Literature DB >> 27447983

Structures of the m(6)A Methyltransferase Complex: Two Subunits with Distinct but Coordinated Roles.

Katherine I Zhou1, Tao Pan2.   

Abstract

In this issue of Molecular Cell, Wang et al. (2016a) report crystal structures of the core of the METTL3/METTL14 m(6)A methyltransferase complex and propose how the two subunits interact and cooperate to bind and methylate RNA.
Copyright © 2016. Published by Elsevier Inc.

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Year:  2016        PMID： 27447983      PMCID： PMC5109923          DOI： 10.1016/j.molcel.2016.07.005

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  9 in total

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2.  Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons.

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3.  N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells.

Authors:  Yang Wang; Yue Li; Julia I Toth; Matthew D Petroski; Zhaolei Zhang; Jing Crystal Zhao
Journal:  Nat Cell Biol       Date:  2014-01-07       Impact factor: 28.824

4.  Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex.

Authors:  Xiang Wang; Jing Feng; Yuan Xue; Zeyuan Guan; Delin Zhang; Zhu Liu; Zhou Gong; Qiang Wang; Jinbo Huang; Chun Tang; Tingting Zou; Ping Yin
Journal:  Nature       Date:  2016-05-25       Impact factor: 49.962

5.  Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases.

Authors:  Ping Wang; Katelyn A Doxtader; Yunsun Nam
Journal:  Mol Cell       Date:  2016-06-30       Impact factor: 17.970

6.  N6-methyladenosine–encoded epitranscriptomics.

Authors:  Nian Liu; Tao Pan
Journal:  Nat Struct Mol Biol       Date:  2016-02       Impact factor: 15.369

Review 7.  RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation.

Authors:  Yanan Yue; Jianzhao Liu; Chuan He
Journal:  Genes Dev       Date:  2015-07-01       Impact factor: 11.361

8.  A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation.

Authors:  Jianzhao Liu; Yanan Yue; Dali Han; Xiao Wang; Ye Fu; Liang Zhang; Guifang Jia; Miao Yu; Zhike Lu; Xin Deng; Qing Dai; Weizhong Chen; Chuan He
Journal:  Nat Chem Biol       Date:  2013-12-06       Impact factor: 15.040

9.  Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq.

Authors:  Dan Dominissini; Sharon Moshitch-Moshkovitz; Schraga Schwartz; Mali Salmon-Divon; Lior Ungar; Sivan Osenberg; Karen Cesarkas; Jasmine Jacob-Hirsch; Ninette Amariglio; Martin Kupiec; Rotem Sorek; Gideon Rechavi
Journal:  Nature       Date:  2012-04-29       Impact factor: 49.962
  9 in total
  13 in total

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Journal:  Biomed Res Int       Date:  2020-02-29       Impact factor: 3.411

4.  METTL14 Inhibits Hepatocellular Carcinoma Metastasis Through Regulating EGFR/PI3K/AKT Signaling Pathway in an m6A-Dependent Manner.

Authors:  Yuntao Shi; Yingying Zhuang; Jialing Zhang; Mengxue Chen; Shangnong Wu
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Review 5.  Insights into N6-methyladenosine and programmed cell death in cancer.

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6.  The m6A epitranscriptome opens a new charter in immune system logic.

Authors:  Zhonghua Ma; Xiangyu Gao; You Shuai; Xiaofang Xing; Jiafu Ji
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7.  Enhancing Epitranscriptome Module Detection from m6A-Seq Data Using Threshold-Based Measurement Weighting Strategy.

Authors:  Kunqi Chen; Zhen Wei; Hui Liu; João Pedro de Magalhães; Rong Rong; Zhiliang Lu; Jia Meng
Journal:  Biomed Res Int       Date:  2018-06-14       Impact factor: 3.411

Review 8.  The potential role of RNA N6-methyladenosine in Cancer progression.

Authors:  Tianyi Wang; Shan Kong; Mei Tao; Shaoqing Ju
Journal:  Mol Cancer       Date:  2020-05-12       Impact factor: 27.401

9.  Analysis of METTL3 and METTL14 in hepatocellular carcinoma.

Authors:  Xiangxiang Liu; Jian Qin; Tianyi Gao; Chenmeng Li; Xiaoxiang Chen; Kaixuan Zeng; Mu Xu; Bangshun He; Bei Pan; Xueni Xu; Yuqin Pan; Huiling Sun; Tao Xu; Shukui Wang
Journal:  Aging (Albany NY)       Date:  2020-11-06       Impact factor: 5.682

Review 10.  Functions, mechanisms, and therapeutic implications of METTL14 in human cancer.

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