L H Goldman1, K Tang2, L Facchetti3, U Heilmeier4, G B Joseph5, M C Nevitt6, C E McCulloch7, R B Souza8, T M Link9. 1. Department of Radiology and Biomedical Imaging, University of California, San Francisco, USA; Department of Radiology, Montefiore Medical Center, USA. Electronic address: lhackney@montefiore.org. 2. Department of Radiology and Biomedical Imaging, University of California, San Francisco, USA. Electronic address: kennethtangd1@yahoo.com. 3. Department of Radiology and Biomedical Imaging, University of California, San Francisco, USA; Department of Radiology, University of Brescia, Brescia, Italy. Electronic address: fachettil@gmail.com. 4. Department of Radiology and Biomedical Imaging, University of California, San Francisco, USA. Electronic address: ursula.heilmeier@ucsf.edu. 5. Department of Radiology and Biomedical Imaging, University of California, San Francisco, USA. Electronic address: gabby.joseph@ucsf.edu. 6. Department of Epidemiology and Biostatistics, University of California, San Francisco, USA. Electronic address: mnevitt@psg.ucsf.edu. 7. Department of Epidemiology and Biostatistics, University of California, San Francisco, USA. Electronic address: charles.mcculloch@ucsf.edu. 8. Department of Radiology and Biomedical Imaging, University of California, San Francisco, USA; Department of Physical Therapy and Rehabilitation Science, University of California, San Francisco, USA. Electronic address: richard.souza@ucsf.edu. 9. Department of Radiology and Biomedical Imaging, University of California, San Francisco, USA. Electronic address: thomas.link@ucsf.edu.
Abstract
OBJECTIVE: To determine in a 48-month longitudinal study the association of thigh muscle cross-sectional area (CSA) and strength on progression of morphologic knee cartilage degeneration using 3T magnetic resonance imaging (MRI). DESIGN: Seventy Osteoarthritis Initiative (OAI) subjects aged 50-60 years, with no radiographic evidence of osteoarthritis (OA) and constant muscle strength over 48 months as measured by isometric knee extension testing were included. Baseline right thigh muscle CSAs were assessed on axial T1-weighted magnetic resonance (MR) images, and extensor to flexor CSA ratios were calculated. Degenerative knee abnormalities at baseline and 48-months were graded on right knee 3T MRIs using a modified whole organ MRI score (WORMS). Statistical analysis employed Student's t-tests and multivariable regression models adjusted for age, body mass index and gender. RESULTS: Extension strength was significantly and positively correlated with baseline thigh muscle CSA (r = 0.65, P < 0.001). Greater baseline total thigh muscle CSA was significantly associated with increase of cartilage WORMS scores over 48 months in patellar (P = 0.027) and trochlear (P = 0.038) compartments, but not in other knee compartments. Among specific muscle groups, CSA of extensors (P = 0.021) and vastus medialis (VM) (P = 0.047) were associated with patellar cartilage increase in WORMS. Baseline E/F ratio had a significant positive association with patellar WORMS cartilage score increase over 48 months, P = 0.0015. There were no other significant associations between muscle CSA/ratios and increase in WORMS scores. CONCLUSION: Maintenance of proper extensor to flexor muscle balance about the knee through decreased E/F ratios may slow patellofemoral cartilage deterioration, while higher extensor and VM CSA may increase patellofemoral cartilage loss.
OBJECTIVE: To determine in a 48-month longitudinal study the association of thigh muscle cross-sectional area (CSA) and strength on progression of morphologic knee cartilage degeneration using 3T magnetic resonance imaging (MRI). DESIGN: Seventy Osteoarthritis Initiative (OAI) subjects aged 50-60 years, with no radiographic evidence of osteoarthritis (OA) and constant muscle strength over 48 months as measured by isometric knee extension testing were included. Baseline right thigh muscle CSAs were assessed on axial T1-weighted magnetic resonance (MR) images, and extensor to flexor CSA ratios were calculated. Degenerative knee abnormalities at baseline and 48-months were graded on right knee 3T MRIs using a modified whole organ MRI score (WORMS). Statistical analysis employed Student's t-tests and multivariable regression models adjusted for age, body mass index and gender. RESULTS: Extension strength was significantly and positively correlated with baseline thigh muscle CSA (r = 0.65, P < 0.001). Greater baseline total thigh muscle CSA was significantly associated with increase of cartilage WORMS scores over 48 months in patellar (P = 0.027) and trochlear (P = 0.038) compartments, but not in other knee compartments. Among specific muscle groups, CSA of extensors (P = 0.021) and vastus medialis (VM) (P = 0.047) were associated with patellar cartilage increase in WORMS. Baseline E/F ratio had a significant positive association with patellar WORMS cartilage score increase over 48 months, P = 0.0015. There were no other significant associations between muscle CSA/ratios and increase in WORMS scores. CONCLUSION: Maintenance of proper extensor to flexor muscle balance about the knee through decreased E/F ratios may slow patellofemoral cartilage deterioration, while higher extensor and VM CSA may increase patellofemoral cartilage loss.
Authors: N A Segal; N A Glass; J Torner; M Yang; D T Felson; L Sharma; M Nevitt; C E Lewis Journal: Osteoarthritis Cartilage Date: 2010-02-11 Impact factor: 6.576
Authors: Belle L van Meer; Duncan E Meuffels; Wilbert A van Eijsden; Jan A N Verhaar; Sita M A Bierma-Zeinstra; Max Reijman Journal: Br J Sports Med Date: 2015-03-30 Impact factor: 13.800
Authors: A S Ruhdorfer; T Dannhauer; W Wirth; S Cotofana; F Roemer; M Nevitt; F Eckstein Journal: Osteoarthritis Cartilage Date: 2014-10 Impact factor: 6.576
Authors: Merja H Arokoski; Jari P A Arokoski; Mikko Haara; Markku Kankaanpää; Minna Vesterinen; Lea H Niemitukia; Heikki J Helminen Journal: J Rheumatol Date: 2002-10 Impact factor: 4.666
Authors: Christoph Stehling; Hans Liebl; Roland Krug; Nancy E Lane; Michael C Nevitt; John Lynch; Charles E McCulloch; Thomas M Link Journal: Radiology Date: 2009-12-17 Impact factor: 11.105
Authors: N A Glass; J C Torner; L A Frey Law; K Wang; T Yang; M C Nevitt; D T Felson; C E Lewis; N A Segal Journal: Osteoarthritis Cartilage Date: 2013-09 Impact factor: 6.576
Authors: Josien C van den Noort; Marike van der Leeden; Gerard Stapper; Wolfgang Wirth; Mario Maas; Leo D Roorda; Willem F Lems; Joost Dekker; Martin van der Esch Journal: BMC Musculoskelet Disord Date: 2022-01-27 Impact factor: 2.362