| Literature DB >> 27468714 |
Hui Pan1, Hongyan Ni1, LeiLei Zhang1, Yue Xing1, Jiayan Fan1, Peng Li1, Tianyuan Li1, Renbing Jia1, Shengfang Ge1, He Zhang2, Xianqun Fan3.
Abstract
Uveal melanoma (UM) has a high mortality rate for primary intraocular tumors. Approximately half of UM patients present with untreatable and fatal metastases. Long non-coding RNAs (lncRNAs) have emerged as potent regulatory RNAs that play key roles in various cellular processes and tumorigenesis. However, to date, their roles in UM are not well-known. Here, we identified a transcriptional variant transcribed from the P2RX7 gene locus, named P2RX7-V3 (P2RX7 variant 3), which was expressed at a high level in UM cells. P2RX7-V3 silencing revealed that this variant acts as a necessary UM oncoRNA. Knockdown of P2RX7-V3 expression significantly suppressed tumor growth in vitro and in vivo. A genome-wide cDNA array revealed that a variety of genes were dysregulated following P2RX7-V3 silencing. These observations identified P2RX7-V3 that plays a crucial role in UM tumorigenesis and may serve as a useful biomarker in the diagnosis and prognosis treatment of UM in the future.Entities:
Keywords: Metastasis; P2RX7; Uveal melanoma; Variant; lncRNA; oncoRNA
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Year: 2016 PMID： 27468714 DOI： 10.1007/s13277-016-5141-8
Source DB: PubMed Journal: Tumour Biol ISSN： 1010-4283