Alberto Alonso-Fernández1, Angela García Suquia2, Mónica de la Peña3, Raquel Casitas4, Javier Pierola5, Antonia Barceló6, Joan B Soriano7, Carmen Fernández-Capitán8, Elizabet Martinez-Ceron4, Miguel Carrera3, Francisco García-Río4. 1. Department of Pneumology, University Hospital Son Espases, Palma de Mallorca, Spain; CIBER Enfermedades Respiratorias, Palma de Mallorca, Illes Balears, Spain. Electronic address: alberto.alonso@ssib.es. 2. Department of Clinical Analysis, University Hospital Son Espases, Palma de Mallorca, Spain. 3. Department of Pneumology, University Hospital Son Espases, Palma de Mallorca, Spain; CIBER Enfermedades Respiratorias, Palma de Mallorca, Illes Balears, Spain. 4. Department of Pneumology, University Hospital La Paz, IdiPAZ, Madrid, Spain; CIBER Enfermedades Respiratorias, Palma de Mallorca, Illes Balears, Spain. 5. Research Unit, University Hospital Son Espases, Palma de Mallorca, (IdISPa) Spain; CIBER Enfermedades Respiratorias, Palma de Mallorca, Illes Balears, Spain. 6. Department of Clinical Analysis, University Hospital Son Espases, Palma de Mallorca, Spain; CIBER Enfermedades Respiratorias, Palma de Mallorca, Illes Balears, Spain. 7. Instituto de Investigación Hospital Universitario de la Princesa (IISP), Universidad Autónoma de Madrid, Cátedra UAM-Linde, Madrid, Spain. 8. Department of Internal Medicine, University Hospital La Paz, Madrid, Spain.
Abstract
BACKGROUND: OSA is a risk factor for a first episode of pulmonary embolism (PE), although its impact on the risk of thromboembolism recurring is uncertain. Our objective was to explore the prognostic value of OSA after the discontinuation of oral anticoagulation (OAC) in patients with a first episode of PE. METHODS: In 120 consecutive patients who had stopped OAC for a first episode of PE, we performed home respiratory polygraphy and recorded sleep characteristics, classic risk factors for PE, blood pressure measurements, spirometric parameters, physical activity, and levels of D-dimer and prothrombin fragment 1+2 (F1+2). Patients were followed for 5 to 8 years, and the main end point was PE recurrence. Restarting OAC for any thromboembolic event was evaluated as a secondary end point. RESULTS: During the follow-up period, 19 patients had a PE recurrence, and 16 of them had an apnea-hypopnea index (AHI) ≥ 10 h-1. In a multivariate Cox regression model, an AHI ≥ 10 h-1 (hazard ratio [HR], 20.73; 95% CI, 1.71-251.28), mean nocturnal oxygen saturation (nSao2) (HR, 0.39; 95% CI, 0.20-0.78), time with Sao2 < 90% (CT90%) (HR, 0.90; 95% CI, 0.82-0.98), and D-dimer level (HR, 1.001; 95% CI, 1.00-1.002) were identified as independent risk factors for recurrent PE. Twenty-four patients resumed OAC, and AHI ≥ 10 h-1 (HR, 20.66; 95% CI, 2.27-188.35), mean nSao2 (HR, 0.54; 95% CI, 0.32-0.94), and Epworth Sleepiness Scale (ESS) (HR, 0.73; 95% CI, 0.56-0.97) were retained as independent risk factors for the resumption of OAC. CONCLUSIONS: After a first episode of PE, OSA is an independent risk factor for PE recurrence or restarting OAC for a new thromboembolic event. Copyright Â
BACKGROUND: OSA is a risk factor for a first episode of pulmonary embolism (PE), although its impact on the risk of thromboembolism recurring is uncertain. Our objective was to explore the prognostic value of OSA after the discontinuation of oral anticoagulation (OAC) in patients with a first episode of PE. METHODS: In 120 consecutive patients who had stopped OAC for a first episode of PE, we performed home respiratory polygraphy and recorded sleep characteristics, classic risk factors for PE, blood pressure measurements, spirometric parameters, physical activity, and levels of D-dimer and prothrombin fragment 1+2 (F1+2). Patients were followed for 5 to 8 years, and the main end point was PE recurrence. Restarting OAC for any thromboembolic event was evaluated as a secondary end point. RESULTS: During the follow-up period, 19 patients had a PE recurrence, and 16 of them had an apnea-hypopnea index (AHI) ≥ 10 h-1. In a multivariate Cox regression model, an AHI ≥ 10 h-1 (hazard ratio [HR], 20.73; 95% CI, 1.71-251.28), mean nocturnal oxygen saturation (nSao2) (HR, 0.39; 95% CI, 0.20-0.78), time with Sao2 < 90% (CT90%) (HR, 0.90; 95% CI, 0.82-0.98), and D-dimer level (HR, 1.001; 95% CI, 1.00-1.002) were identified as independent risk factors for recurrent PE. Twenty-four patients resumed OAC, and AHI ≥ 10 h-1 (HR, 20.66; 95% CI, 2.27-188.35), mean nSao2 (HR, 0.54; 95% CI, 0.32-0.94), and Epworth Sleepiness Scale (ESS) (HR, 0.73; 95% CI, 0.56-0.97) were retained as independent risk factors for the resumption of OAC. CONCLUSIONS: After a first episode of PE, OSA is an independent risk factor for PE recurrence or restarting OAC for a new thromboembolic event. Copyright Â
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