Literature DB >> 2745561

TGF-beta stimulates primary human skin fibroblast DNA synthesis via an autocrine production of PDGF-related peptides.

Y Soma1, G R Grotendorst.   

Abstract

Transforming growth factor-beta (TGF-beta) stimulates DNA synthesis in human foreskin fibroblasts after a prolonged lag period as compared with other growth factors. The mechanism of induction of DNA synthesis appears to be dependent on the synthesis and secretion of PDGF-related proteins as antibodies which are specific for PDGF can block the TGF-beta-induced DNA synthesis. Other growth factors such as PDGF, EGF, or FGF do not induce the synthesis of these PDGF-related proteins. Additionally, TGF-beta treatment of human foreskin fibroblasts induces the expression of the PDGF A-chain gene but not the B-chain gene. This phenomenon appears to function in vivo, as subcutaneous injection of TGF-beta in rat skin induces the expression of the PDGF A-chain gene. These data suggest that TGF-beta may stimulate the growth of fibroblastic cells via an autocrine production of PDGF-related proteins.

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Year:  1989        PMID： 2745561     DOI： 10.1002/jcp.1041400209

Source DB:  PubMed          Journal:  J Cell Physiol        ISSN： 0021-9541            Impact factor:   6.384


  29 in total

1.  The effects of scleroderma sera on endothelial cell survival in vitro.

Authors:  T Etoh; A Igarashi; K Iozumi; Y Ishibashi; K Takehara
Journal:  Arch Dermatol Res       Date:  1990       Impact factor: 3.017

2.  Stimulation of endothelin mRNA and secretion in rat vascular smooth muscle cells: a novel autocrine function.

Authors:  A W Hahn; T J Resink; T Scott-Burden; J Powell; Y Dohi; F R Bühler
Journal:  Cell Regul       Date:  1990-08

3.  Response of scleroderma fibroblasts to various growth factors.

Authors:  K Takehara; Y Soma; A Igarashi; K Kikuchi; A Moro; Y Ishibashi
Journal:  Arch Dermatol Res       Date:  1991       Impact factor: 3.017

4.  Transforming growth factor beta as a potential tumor progression factor among hyperdiploid glioblastoma cultures: evidence for the role of platelet-derived growth factor.

Authors:  M T Jennings; C E Hart; P A Commers; J A Whitlock; D Martincic; R J Maciunas; P L Moots; T M Shehab
Journal:  J Neurooncol       Date:  1997-02       Impact factor: 4.130

5.  Specific growth stimulation of cultured smooth muscle cells from spontaneously hypertensive rats by platelet-derived growth factor A-chain homodimer.

Authors:  T J Resink; T Scott-Burden; A W Hahn; M Rouge; M Hosang; J S Powell; F R Bühler
Journal:  Cell Regul       Date:  1990-10

6.  Indomethacin suppresses the anti-proliferative effects of transforming growth factor-beta isoforms on fibroblast cell cultures.

Authors:  R J McAnulty; N A Hernández-Rodriguez; S E Mutsaers; R K Coker; G J Laurent
Journal:  Biochem J       Date:  1997-02-01       Impact factor: 3.857

7.  Titration of non-replicating adenovirus as a vector for transducing active TGF-beta1 gene expression causing inflammation and fibrogenesis in the lungs of C57BL/6 mice.

Authors:  G Sakuntala Warshamana; Derek A Pociask; Krishna J Fisher; Jing-Yao Liu; Patricia J Sime; Arnold R Brody
Journal:  Int J Exp Pathol       Date:  2002-08       Impact factor: 1.925

8.  Inhibition of skin development by overexpression of transforming growth factor beta 1 in the epidermis of transgenic mice.

Authors:  K Sellheyer; J R Bickenbach; J A Rothnagel; D Bundman; M A Longley; T Krieg; N S Roche; A B Roberts; D R Roop
Journal:  Proc Natl Acad Sci U S A       Date:  1993-06-01       Impact factor: 11.205

9.  Okadaic acid regulation of the retinoblastoma gene product is correlated with the inhibition of growth factor-induced cell proliferation in mouse fibroblasts.

Authors:  T A Kim; B R Velasquez; C E Wenner
Journal:  Proc Natl Acad Sci U S A       Date:  1993-06-15       Impact factor: 11.205

10.  Transforming growth factor beta stimulates urokinase-type plasminogen activator and DNA synthesis, but not prostaglandin E2 production, in human synovial fibroblasts.

Authors:  J A Hamilton; D S Piccoli; T Leizer; D M Butler; M Croatto; A K Royston
Journal:  Proc Natl Acad Sci U S A       Date:  1991-08-15       Impact factor: 11.205
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