Literature DB >> 27455458

Extended surface for membrane association in Zika virus NS1 structure.

W Clay Brown1, David L Akey1, Jamie R Konwerski1, Jeffrey T Tarrasch1, Georgios Skiniotis1,2, Richard J Kuhn3,4, Janet L Smith1,2.   

Abstract

The Zika virus, which has been implicated in an increase in neonatal microcephaly and Guillain-Barré syndrome, has spread rapidly through tropical regions of the world. The virulence protein NS1 functions in genome replication and host immune-system modulation. Here, we report the crystal structure of full-length Zika virus NS1, revealing an elongated hydrophobic surface for membrane association and a polar surface that varies substantially among flaviviruses.

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Year:  2016        PMID： 27455458      PMCID： PMC5951387          DOI： 10.1038/nsmb.3268

Source DB:  PubMed          Journal:  Nat Struct Mol Biol        ISSN： 1545-9985            Impact factor:   15.369


  28 in total

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2.  Zika virus. I. Isolations and serological specificity.

Authors:  G W A DICK; S F KITCHEN; A J HADDOW
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3.  Structure of the dengue virus glycoprotein non-structural protein 1 by electron microscopy and single-particle analysis.

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5.  Structural basis of Flavivirus NS1 assembly and antibody recognition.

Authors:  Melissa A Edeling; Michael S Diamond; Daved H Fremont
Journal:  Proc Natl Acad Sci U S A       Date:  2014-03-04       Impact factor: 11.205

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Journal:  Antiviral Res       Date:  2016-03-02       Impact factor: 5.970

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8.  Guillain-Barré Syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study.

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  50 in total

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2.  Emulsion Agglutination Assay for the Detection of Protein-Protein Interactions: An Optical Sensor for Zika Virus.

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6.  Comprehensive Evaluation of Differential Serodiagnosis between Zika and Dengue Viral Infections.

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Review 7.  Small Molecules and Antibodies for Zika Therapy.

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8.  Transposon Mutagenesis of the Zika Virus Genome Highlights Regions Essential for RNA Replication and Restricted for Immune Evasion.

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Review 9.  Secretion of Nonstructural Protein 1 of Dengue Virus from Infected Mosquito Cells: Facts and Speculations.

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Review 10.  ER functions are exploited by viruses to support distinct stages of their life cycle.

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