Christopher N Kaufmann1, Anda Gershon2, Lisa T Eyler3, Colin A Depp3. 1. Department of Psychiatry, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA; Stein Institute for Research on Aging, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA. Electronic address: cnkaufmann@ucsd.edu. 2. Child and Adolescent Psychiatry, Psychiatry and Behavioral Sciences, Stanford University, 401 Quarry Road, Palo Alto, CA, 94305, USA. 3. Department of Psychiatry, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA; Stein Institute for Research on Aging, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
Abstract
OBJECTIVE: Sleep disturbances are prevalent, persistent, and impairing features of bipolar disorder. However, the near-term and cumulative impact of the severity and variability of sleep disturbances on symptoms and functioning remains unclear. We examined self-reported daily sleep duration and variability in relation to mood symptoms, medication adherence, cognitive functioning, and concurrent daily affect. METHODS: Forty-one outpatients diagnosed with bipolar disorder were asked to provide daily reports of sleep duration and affect collected via ecological momentary assessment with smartphones over eleven weeks. Measures of depressive and manic symptoms, medication adherence, and cognitive function were collected at baseline and concurrent assessment of affect were collected daily. Analyses examined whether sleep duration or variability were associated with baseline measures and changes in same-day or next-day affect. RESULTS: Greater sleep duration variability (but not average sleep duration) was associated with greater depressive and manic symptom severity, and lower medication adherence at baseline, and with lower and more variable ratings of positive affect and higher ratings of negative affect. Sleep durations shorter than 7-8 h were associated with lower same-day ratings of positive and higher same-day ratings of negative affect, however this did not extend to next-day affect. CONCLUSIONS: Greater cumulative day-to-day sleep duration variability, but not average sleep duration, was related to more severe mood symptoms, lower self-reported medication adherence and higher levels of negative affect. Bouts of short- or long-duration sleep had transient impact on affect. Day-to-day sleep variability may be important to incorporate into clinical assessment of sleep disturbances in bipolar disorder.
OBJECTIVE:Sleep disturbances are prevalent, persistent, and impairing features of bipolar disorder. However, the near-term and cumulative impact of the severity and variability of sleep disturbances on symptoms and functioning remains unclear. We examined self-reported daily sleep duration and variability in relation to mood symptoms, medication adherence, cognitive functioning, and concurrent daily affect. METHODS: Forty-one outpatients diagnosed with bipolar disorder were asked to provide daily reports of sleep duration and affect collected via ecological momentary assessment with smartphones over eleven weeks. Measures of depressive and manic symptoms, medication adherence, and cognitive function were collected at baseline and concurrent assessment of affect were collected daily. Analyses examined whether sleep duration or variability were associated with baseline measures and changes in same-day or next-day affect. RESULTS: Greater sleep duration variability (but not average sleep duration) was associated with greater depressive and manic symptom severity, and lower medication adherence at baseline, and with lower and more variable ratings of positive affect and higher ratings of negative affect. Sleep durations shorter than 7-8 h were associated with lower same-day ratings of positive and higher same-day ratings of negative affect, however this did not extend to next-day affect. CONCLUSIONS: Greater cumulative day-to-day sleep duration variability, but not average sleep duration, was related to more severe mood symptoms, lower self-reported medication adherence and higher levels of negative affect. Bouts of short- or long-duration sleep had transient impact on affect. Day-to-day sleep variability may be important to incorporate into clinical assessment of sleep disturbances in bipolar disorder.
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Authors: Adriane M Soehner; Tina R Goldstein; Sarah M Gratzmiller; Mary L Phillips; Peter L Franzen Journal: Bipolar Disord Date: 2018-02-13 Impact factor: 6.744
Authors: Christopher N Kaufmann; Anda Gershon; Colin A Depp; Shefali Miller; Jamie M Zeitzer; Terence A Ketter Journal: J Affect Disord Date: 2018-08-10 Impact factor: 4.839
Authors: Molly Patapoff; Marina Ramsey; Madison Titone; Christopher N Kaufmann; Atul Malhotra; Sonia Ancoli-Israel; David Wing; Ellen Lee; Lisa T Eyler Journal: J Psychiatr Res Date: 2022-04-03 Impact factor: 5.250
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Authors: Ellen Lee; Marina Ramsey; Atul Malhotra; Sonia Ancoli-Israel; Christopher N Kaufmann; Benchawanna Soontornniyomkij; Sarah A Graham; Colin Depp; Lisa T Eyler Journal: J Psychiatr Res Date: 2020-12-13 Impact factor: 4.791
Authors: Christopher N Kaufmann; Ellen E Lee; David Wing; Ashley N Sutherland; Celestine Christensen; Sonia Ancoli-Israel; Colin A Depp; Ho-Kyoung Yoon; Benchawanna Soontornniyomkij; Lisa T Eyler Journal: J Psychiatr Res Date: 2021-06-21 Impact factor: 5.250
Authors: Tilman Hensch; David Wozniak; Janek Spada; Christian Sander; Christine Ulke; Dirk Alexander Wittekind; Joachim Thiery; Markus Löffler; Philippe Jawinski; Ulrich Hegerl Journal: Transl Psychiatry Date: 2019-11-11 Impact factor: 6.222
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