Literature DB >> 27465029

Rapidly progressive neurological deterioration in anti-AMPA receptor encephalitis with additional CRMP5 antibodies.

Shuangshuang Yang1, Jie Qin1, Jinghong Li1, Yuan Gao1, Lu Zhao1, Jun Wu1, Bo Song1, Yuming Xu1, Shilei Sun2.   

Abstract

Anti-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) encephalitis positive for additional onconeural antibodies is rarely reported. Here we report the clinical features of a patient who developed limbic encephalitis with both glutamate receptor 2 (GluR2) and collapsin response mediator protein 5 (CRMP5) antibodies. Brain magnetic resonance imaging revealed multifocal encephalopathy. Chest computed tomography showed a highly suspicious malignant thymoma. He experienced rapid neurological deterioration during hospitalization. This report indicates that the clinical diversity of anti-AMPAR encephalitis and the presence of onconeural antibodies may lead to poor prognosis.

Entities:  

Keywords:  AMPAR; Antibodies; Autoimmune; CRMP5; Encephalitis; Thymoma

Mesh：

Substances：

Year:  2016        PMID： 27465029     DOI： 10.1007/s10072-016-2680-0

Source DB:  PubMed          Journal:  Neurol Sci        ISSN： 1590-1874            Impact factor:   3.307


  5 in total

1.  Encephalitis and AMPA receptor antibodies: Novel findings in a case series of 22 patients.

Authors:  Romana Höftberger; Agnes van Sonderen; Frank Leypoldt; David Houghton; Michael Geschwind; Jeffrey Gelfand; Mercedes Paredes; Lidia Sabater; Albert Saiz; Maarten J Titulaer; Francesc Graus; Josep Dalmau
Journal:  Neurology       Date:  2015-05-15       Impact factor: 9.910

2.  Neuronal surface antigen antibodies in limbic encephalitis: clinical-immunologic associations.

Authors:  F Graus; A Saiz; M Lai; J Bruna; F López; L Sabater; Y Blanco; M J Rey; T Ribalta; J Dalmau
Journal:  Neurology       Date:  2008-09-16       Impact factor: 9.910

Review 3.  Encephalitis and GABAB receptor antibodies: novel findings in a new case series of 20 patients.

Authors:  Romana Höftberger; Maarten J Titulaer; Lidia Sabater; Balazs Dome; Anita Rózsás; Balazs Hegedus; Mir Alireza Hoda; Viktoria Laszlo; Hendrik Jan Ankersmit; Lutz Harms; Sabas Boyero; Alicia de Felipe; Albert Saiz; Josep Dalmau; Francesc Graus
Journal:  Neurology       Date:  2013-09-25       Impact factor: 9.910

4.  AMPA receptor antibodies in limbic encephalitis alter synaptic receptor location.

Authors:  Meizan Lai; Ethan G Hughes; Xiaoyu Peng; Lei Zhou; Amy J Gleichman; Huidy Shu; Sabrina Matà; Daniel Kremens; Roberta Vitaliani; Michael D Geschwind; Luis Bataller; Robert G Kalb; Rebecca Davis; Francesc Graus; David R Lynch; Rita Balice-Gordon; Josep Dalmau
Journal:  Ann Neurol       Date:  2009-04       Impact factor: 10.422

Review 5.  Limbic encephalitis and variants: classification, diagnosis and treatment.

Authors:  Erdem Tüzün; Josep Dalmau
Journal:  Neurologist       Date:  2007-09       Impact factor: 1.398
  5 in total
  6 in total

1.  Fulminant thymomatous AMPAR-antibody limbic encephalitis with hypertonic coma, bruxism, an isoelectric electroencephalogram and temporal cortical atrophy, with recovery.

Authors:  Nicolás Urriola; Kavie Soosapilla; James Drummond; Mark Thieben
Journal:  BMJ Case Rep       Date:  2019-02-21

2.  Anti-CV2 Autoimmune Encephalitis With Parkinson-Like Symptoms and Bilateral Leukoencephalopathy-A Case Report.

Authors:  Xuan Wu; Huayan Wang; Guorong Xu; Yu Lin
Journal:  Front Neurol       Date:  2019-10-09       Impact factor: 4.003

3.  Limbic encephalitis associated with AMPA receptor and CRMP5 antibodies: A case report and literature review.

Authors:  Yujuan Jia; Jie Wang; Lanping Xue; Yuli Hou
Journal:  Brain Behav       Date:  2020-01-28       Impact factor: 2.708

4.  Autoimmune Encephalitis With Psychotic Manifestations and Cognitive Impairment Presenting as Schizophrenia: Case Report and Literature Review.

Authors:  Yuanyuan Luo; Jieying Li; Fugui Jiang; Arui Tan; Xiaohong Qin; Xiaoqiang Xiao; Zuxing Wang; Peijia Wang; Yang Yi; Juan Li; Shuai Yuan; Lei Liu; Jun Xiao
Journal:  Front Psychiatry       Date:  2022-02-14       Impact factor: 4.157

Review 5.  Anti-Alpha-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid Receptor Encephalitis: A Review.

Authors:  Tian-Yi Zhang; Meng-Ting Cai; Yang Zheng; Qi-Lun Lai; Chun-Hong Shen; Song Qiao; Yin-Xi Zhang
Journal:  Front Immunol       Date:  2021-05-21       Impact factor: 7.561

6.  Thymoma and Autoimmune Encephalitis: Clinical Manifestations and Antibodies.

Authors:  Mar Guasp; Jon Landa; Eugenia Martinez-Hernandez; Lidia Sabater; Takahiro Iizuka; Mateus Simabukuro; Masataka Nakamura; Makoto Kinoshita; Masanori Kurihara; Kenichi Kaida; Jordi Bruna; Solange Kapetanovic; Pedro Sánchez; Raquel Ruiz-García; Laura Naranjo; Jesús Planagumà; Amaia Muñoz-Lopetegi; Luis Bataller; Albert Saiz; Josep Dalmau; Francesc Graus
Journal:  Neurol Neuroimmunol Neuroinflamm       Date:  2021-07-23
  6 in total

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