Literature DB >> 27448303

Molecular targets of gambogic acid in cancer: recent trends and advancements.

Dharambir Kashyap1, Rajkumar Mondal2, Hardeep Singh Tuli3, Gaurav Kumar4, Anil K Sharma2.   

Abstract

Natural compounds have been known as biosafety agents for their significant clinical and biological activity against dreadful diseases, including cancer, cardiovascular, and neurodegenerative disorders. Gambogic acid (GA), a naturally occurring xanthone-based moiety, reported from Garcinia hanburyi tree, is known to perform numerous intracellular and extracellular actions, including programmed cell death, autophagy, cell cycle arrest, antiangiogenesis, antimetastatic, and anti-inflammatory activities. In addition, GA-based synergistic approaches have been proven to enhance the healing strength of existing chemotherapeutic agents along with lesser side effects. The present review uncovers the bio-therapeutic potential of gambogic acid along with the possible mechanistic interactions of GA with its recognized cellular targets.

Entities:  

Keywords:  Anti-inflammatory; Antiangiogenesis; Antimetastasis; Apoptosis; Autophagy; Gambogic acid; Synergistic effect

Mesh：

Substances：

Year:  2016        PMID： 27448303     DOI： 10.1007/s13277-016-5194-8

Source DB:  PubMed          Journal:  Tumour Biol        ISSN： 1010-4283


  100 in total

1.  Gambogic acid inhibits Hsp90 and deregulates TNF-α/NF-κB in HeLa cells.

Authors:  Lianru Zhang; Yuting Yi; Junjie Chen; Yifei Sun; Qiuju Guo; Zhonghui Zheng; Siyang Song
Journal:  Biochem Biophys Res Commun       Date:  2010-11-11       Impact factor: 3.575

2.  Gambogic acid inhibits STAT3 phosphorylation through activation of protein tyrosine phosphatase SHP-1: potential role in proliferation and apoptosis.

Authors:  Sahdeo Prasad; Manoj K Pandey; Vivek R Yadav; Bharat B Aggarwal
Journal:  Cancer Prev Res (Phila)       Date:  2011-04-13

Review 3.  Targeting the protein kinase C family: are we there yet?

Authors:  Helen J Mackay; Christopher J Twelves
Journal:  Nat Rev Cancer       Date:  2007-07       Impact factor: 60.716

Review 4.  Autophagy at the crossroads of catabolism and anabolism.

Authors:  Jasvinder Kaur; Jayanta Debnath
Journal:  Nat Rev Mol Cell Biol       Date:  2015-07-15       Impact factor: 94.444

5.  Gambogic acid induces apoptosis in imatinib-resistant chronic myeloid leukemia cells via inducing proteasome inhibition and caspase-dependent Bcr-Abl downregulation.

Authors:  Xianping Shi; Xin Chen; Xiaofen Li; Xiaoying Lan; Chong Zhao; Shouting Liu; Hongbiao Huang; Ningning Liu; Siyan Liao; Wenbin Song; Ping Zhou; Shunqing Wang; Li Xu; Xuejun Wang; Q Ping Dou; Jinbao Liu
Journal:  Clin Cancer Res       Date:  2013-12-12       Impact factor: 12.531

6.  Studies on chemical structure modification and biology of a natural product, gambogic acid (I): Synthesis and biological evaluation of oxidized analogues of gambogic acid.

Authors:  Jinxin Wang; Li Zhao; Yang Hu; Qinglong Guo; Lei Zhang; Xiaojian Wang; Nianguang Li; Qidong You
Journal:  Eur J Med Chem       Date:  2008-10-07       Impact factor: 6.514

7.  Microtubule depolymerization and phosphorylation of c-Jun N-terminal kinase-1 and p38 were involved in gambogic acid induced cell cycle arrest and apoptosis in human breast carcinoma MCF-7 cells.

Authors:  Jing Chen; Hong-Yan Gu; Na Lu; Yong Yang; Wei Liu; Qi Qi; Jing-Jing Rong; Xiao-Tang Wang; Qi-Dong You; Qing-Long Guo
Journal:  Life Sci       Date:  2008-05-16       Impact factor: 5.037

8.  Gambogic acid inhibits multiple myeloma mediated osteoclastogenesis through suppression of chemokine receptor CXCR4 signaling pathways.

Authors:  Manoj K Pandey; Vijay P Kale; Chunhua Song; Shen-shu Sung; Arun K Sharma; Giampaolo Talamo; Sinisa Dovat; Shantu G Amin
Journal:  Exp Hematol       Date:  2014-07-14       Impact factor: 3.084

Review 9.  Ursolic acid (UA): A metabolite with promising therapeutic potential.

