-34000, France. 6. McGill University, Department of Psychiatry, Canada; Douglas Mental Health University Institute, McGill Group for Suicide Studies, Montréal, Québec, Canada. 7. Inserm, U1061, La Colombière Hospital, Montpellier F-34093, France; University of Montpellier, Montpellier F-34000, France; CHRU Montpellier, Montpellier F-34093, France; Fondamental Foundation, France. Electronic address: sylvaine.artero@inserm.fr. 8. Inserm, U1061, La Colombière Hospital, Montpellier F-34093, France; University of Montpellier, Montpellier F-34000, France. Electronic address: sylvaine.artero@inserm.fr.
Abstract
BACKGROUND: Some MRI studies have noted alterations in the corpus callosum (CC) white matter integrity of individuals with mood disorders and also in patients with suicidal behavior. We investigated the specific impact of suicidal behavior on CC integrity in mood disorders. METHODS: CC structural changes were assessed by diffusion tensor imaging (DTI) in 121 women 18-50-year-old): 41 with bipolar disorder (BD), 50 with major depressive disorder (MDD) and 30 healthy controls (HC). Fractional anisotropy (FA) and DTI metrics were calculated for the genu, body and splenium of CC and compared in the three groups by MANCOVA. Then, they were re-analyzed relative to the suicide attempt history within the MDD and BD groups and to the suicide number/severity. RESULTS: FA values for the CC genu and body were lower in non-suicide attempters with BD than with MDD and in HC. Conversely, FA values for all CC regions were significantly lower in suicide attempters with BD than in HC. Finally, higher number of suicide attempts (>2) and elevated Suicidal Intent Scale score were associated with significant splenium alterations. LIMITATIONS: Limitations include the cross-sectional design (non-causal study), the potential influence of medications and concerns about the generalizability to men. CONCLUSION: Genu and body are altered in non-suicide attempters with BD, while splenium is specifically altered in suicide attempters, independently from their psychiatric status. History of suicide attempts may be a source of heterogeneity in the association between CC alterations and BD and may partially explain the variable results of previous studies.
BACKGROUND: Some MRI studies have noted alterations in the corpus callosum (CC) white matter integrity of individuals with mood disorders and also in patients with suicidal behavior. We investigated the specific impact of suicidal behavior on CC integrity in mood disorders. METHODS: CC structural changes were assessed by diffusion tensor imaging (DTI) in 121 women 18-50-year-old): 41 with bipolar disorder (BD), 50 with major depressive disorder (MDD) and 30 healthy controls (HC). Fractional anisotropy (FA) and DTI metrics were calculated for the genu, body and splenium of CC and compared in the three groups by MANCOVA. Then, they were re-analyzed relative to the suicide attempt history within the MDD and BD groups and to the suicide number/severity. RESULTS: FA values for the CC genu and body were lower in non-suicide attempters with BD than with MDD and in HC. Conversely, FA values for all CC regions were significantly lower in suicide attempters with BD than in HC. Finally, higher number of suicide attempts (>2) and elevated Suicidal Intent Scale score were associated with significant splenium alterations. LIMITATIONS: Limitations include the cross-sectional design (non-causal study), the potential influence of medications and concerns about the generalizability to men. CONCLUSION: Genu and body are altered in non-suicide attempters with BD, while splenium is specifically altered in suicide attempters, independently from their psychiatric status. History of suicide attempts may be a source of heterogeneity in the association between CC alterations and BD and may partially explain the variable results of previous studies.
Authors: Elizabeth T Cox Lippard; Jennifer A Y Johnston; Linda Spencer; Susan Quatrano; Siyan Fan; Anjali Sankar; Judah Weathers; Brian Pittman; Maria A Oquendo; Hilary P Blumberg Journal: J Affect Disord Date: 2018-11-28 Impact factor: 4.839
Authors: João Paulo Lima Santos; David Brent; Michele Bertocci; Sarrah Mailliard; Genna Bebko; Tina Goldstein; Tae Kim; Satish Iyengar; Danella Hafeman; Vilde Chaya Fenster-Ehrlich; Alexander Skeba; Lisa Bonar; Halimah Abdul-Waalee; MaryKay Gill; John Merranko; Boris Birmaher; Mary L Phillips; Amelia Versace Journal: Biol Psychiatry Cogn Neurosci Neuroimaging Date: 2020-07-18