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Literature DB >> 27453773

Effect of intercalator and Lewis acid-base branched peptide complex formation: boosting affinity towards HIV-1 RRE RNA.

Jessica E Wynn¹, Wenyu Zhang¹, Denis M Tebit², Laurie R Gray², Marie-Louise Hammarskjold², David Rekosh², Webster L Santos¹.

Abstract

High throughput screening of a 4096 compound library of boronic acid and acridine containing branched peptides revealed compounds that have dissociation constants in the low nanomolar regime for HIV-1 RRE IIB RNA. We demonstrate that branched peptide boronic acids A5, A6, and A7 inhibit the production of p24, an HIV-1 capsid protein, in a dose-dependent manner.

Entities: CellLine Chemical Disease Gene Species

Year: 2016 PMID： 27453773 PMCID： PMC4957400 DOI： 10.1039/C6MD00171H

Source DB: PubMed Journal: Medchemcomm ISSN： 2040-2503 Impact factor: 3.597

28 in total

1. Toward targeting RNA structure: branched peptides as cell-permeable ligands to TAR RNA.

Authors: David I Bryson; Wenyu Zhang; Patrick M McLendon; Theresa M Reineke; Webster L Santos
Journal: ACS Chem Biol Date: 2011-10-28 Impact factor: 5.100

2. New inhibitors of the Tat-TAR RNA interaction found with a "fuzzy" pharmacophore model.

Authors: Steffen Renner; Verena Ludwig; Oliver Boden; Ute Scheffer; Michael Göbel; Gisbert Schneider
Journal: Chembiochem Date: 2005-06 Impact factor: 3.164

3. Amphiphilic helical peptides containing two acridine moieties display picomolar affinity toward HIV-1 RRE and TAR.

Authors: Yeongran Lee; Soonsil Hyun; Hyun Jin Kim; Jaehoon Yu
Journal: Angew Chem Int Ed Engl Date: 2008 Impact factor: 15.336

4. Structural analysis of the interaction between the human immunodeficiency virus Rev protein and the Rev response element.

Authors: J Kjems; M Brown; D D Chang; P A Sharp
Journal: Proc Natl Acad Sci U S A Date: 1991-02-01 Impact factor: 11.205

Review 5. The HIV-1 Rev protein.

Authors: V W Pollard; M H Malim
Journal: Annu Rev Microbiol Date: 1998 Impact factor: 15.500

6. Real-time kinetics of HIV-1 Rev-Rev response element interactions. Definition of minimal binding sites on RNA and protein and stoichiometric analysis.

Authors: D I Van Ryk; S Venkatesan
Journal: J Biol Chem Date: 1999-06-18 Impact factor: 5.157

7. Branched peptide boronic acids (BPBAs): a novel mode of binding towards RNA.

Authors: Wenyu Zhang; David I Bryson; Jason B Crumpton; Jessica Wynn; Webster L Santos
Journal: Chem Commun (Camb) Date: 2013-03-25 Impact factor: 6.222

8. Divergent evolution in reverse transcriptase (RT) of HIV-1 group O and M lineages: impact on structure, fitness, and sensitivity to nonnucleoside RT inhibitors.

Authors: Denis M Tebit; Michael Lobritz; Matthew Lalonde; Taina Immonen; Kamlendra Singh; Stefanos Sarafianos; Ottmar Herchenröder; Hans-Georg Kräusslich; Eric J Arts
Journal: J Virol Date: 2010-07-14 Impact factor: 5.103

9. RNA-ligand interactions: affinity and specificity of aminoglycoside dimers and acridine conjugates to the HIV-1 Rev response element.

Authors: Nathan W Luedtke; Qi Liu; Yitzhak Tor
Journal: Biochemistry Date: 2003-10-07 Impact factor: 3.162

Effect of intercalator and Lewis acid-base branched peptide complex formation: boosting affinity towards HIV-1 RRE RNA.

1. Toward targeting RNA structure: branched peptides as cell-permeable ligands to TAR RNA.

2. New inhibitors of the Tat-TAR RNA interaction found with a "fuzzy" pharmacophore model.

3. Amphiphilic helical peptides containing two acridine moieties display picomolar affinity toward HIV-1 RRE and TAR.

4. Structural analysis of the interaction between the human immunodeficiency virus Rev protein and the Rev response element.

Review 5. The HIV-1 Rev protein.

6. Real-time kinetics of HIV-1 Rev-Rev response element interactions. Definition of minimal binding sites on RNA and protein and stoichiometric analysis.

7. Branched peptide boronic acids (BPBAs): a novel mode of binding towards RNA.

8. Divergent evolution in reverse transcriptase (RT) of HIV-1 group O and M lineages: impact on structure, fitness, and sensitivity to nonnucleoside RT inhibitors.

9. RNA-ligand interactions: affinity and specificity of aminoglycoside dimers and acridine conjugates to the HIV-1 Rev response element.

10. Heterocyclic compounds that inhibit Rev-RRE function and human immunodeficiency virus type 1 replication.

1. Molecular recognition of HIV-1 RNAs with branched peptides.

2. Branched Peptides: Acridine and Boronic Acid Derivatives as Antimicrobial Agents.

3. Molecular recognition of a branched peptide with HIV-1 Rev Response Element (RRE) RNA.

4. Discovery of a Branched Peptide That Recognizes the Rev Response Element (RRE) RNA and Blocks HIV-1 Replication.