Navneet Singla1, Ankur Kapoor2, Debajyoti Chatterjee3, B D Radotra3. 1. Department of Neurosurgery, PGIMER Chandigarh, Chandigarh, 160012, India. 2. Department of Neurosurgery, PGIMER Chandigarh, Chandigarh, 160012, India. dr.ankurkapoor@gmail.com. 3. Department of Histopathology, PGIMER Chandigarh, Panchkula, India.
Abstract
BACKGROUND: Malignant rhabdoid tumor (MRT) is an aggressive tumor of infancy and childhood that rarely presents as a primary spinal or spinal cord tumor. There are only three reported cases of spinal MRT in infants. OBJECTIVE: We present a similar case in a 3-month male child who developed ultra-early recurrence, 4 weeks after complete excision. The diagnosis was confirmed by immunohistochemistry showing inactivation of the INI1 gene. RESULT: Despite surgical excision and adjuvant chemoradiotherapy, these tumors have a progressive course and recurrence is a common phenomenon. CONCLUSION: We believe that MRT must be considered in the differential diagnosis of the intra/paraspinal masses, especially in the infants.
BACKGROUND:Malignant rhabdoid tumor (MRT) is an aggressive tumor of infancy and childhood that rarely presents as a primary spinal or spinal cord tumor. There are only three reported cases of spinal MRT in infants. OBJECTIVE: We present a similar case in a 3-month male child who developed ultra-early recurrence, 4 weeks after complete excision. The diagnosis was confirmed by immunohistochemistry showing inactivation of the INI1 gene. RESULT: Despite surgical excision and adjuvant chemoradiotherapy, these tumors have a progressive course and recurrence is a common phenomenon. CONCLUSION: We believe that MRT must be considered in the differential diagnosis of the intra/paraspinal masses, especially in the infants.
Authors: D C Howlett; A P King; J M Jarosz; R A Stewart; S T al-Sarraj; J B Bingham; T C Cox Journal: Neuroradiology Date: 1997-10 Impact factor: 2.804
Authors: P C Burger; I T Yu; T Tihan; H S Friedman; D R Strother; J L Kepner; P K Duffner; L E Kun; E J Perlman Journal: Am J Surg Pathol Date: 1998-09 Impact factor: 6.394