Literature DB >> 27460082

The anti-oncogenic influence of ellagic acid on colon cancer cells in leptin-enriched microenvironment.

Amany I Yousef1, Omar S El-Masry2, Eman H Yassin1.   

Abstract

Ellagic acid (EA) has been proposed as a promising candidate for therapeutic use in colon cancer. Investigation of the effectiveness of EA in a leptin-enriched model might have been given a little interest. Here in, we investigated the anti-tumor effect of EA in the presence of leptin to reflect on therapeutic use of EA in obesity-linked colon cancer. Proven effective in leptin-enriched microenvironment, EA inhibited cell proliferation of HCT-116 and CaCo-2 cell lines, modulated cell cycle, translocated Bax to the mitochondrial fraction of cells, activated caspase-8, and reduced PCNA expression. The current study findings cast a beam of light on the potential therapeutic use of EA in obesity-related colon carcinogenesis.

Entities:  

Keywords:  Cellular genetics; Colon; Ellagic acid; Leptin

Mesh：

Substances：

Year:  2016        PMID： 27460082     DOI： 10.1007/s13277-016-5284-7

Source DB:  PubMed          Journal:  Tumour Biol        ISSN： 1010-4283


  33 in total

1.  The ellagic acid derivative 4,4'-di-O-methylellagic acid efficiently inhibits colon cancer cell growth through a mechanism involving WNT16.

Authors:  Ana Ramírez de Molina; Teodoro Vargas; Susana Molina; Jenifer Sánchez; Jorge Martínez-Romero; Margarita González-Vallinas; Roberto Martín-Hernández; Ruth Sánchez-Martínez; Marta Gómez de Cedrón; Alberto Dávalos; Luca Calani; Daniele Del Rio; Antonio González-Sarrías; Juan Carlos Espín; Francisco A Tomás-Barberán; Guillermo Reglero
Journal:  J Pharmacol Exp Ther       Date:  2015-03-10       Impact factor: 4.030

2.  The dietary hydrolysable tannin punicalagin releases ellagic acid that induces apoptosis in human colon adenocarcinoma Caco-2 cells by using the mitochondrial pathway.

Authors:  Mar Larrosa; Francisco A Tomás-Barberán; Juan Carlos Espín
Journal:  J Nutr Biochem       Date:  2005-10-11       Impact factor: 6.048

Review 3.  Obesity and colorectal cancer.

Authors:  Marc Bardou; Alan N Barkun; Myriam Martel
Journal:  Gut       Date:  2013-03-12       Impact factor: 23.059

4.  Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012.

Authors:  J Ferlay; E Steliarova-Foucher; J Lortet-Tieulent; S Rosso; J W W Coebergh; H Comber; D Forman; F Bray
Journal:  Eur J Cancer       Date:  2013-02-26       Impact factor: 9.162

5.  Microarray analysis reveals that leptin induces autocrine/paracrine cascades to promote survival and proliferation of colon epithelial cells in an Apc genotype-dependent fashion.

Authors:  Jenifer I Fenton; Jackie A Lavigne; Susan N Perkins; Huaitian Liu; Gadisetti V R Chandramouli; Joanna H Shih; Norman G Hord; Stephen D Hursting
Journal:  Mol Carcinog       Date:  2008-01       Impact factor: 4.784

6.  Secreted human adipose leptin decreases mitochondrial respiration in HCT116 colon cancer cells.

Authors:  Einav Yehuda-Shnaidman; Lili Nimri; Tanya Tarnovscki; Boris Kirshtein; Assaf Rudich; Betty Schwartz
Journal:  PLoS One       Date:  2013-09-20       Impact factor: 3.240

7.  Differential crosstalk between the AMPK and PI3K/Akt pathways in breast cancer cells of differing genotypes: Leptin inhibits the effectiveness of AMPK activation.

Authors:  Omar S El-Masry; Kaltoom Al-Sakkaf; Barry L Brown; Pauline R M Dobson
Journal:  Oncol Rep       Date:  2015-08-11       Impact factor: 3.906

8.  Effects of ellagic Acid on angiogenic factors in prostate cancer cells.

Authors:  Luca Vanella; Claudia Di Giacomo; Rosaria Acquaviva; Ignazio Barbagallo; Giovanni Li Volti; Venera Cardile; Nader G Abraham; Valeria Sorrenti
Journal:  Cancers (Basel)       Date:  2013-06-19       Impact factor: 6.639

Review 9.  Research progress on the anticarcinogenic actions and mechanisms of ellagic acid.

Authors:  Hong-Mei Zhang; Lei Zhao; Hao Li; Hao Xu; Wen-Wen Chen; Lin Tao
Journal:  Cancer Biol Med       Date:  2014-06       Impact factor: 4.248

10.  Pomegranate vinegar attenuates adiposity in obese rats through coordinated control of AMPK signaling in the liver and adipose tissue.

Authors:  Elly Ok; Gyeong-Min Do; Yeni Lim; Ji-Eun Park; Yeo-Jin Park; Oran Kwon
Journal:  Lipids Health Dis       Date:  2013-11-02       Impact factor: 3.876
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  3 in total

Review 1.  Evidence for Anticancer Effects of Chinese Medicine Monomers on Colorectal Cancer.

Authors:  Tian-Hao Guo; Yuan-Yuan Li; Sheng-Wei Hong; Qian-Yu Cao; Heng Chen; Yuan Xu; Guo-Liang Dai; Gang Shao
Journal:  Chin J Integr Med       Date:  2022-04-13       Impact factor: 2.626

2.  The Nutritional Cytokine Leptin Promotes NSCLC by Activating the PI3K/AKT and MAPK/ERK Pathways in NSCLC Cells in a Paracrine Manner.

Authors:  Fengzhou Li; Shilei Zhao; Tao Guo; Jinxiu Li; Chundong Gu
Journal:  Biomed Res Int       Date:  2019-04-18       Impact factor: 3.411

3.  Simultaneous Hydrolysis of Ellagitannins and Extraction of Ellagic Acid from Defatted Raspberry Seeds Using Natural Deep Eutectic Solvents (NADES).

Authors:  Nemanja Teslić; Filipa Santos; Filipe Oliveira; Alena Stupar; Milica Pojić; Anamarija Mandić; Branimir Pavlić; Aleksandra Cvetanović Kljakić; Ana Rita C Duarte; Alexandre Paiva; Aleksandra Mišan
Journal:  Antioxidants (Basel)       Date:  2022-01-28
  3 in total

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