Literature DB >> 26775565

Ursolic acid (UA): A metabolite with promising therapeutic potential.

Dharambir Kashyap1, Hardeep Singh Tuli2, Anil K Sharma3.   

Abstract

Plants are known to produce a variety of bioactive metabolites which are being used to cure various life threatening and chronic diseases. The molecular mechanism of action of such bioactive molecules, may open up new avenues for the scientific community to develop or improve novel therapeutic approaches to tackle dreadful diseases such as cancer and cardiovascular and neurodegenerative disorders. Ursolic acid (UA) is one among the categories of such plant-based therapeutic metabolites having multiple intracellular and extracellular targets that play role in apoptosis, metastasis, angiogenesis and inflammatory processes. Moreover, the synthetic derivatives of UA have also been seen to be involved in a range of pharmacological applications, which are associated with prevention of diseases. Evidences suggest that UA could be used as a potential candidate to develop a comprehensive competent strategy towards the treatment and prevention of health disorders. The review article herein describes the possible therapeutic effects of UA along with putative mechanism of action.
Copyright © 2016 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Anti-inflammatory; Anti-metastasis; Anti-oxidant; Apoptosis; Derivatives; Ursolic acid

Mesh:

Substances:

Year:  2016        PMID: 26775565     DOI: 10.1016/j.lfs.2016.01.017

Source DB:  PubMed          Journal:  Life Sci        ISSN: 0024-3205            Impact factor:   5.037


  60 in total

1.  Ursolic acid isolated from Isodon excisoides induces apoptosis and inhibits invasion of GBC-SD gallbladder carcinoma cells.

Authors:  Huiping Chen; Xiujuan Wu; Yitao Duan; Dexian Zhi; Min Zou; Zhihong Zhao; Xiaojun Zhang; Xiaoang Yang; Jianying Zhang
Journal:  Oncol Lett       Date:  2019-05-27       Impact factor: 2.967

2.  Ursolic acid facilitates apoptosis in rheumatoid arthritis synovial fibroblasts by inducing SP1-mediated Noxa expression and proteasomal degradation of Mcl-1.

Authors:  Eugene Y Kim; Kuladeep Sudini; Anil K Singh; Mahamudul Haque; Douglas Leaman; Sadik Khuder; Salahuddin Ahmed
Journal:  FASEB J       Date:  2018-05-25       Impact factor: 5.191

3.  Ursolic acid activates the TGR5 receptor to enhance GLP-1 secretion in type 1-like diabetic rats.

Authors:  Shih-Hsiang Lo; Yingxiao Li; Kai Chun Cheng; Chiang-Shan Niu; Juei-Tang Cheng; Ho-Shan Niu
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2017-07-30       Impact factor: 3.000

4.  Synthesis and cytotoxic activity of novel A-ring cleaved ursolic acid derivatives in human non-small cell lung cancer cells.

Authors:  Vanessa I S Mendes; Geoffrey A Bartholomeusz; Mary Ayres; Varsha Gandhi; Jorge A R Salvador
Journal:  Eur J Med Chem       Date:  2016-07-22       Impact factor: 6.514

5.  Ursolic acid sensitized colon cancer cells to chemotherapy under hypoxia by inhibiting MDR1 through HIF-1α.

Authors:  Jian-Zhen Shan; Yan-Yan Xuan; Qi Zhang; Jian-Jin Huang
Journal:  J Zhejiang Univ Sci B       Date:  2016-09       Impact factor: 3.066

Review 6.  Anticancer effect of ursolic acid via mitochondria-dependent pathways.

Authors:  Xue-Min Feng; Xiu-Lan Su
Journal:  Oncol Lett       Date:  2019-03-19       Impact factor: 2.967

7.  A dual effect of ursolic acid to the treatment of multiple sclerosis through both immunomodulation and direct remyelination.

Authors:  Yuan Zhang; Xing Li; Bogoljub Ciric; Mark T Curtis; Wan-Jun Chen; Abdolmohamad Rostami; Guang-Xian Zhang
Journal:  Proc Natl Acad Sci U S A       Date:  2020-04-06       Impact factor: 11.205

8.  Ursolic acid promotes apoptosis and mediates transcriptional suppression of CT45A2 gene expression in non-small-cell lung carcinoma harbouring EGFR T790M mutations.

Authors:  Kaiyong Yang; Yan Chen; Jiaqian Zhou; Lin Ma; Yating Shan; Xiaoying Cheng; Yun Wang; Zhaoxin Zhang; Xiaojun Ji; Lili Chen; Hui Dai; Biqing Zhu; Chen Li; Zhonghua Tao; Xichun Hu; Wu Yin
Journal:  Br J Pharmacol       Date:  2019-12-26       Impact factor: 8.739

Review 9.  Molecular mechanisms of action of quercetin in cancer: recent advances.

Authors:  Dharambir Kashyap; Sonam Mittal; Katrin Sak; Paavan Singhal; Hardeep Singh Tuli
Journal:  Tumour Biol       Date:  2016-07-22

Review 10.  Molecular targets of gambogic acid in cancer: recent trends and advancements.

Authors:  Dharambir Kashyap; Rajkumar Mondal; Hardeep Singh Tuli; Gaurav Kumar; Anil K Sharma
Journal:  Tumour Biol       Date:  2016-07-22
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