| Literature DB >> 24768205 |
Ji-hang Yuan1, Fu Yang1, Fang Wang1, Jin-zhao Ma1, Ying-jun Guo1, Qi-fei Tao2, Feng Liu1, Wei Pan1, Tian-tian Wang1, Chuan-chuan Zhou1, Shao-bing Wang1, Yu-zhao Wang1, Yuan Yang2, Ning Yang3, Wei-ping Zhou2, Guang-shun Yang3, Shu-han Sun4.
Abstract
The role of TGF-β-induced epithelial-mesenchymal transition (EMT) in cancer cell dissemination is well established, but the involvement of lncRNAs in TGF-β signaling is still unknown. In this study, we observed that the lncRNA-activated by TGF-β (lncRNA-ATB) was upregulated in hepatocellular carcinoma (HCC) metastases and associated with poor prognosis. lncRNA-ATB upregulated ZEB1 and ZEB2 by competitively binding the miR-200 family and then induced EMT and invasion. In addition, lncRNA-ATB promoted organ colonization of disseminated tumor cells by binding IL-11 mRNA, autocrine induction of IL-11, and triggering STAT3 signaling. Globally, lncRNA-ATB promotes the invasion-metastasis cascade. Thus, these findings suggest that lncRNA-ATB, a mediator of TGF-β signaling, could predispose HCC patients to metastases and may serve as a potential target for antimetastatic therapies.Entities:
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Year: 2014 PMID： 24768205 DOI： 10.1016/j.ccr.2014.03.010
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743