Literature DB >> 27459188

Influence of Protonation State on the Excited State Dynamics of a Photobiologically Active Ru(II) Dyad.

Christian Reichardt1,2, Tariq Sainuddin3, Maria Wächtler2, Susan Monro3, Stephan Kupfer1, Julien Guthmuller4, Stefanie Gräfe1, Sherri McFarland3,5, Benjamin Dietzek1,2.   

Abstract

The influence of ligand protonation on the photophysics of a ruthenium (Ru) dyad bearing the 2-(1-pyrenyl)-1H-imidazo[4,5-f][1,10]-phenanthroline (ippy) ligand was investigated by time-resolved transient absorption spectroscopy. It was found that changes in the protonation state of the imidazole group led to changes in the electronic configuration of the lowest lying excited state. Formation of the fully deprotonated imidazole anion resulted in excited state signatures that were consistent with a low-lying intraligand (IL) triplet state. This assignment was supported by time-dependent density functional theory (TDDFT) calculations. IL triplet states have been suggested to be potent mediators of photodynamic effects. Thus, these results are of interest in the design of Ru metal complexes as photosensitizers (PSs) for photodynamic therapy (PDT).

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Year:  2016        PMID： 27459188     DOI： 10.1021/acs.jpca.6b05957

Source DB:  PubMed          Journal:  J Phys Chem A        ISSN： 1089-5639            Impact factor:   2.781


  13 in total

1.  Predictive Strength of Photophysical Measurements for in Vitro Photobiological Activity in a Series of Ru(II) Polypyridyl Complexes Derived from π-Extended Ligands.

Authors:  Christian Reichardt; Susan Monro; Fabian H Sobotta; Katsuya L Colón; Tariq Sainuddin; Mat Stephenson; Eric Sampson; John Roque; Huimin Yin; Johannes C Brendel; Colin G Cameron; Sherri McFarland; Benjamin Dietzek
Journal:  Inorg Chem       Date:  2019-02-14       Impact factor: 5.165

2.  Synthesis, Characterization and Photobiological Studies of Ru(II) Dyads Derived from α-Oligothiophene Derivatives of 1,10-Phenanthroline.

Authors:  Susan Monro; Colin G Cameron; Xiaolin Zhu; Katsuya L Colón; Huimin Yin; Tariq Sainuddin; Marc Hetu; Mitch Pinto; Anderson Fuller; Leah Bennett; John Roque; Wenfang Sun; Sherri A McFarland
Journal:  Photochem Photobiol       Date:  2018-10-27       Impact factor: 3.421

3.  Photochemical and Photobiological Activity of Ru(II) Homoleptic and Heteroleptic Complexes Containing Methylated Bipyridyl-type Ligands.

Authors:  Lars Kohler; Leona Nease; Pascal Vo; Jenna Garofolo; David K Heidary; Randolph P Thummel; Edith C Glazer
Journal:  Inorg Chem       Date:  2017-09-26       Impact factor: 5.165

4.  Interaction with a Biomolecule Facilitates the Formation of the Function-Determining Long-Lived Triplet State in a Ruthenium Complex for Photodynamic Therapy.

Authors:  Avinash Chettri; Houston D Cole; John A Roque Iii; Kilian R A Schneider; Tingxiang Yang; Colin G Cameron; Sherri A McFarland; Benjamin Dietzek-Ivanšić
Journal:  J Phys Chem A       Date:  2022-02-18       Impact factor: 2.781

5.  Light-responsive and Protic Ruthenium Compounds Bearing Bathophenanthroline and Dihydroxybipyridine Ligands Achieve Nanomolar Toxicity towards Breast Cancer Cells.

Authors:  Olaitan E Oladipupo; Spenser R Brown; Robert W Lamb; Jessica L Gray; Colin G Cameron; Alexa R DeRegnaucourt; Nicholas A Ward; James Fletcher Hall; Yifei Xu; Courtney M Petersen; Fengrui Qu; Ambar B Shrestha; Matthew K Thompson; Marco Bonizzoni; Charles Edwin Webster; Sherri A McFarland; Yonghyun Kim; Elizabeth T Papish
Journal:  Photochem Photobiol       Date:  2021-11-13       Impact factor: 3.421

6.  Transition Metal Complexes and Photodynamic Therapy from a Tumor-Centered Approach: Challenges, Opportunities, and Highlights from the Development of TLD1433.

Authors:  Susan Monro; Katsuya L Colón; Huimin Yin; John Roque; Prathyusha Konda; Shashi Gujar; Randolph P Thummel; Lothar Lilge; Colin G Cameron; Sherri A McFarland
Journal:  Chem Rev       Date:  2018-10-08       Impact factor: 60.622

7.  CuAAC-based assembly and characterization of a ruthenium-copper dyad containing a diimine-dioxime ligand framework.

Authors:  Nicolas Queyriaux; Eugen S Andreiadis; Stéphane Torelli; Jacques Pecaut; Brad S Veldkamp; Eric A Margulies; Michael R Wasielewski; Murielle Chavarot-Kerlidou; Vincent Artero
Journal:  Faraday Discuss       Date:  2017-06-02       Impact factor: 4.008

8.  Bis[pyrrolyl Ru(ii)] triads: a new class of photosensitizers for metal-organic photodynamic therapy.

Authors:  Deborah A Smithen; Susan Monro; Mitch Pinto; John Roque; Roberto M Diaz-Rodriguez; Huimin Yin; Colin G Cameron; Alison Thompson; Sherri A McFarland
Journal:  Chem Sci       Date:  2020-10-06       Impact factor: 9.825

9.  Singlet Oxygen Formation vs Photodissociation for Light-Responsive Protic Ruthenium Anticancer Compounds: The Oxygenated Substituent Determines Which Pathway Dominates.

Authors:  Fengrui Qu; Robert W Lamb; Colin G Cameron; Seungjo Park; Olaitan Oladipupo; Jessica L Gray; Yifei Xu; Houston D Cole; Marco Bonizzoni; Yonghyun Kim; Sherri A McFarland; Charles Edwin Webster; Elizabeth T Papish
Journal:  Inorg Chem       Date:  2021-02-03       Impact factor: 5.165

10.  Merging of a Perylene Moiety Enables a RuII Photosensitizer with Long-Lived Excited States and the Efficient Production of Singlet Oxygen.

Authors:  Marie-Ann Schmid; Jannik Brückmann; Julian Bösking; Djawed Nauroozi; Michael Karnahl; Sven Rau; Stefanie Tschierlei
Journal:  Chemistry       Date:  2021-12-13       Impact factor: 5.020
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