Joseph R Stevens1, Monica L Kearney2, Marie-Pierre St-Onge3,4, Kimber L Stanhope5,6, Peter J Havel5,6, Jill A Kanaley2, John P Thyfault7, Edward P Weiss8, Andrew A Butler1. 1. Department of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, Missouri, USA. 2. Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA. 3. Department of Medicine, New York Obesity Research Center, New York, New York, USA. 4. Institute of Human Nutrition, Columbia University, New York, New York, USA. 5. Department of Molecular Biosciences, School of Veterinary Medicine, University of California-Davis, Davis, California, USA. 6. Department of Nutrition, School of Medicine, University of California-Davis, Davis, California, USA. 7. Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas, USA. 8. Department of Nutrition and Dietetics, Doisy College of Health Sciences of Saint Louis University, St. Louis, Missouri, USA.
Abstract
OBJECTIVE: The role of metabolic condition and diet in regulating circulating levels of adropin, a peptide hormone linked to cardiometabolic control, is not well understood. In this study, weight loss and diet effects on plasma adropin concentrations were examined. METHODS: This report includes data from (1) a weight loss trial, (2) an evaluation of acute exercise effects on mixed-meal (60% kcal from carbohydrates) tolerance test responses, and (3) a meta-analysis to determine normal fasting adropin concentrations. RESULTS: Distribution of plasma adropin concentrations exhibited positive skew and kurtosis. The effect of weight loss on plasma adropin concentrations was dependent on baseline plasma adropin concentrations, with an inverse association between baseline and a decline in concentrations after weight loss (Spearman's ρ = -0.575; P < 0.001). When ranked by baseline plasma adropin concentrations, only values in the upper quartile declined with weight loss. Plasma adropin concentrations under the main area of the bell curve correlated negatively with habitual carbohydrate intake and plasma lipids. There was a negative correlation between baseline values and a transient decline in plasma adropin during the mixed-meal tolerance test. CONCLUSIONS: Plasma adropin concentrations in humans are sensitive to dietary macronutrients, perhaps due to habitual consumption of carbohydrate-rich diets suppressing circulating levels. Very high adropin levels may indicate cardiometabolic conditions sensitive to weight loss.
OBJECTIVE: The role of metabolic condition and diet in regulating circulating levels of adropin, a peptide hormone linked to cardiometabolic control, is not well understood. In this study, weight loss and diet effects on plasma adropin concentrations were examined. METHODS: This report includes data from (1) a weight loss trial, (2) an evaluation of acute exercise effects on mixed-meal (60% kcal from carbohydrates) tolerance test responses, and (3) a meta-analysis to determine normal fasting adropin concentrations. RESULTS: Distribution of plasma adropin concentrations exhibited positive skew and kurtosis. The effect of weight loss on plasma adropin concentrations was dependent on baseline plasma adropin concentrations, with an inverse association between baseline and a decline in concentrations after weight loss (Spearman's ρ = -0.575; P < 0.001). When ranked by baseline plasma adropin concentrations, only values in the upper quartile declined with weight loss. Plasma adropin concentrations under the main area of the bell curve correlated negatively with habitual carbohydrate intake and plasma lipids. There was a negative correlation between baseline values and a transient decline in plasma adropin during the mixed-meal tolerance test. CONCLUSIONS: Plasma adropin concentrations in humans are sensitive to dietary macronutrients, perhaps due to habitual consumption of carbohydrate-rich diets suppressing circulating levels. Very high adropin levels may indicate cardiometabolic conditions sensitive to weight loss.
Authors: K Ganesh Kumar; Jingying Zhang; Su Gao; Jari Rossi; Owen P McGuinness; Heather H Halem; Michael D Culler; Randall L Mynatt; Andrew A Butler Journal: Obesity (Silver Spring) Date: 2012-02-09 Impact factor: 5.002
Authors: Andrew A Butler; Charmaine S Tam; Kimber L Stanhope; Bruce M Wolfe; Mohamed R Ali; Majella O'Keeffe; Marie-Pierre St-Onge; Eric Ravussin; Peter J Havel Journal: J Clin Endocrinol Metab Date: 2012-08-07 Impact factor: 5.958
Authors: Matthew T Flowers; Albert K Groen; Angie Tebon Oler; Mark P Keller; Younjeong Choi; Kathryn L Schueler; Oliver C Richards; Hong Lan; Makoto Miyazaki; Folkert Kuipers; Christina M Kendziorski; James M Ntambi; Alan D Attie Journal: J Lipid Res Date: 2006-09-27 Impact factor: 5.922
Authors: K Ganesh Kumar; James L Trevaskis; Daniel D Lam; Gregory M Sutton; Robert A Koza; Vladimir N Chouljenko; Konstantin G Kousoulas; Pamela M Rogers; Robert A Kesterson; Marie Thearle; Anthony W Ferrante; Randall L Mynatt; Thomas P Burris; Jesse Z Dong; Heather A Halem; Michael D Culler; Lora K Heisler; Jacqueline M Stephens; Andrew A Butler Journal: Cell Metab Date: 2008-12 Impact factor: 27.287
Authors: David Gozal; Leila Kheirandish-Gozal; Rakesh Bhattacharjee; Helena Molero-Ramirez; Hui-Leng Tan; Hari P R Bandla Journal: J Pediatr Date: 2013-06-28 Impact factor: 4.406
Authors: Edward P Weiss; Stewart G Albert; Dominic N Reeds; Kathleen S Kress; Uthayashanker R Ezekiel; Jennifer L McDaniel; Bruce W Patterson; Samuel Klein; Dennis T Villareal Journal: Diabetes Care Date: 2015-04-15 Impact factor: 19.112
Authors: Subhashis Banerjee; Sarbani Ghoshal; Joseph R Stevens; Kyle S McCommis; Su Gao; Mauricio Castro-Sepulveda; Maria L Mizgier; Clemence Girardet; K Ganesh Kumar; Jose E Galgani; Michael L Niehoff; Susan A Farr; Jinsong Zhang; Andrew A Butler Journal: J Biol Chem Date: 2020-07-29 Impact factor: 5.157
Authors: Andrew A Butler; Jinsong Zhang; Candice A Price; Joseph R Stevens; James L Graham; Kimber L Stanhope; Sarah King; Ronald M Krauss; Andrew A Bremer; Peter J Havel Journal: J Biol Chem Date: 2019-04-15 Impact factor: 5.157
Authors: Mariami Jasaszwili; Maria Billert; Mathias Z Strowski; Krzysztof W Nowak; Marek Skrzypski Journal: Molecules Date: 2020-01-27 Impact factor: 4.411
Authors: Sarbani Ghoshal; Joseph R Stevens; Cyrielle Billon; Clemence Girardet; Sadichha Sitaula; Arthur S Leon; D C Rao; James S Skinner; Tuomo Rankinen; Claude Bouchard; Marinelle V Nuñez; Kimber L Stanhope; Deborah A Howatt; Alan Daugherty; Jinsong Zhang; Matthew Schuelke; Edward P Weiss; Alisha R Coffey; Brian J Bennett; Praveen Sethupathy; Thomas P Burris; Peter J Havel; Andrew A Butler Journal: Mol Metab Date: 2017-12-30 Impact factor: 7.422