Ryuichi Kumashiro1, Kozo Konishi2, Tohru Chiba3, Tomohiko Akahoshi4, Shotaro Nakamura5, Masaharu Murata4, Morimasa Tomikawa1, Takayuki Matsumoto5, Yoshihiko Maehara2, Makoto Hashizume6. 1. Center for Integration of Advanced Medicine, Life Science and Innovative Technology, Kyushu University, Fukuoka, Japan Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. 2. Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. 3. PENTAX Lifecare Division, Hoya Corporation, Tokyo, Japan. 4. Department of Disaster and Emergency Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. 5. Second Department of Internal Medicine Kyushu University Hospital, Fukuoka, Japan. 6. Center for Integration of Advanced Medicine, Life Science and Innovative Technology, Kyushu University, Fukuoka, Japan Second Department of Internal Medicine Kyushu University Hospital, Fukuoka, Japan mhashi@dem.med.kyushu-u.ac.jp.
Abstract
BACKGROUND/AIM: Two-dimensional hyperspectral data systems with enhanced area detection and diagnostic abilities are now available in gastrointestinal endoscopy for colorectal cancer. We evaluated a new hyperspectral system for diagnosis of colorectal cancer. PATIENTS AND METHODS: A resected-specimen spectrum observation module (stereoscopic macroscope, hyperspectral camera, and xenon lamp) was used to evaluate 21 resected colorectal cancer specimens (ex vivo experiment). A colonoscopy spectrum observation module (imaging fiberscope and hyperspectral camera) was used to perform 24 colonoscopic spectroscopy evaluations (in vivo experiment). RESULTS: An approximately 525-nm increase in spectral absorption occurred between normal mucosa and adenoma, with a tendency toward decreased absorption rates with aggravation of other tumor types. In vivo discrimination between tumorous and non-tumorous tissues showed 72.5% sensitivity and 82.1% specificity. CONCLUSION: This in vivo hyperspectral diagnostic system showed that reflectance spectra intensity may discriminate between normal and abnormal colonic mucosa. Copyright
BACKGROUND/AIM: Two-dimensional hyperspectral data systems with enhanced area detection and diagnostic abilities are now available in gastrointestinal endoscopy for colorectal cancer. We evaluated a new hyperspectral system for diagnosis of colorectal cancer. PATIENTS AND METHODS: A resected-specimen spectrum observation module (stereoscopic macroscope, hyperspectral camera, and xenon lamp) was used to evaluate 21 resected colorectal cancer specimens (ex vivo experiment). A colonoscopy spectrum observation module (imaging fiberscope and hyperspectral camera) was used to perform 24 colonoscopic spectroscopy evaluations (in vivo experiment). RESULTS: An approximately 525-nm increase in spectral absorption occurred between normal mucosa and adenoma, with a tendency toward decreased absorption rates with aggravation of other tumor types. In vivo discrimination between tumorous and non-tumorous tissues showed 72.5% sensitivity and 82.1% specificity. CONCLUSION: This in vivo hyperspectral diagnostic system showed that reflectance spectra intensity may discriminate between normal and abnormal colonic mucosa. Copyright
Authors: Hannes Köhler; Boris Jansen-Winkeln; Marianne Maktabi; Manuel Barberio; Jonathan Takoh; Nico Holfert; Yusef Moulla; Stefan Niebisch; Michele Diana; Thomas Neumuth; Sebastian M Rabe; Claire Chalopin; Andreas Melzer; Ines Gockel Journal: Surg Endosc Date: 2019-01-23 Impact factor: 4.584
Authors: B Jansen-Winkeln; M Maktabi; J P Takoh; S M Rabe; M Barberio; H Köhler; T Neumuth; A Melzer; C Chalopin; I Gockel Journal: Chirurg Date: 2018-09 Impact factor: 0.955
Authors: Elisabeth J M Baltussen; Henricus J C M Sterenborg; Theo J M Ruers; Behdad Dashtbozorg Journal: Biomed Opt Express Date: 2019-11-05 Impact factor: 3.732