Hou-you Yu1, Peng Zhao1, Ming-chun Wu2, Jian Liu1, Wen Yin3. 1. Department of Emergency Medicine, Xijing hospital, Fourth Military Medical University, No. 17 Changle West Road, Xi'an 710032, PR China. 2. Department of Anaesthiology, Wuhan general Hospital of Guangzhou Command, No. 627 Wuluo Road, Wuhan, 430070, PR China. 3. Department of Emergency Medicine, Xijing hospital, Fourth Military Medical University, No. 17 Changle West Road, Xi'an 710032, PR China. Electronic address: xijingyinwen@126.com.
Abstract
OBJECTIVE: Adropin is a recently identified bioactive protein that is important for energy homeostasis and maintaining insulin sensitivity. We sought to detect serum adropin levels in acute myocardial infarction (AMI) patients. METHODS: We enrolled 138 AMI patients, 114 stable angina pectoris (SAP) patients and 75 controls. Adropin levels were measured by enzyme-linked immunosorbent assay (ELISA). RESULTS: Serum adropin levels were significantly lower in patients with AMI compared with SAP patients or controls (P<0.01). Multivariate logistic regression demonstrated that lower adropin was the independent predictor for the presence of AMI in coronary artery disease (CAD) patients (P<0.01). Serum adropin levels were negatively associated with body mass index (BMI) (P<0.01) and triglyceride levels (P<0.05) in AMI patients. CONCLUSION: Decreased serum adropin levels are associated with the presence of AMI in CAD patients. These results revealed that adropin might represent as a novel biomarker for predicting AMI onset in CAD patients.
OBJECTIVE:Adropin is a recently identified bioactive protein that is important for energy homeostasis and maintaining insulin sensitivity. We sought to detect serum adropin levels in acute myocardial infarction (AMI) patients. METHODS: We enrolled 138 AMI patients, 114 stable angina pectoris (SAP) patients and 75 controls. Adropin levels were measured by enzyme-linked immunosorbent assay (ELISA). RESULTS: Serum adropin levels were significantly lower in patients with AMI compared with SAPpatients or controls (P<0.01). Multivariate logistic regression demonstrated that lower adropin was the independent predictor for the presence of AMI in coronary artery disease (CAD) patients (P<0.01). Serum adropin levels were negatively associated with body mass index (BMI) (P<0.01) and triglyceride levels (P<0.05) in AMI patients. CONCLUSION: Decreased serum adropin levels are associated with the presence of AMI in CAD patients. These results revealed that adropin might represent as a novel biomarker for predicting AMI onset in CAD patients.
Authors: Joseph R Stevens; Monica L Kearney; Marie-Pierre St-Onge; Kimber L Stanhope; Peter J Havel; Jill A Kanaley; John P Thyfault; Edward P Weiss; Andrew A Butler Journal: Obesity (Silver Spring) Date: 2016-08 Impact factor: 5.002