Authors:  Dharambir Kashyap; Hardeep Singh Tuli; Anil K Sharma
Journal:  Life Sci       Date:  2016-01-14       Impact factor: 5.037

Review 10.  Molecular aspects of metal oxide nanoparticle (MO-NPs) mediated pharmacological effects.

Authors:  Hardeep Singh Tuli; Dharambir Kashyap; Simranjeet Kaur Bedi; Pardeep Kumar; Gaurav Kumar; Sardul Singh Sandhu
Journal:  Life Sci       Date:  2015-10-23       Impact factor: 5.037
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  18 in total

Review 1.  Gambogic acid: A shining natural compound to nanomedicine for cancer therapeutics.

Authors:  Elham Hatami; Meena Jaggi; Subhash C Chauhan; Murali M Yallapu
Journal:  Biochim Biophys Acta Rev Cancer       Date:  2020-05-31       Impact factor: 10.680

2.  The growth inhibitory effect of gambogic acid on pancreatic cancer cells.

Authors:  Mаhmoud Youns; Abeer ElKhoely; Rehab Kamel
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2018-03-15       Impact factor: 3.000

Review 3.  Oncogenic and Tumor-Suppressive Roles of MicroRNAs with Special Reference to Apoptosis: Molecular Mechanisms and Therapeutic Potential.

Authors:  Dharambir Kashyap; Hardeep Singh Tuli; Vivek Kumar Garg; Neelam Goel; Anupam Bishayee
Journal:  Mol Diagn Ther       Date:  2018-04       Impact factor: 4.074

4.  Gambogic acid potentiates gemcitabine induced anticancer activity in non-small cell lung cancer.

Authors:  Elham Hatami; Prashanth K B Nagesh; Meena Jaggi; Subhash C Chauhan; Murali M Yallapu
Journal:  Eur J Pharmacol       Date:  2020-08-14       Impact factor: 4.432

5.  Gambogic acid sensitizes gemcitabine efficacy in pancreatic cancer by reducing the expression of ribonucleotide reductase subunit-M2 (RRM2).

Authors:  Guanggai Xia; Hongcheng Wang; Ziliang Song; Qingcai Meng; Xiuyan Huang; Xinyu Huang
Journal:  J Exp Clin Cancer Res       Date:  2017-08-10

Review 6.  Fisetin and Quercetin: Promising Flavonoids with Chemopreventive Potential.

Authors:  Dharambir Kashyap; Vivek Kumar Garg; Hardeep Singh Tuli; Mukerrem Betul Yerer; Katrin Sak; Anil Kumar Sharma; Manoj Kumar; Vaishali Aggarwal; Sardul Singh Sandhu
Journal:  Biomolecules       Date:  2019-05-06

Review 7.  Molecular Mechanisms of Action of Tocotrienols in Cancer: Recent Trends and Advancements.

Authors:  Vaishali Aggarwal; Dharambir Kashyap; Katrin Sak; Hardeep Singh Tuli; Aklank Jain; Ashun Chaudhary; Vivek Kumar Garg; Gautam Sethi; Mukerrem Betul Yerer
Journal:  Int J Mol Sci       Date:  2019-02-02       Impact factor: 5.923

8.  Gambogic acid induces autophagy and combines synergistically with chloroquine to suppress pancreatic cancer by increasing the accumulation of reactive oxygen species.

Authors:  Hongcheng Wang; Zhi Zhao; Shizhou Lei; Shaoli Li; Zhen Xiang; Xiaoyu Wang; Xiuyan Huang; Guanggai Xia; Xinyu Huang
Journal:  Cancer Cell Int       Date:  2019-01-05       Impact factor: 5.722

9.  Gambogic acid inhibits thioredoxin activity and induces ROS-mediated cell death in castration-resistant prostate cancer.

Authors:  Hong Pan; Keith H Jansson; Michael L Beshiri; JuanJuan Yin; Lei Fang; Supreet Agarwal; Holly Nguyen; Eva Corey; Ying Zhang; Jie Liu; HuiTing Fan; HongSheng Lin; Kathleen Kelly
Journal:  Oncotarget       Date:  2017-08-24

10.  Gambogic acid regulates the migration and invasion of colorectal cancer via microRNA-21-mediated activation of phosphatase and tensin homolog.

Authors:  Guangyi Gao; Yinzhu Bian; Hanqing Qian; Mi Yang; Jing Hu; Li Li; Lixia Yu; Baorui Liu; Xiaoping Qian
Journal:  Exp Ther Med       Date:  2018-07-06       Impact factor: 2.447
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