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Literature DB >> 27444066

Amino Acid Sensing in Skeletal Muscle.

Tatiana Moro¹, Scott M Ebert², Christopher M Adams², Blake B Rasmussen³.

Abstract

Aging impairs skeletal muscle protein synthesis, leading to muscle weakness and atrophy. However, the underlying molecular mechanisms remain poorly understood. Here, we review evidence that mammalian/mechanistic target of rapamycin complex 1 (mTORC1)-mediated and activating transcription factor 4 (ATF4)-mediated amino acid (AA) sensing pathways, triggered by impaired AA delivery to aged skeletal muscle, may play important roles in skeletal muscle aging. Interventions that alleviate age-related impairments in muscle protein synthesis, strength, and/or muscle mass appear to do so by reversing age-related changes in skeletal muscle AA delivery, mTORC1 activity, and/or ATF4 activity. An improved understanding of the mechanisms and roles of AA sensing pathways in skeletal muscle may lead to evidence-based strategies to attenuate sarcopenia.

Entities: CellLine Chemical Disease Gene Species

Keywords: activating transcription factor 4; general control nonderepressible 2; leucine; mammalian/mechanistic target of rapamycin complex 1; tomatidine; ursolic acid

Mesh：

Substances：

Year: 2016 PMID： 27444066 PMCID： PMC5075248 DOI： 10.1016/j.tem.2016.06.010

Source DB: PubMed Journal: Trends Endocrinol Metab ISSN： 1043-2760 Impact factor: 12.015

67 in total

1. Bed rest impairs skeletal muscle amino acid transporter expression, mTORC1 signaling, and protein synthesis in response to essential amino acids in older adults.

Authors: Micah J Drummond; Jared M Dickinson; Christopher S Fry; Dillon K Walker; David M Gundermann; Paul T Reidy; Kyle L Timmerman; Melissa M Markofski; Douglas Paddon-Jones; Blake B Rasmussen; Elena Volpi
Journal: Am J Physiol Endocrinol Metab Date: 2012-02-14 Impact factor: 4.310

2. Aerobic exercise overcomes the age-related insulin resistance of muscle protein metabolism by improving endothelial function and Akt/mammalian target of rapamycin signaling.

Authors: Satoshi Fujita; Blake B Rasmussen; Jerson G Cadenas; Micah J Drummond; Erin L Glynn; Fred R Sattler; Elena Volpi
Journal: Diabetes Date: 2007-03-09 Impact factor: 9.461

3. Skeletal muscle amino acid transporter expression is increased in young and older adults following resistance exercise.

Authors: Micah J Drummond; Christopher S Fry; Erin L Glynn; Kyle L Timmerman; Jared M Dickinson; Dillon K Walker; David M Gundermann; Elena Volpi; Blake B Rasmussen
Journal: J Appl Physiol (1985) Date: 2011-04-28

4. Essential amino acids are primarily responsible for the amino acid stimulation of muscle protein anabolism in healthy elderly adults.

Authors: Elena Volpi; Hisamine Kobayashi; Melinda Sheffield-Moore; Bettina Mittendorfer; Robert R Wolfe
Journal: Am J Clin Nutr Date: 2003-08 Impact factor: 7.045

Review 5. Regulation of muscle protein synthesis and the effects of catabolic states.

Authors: Bradley S Gordon; Andrew R Kelleher; Scot R Kimball
Journal: Int J Biochem Cell Biol Date: 2013-06-12 Impact factor: 5.085

6. Insulin resistance of muscle protein metabolism in aging.

Authors: Blake B Rasmussen; Satoshi Fujita; Robert R Wolfe; Bettina Mittendorfer; Mona Roy; Vincent L Rowe; Elena Volpi
Journal: FASEB J Date: 2006-02-07 Impact factor: 5.191

7. Amino acid infusion fails to stimulate skeletal muscle protein synthesis up to 1 year after injury in children with severe burns.

Authors: Craig Porter; Matthew Cotter; Eva C Diaz; Kristofer Jennings; David N Herndon; Elisabet Børsheim
Journal: J Trauma Acute Care Surg Date: 2013-06 Impact factor: 3.313

8. Two weeks of reduced activity decreases leg lean mass and induces "anabolic resistance" of myofibrillar protein synthesis in healthy elderly.

Authors: Leigh Breen; Keith A Stokes; Tyler A Churchward-Venne; Daniel R Moore; Stephen K Baker; Kenneth Smith; Philip J Atherton; Stuart M Phillips
Journal: J Clin Endocrinol Metab Date: 2013-04-15 Impact factor: 5.958

9. Ursolic Acid-induced elevation of serum irisin augments muscle strength during resistance training in men.

Authors: Hyun Seok Bang; Dae Yun Seo; Yong Min Chung; Kyoung-Mo Oh; Jung Jun Park; Figueroa Arturo; Seung-Hun Jeong; Nari Kim; Jin Han
Journal: Korean J Physiol Pharmacol Date: 2014-10-17 Impact factor: 2.016

10. Dietary protein distribution positively influences 24-h muscle protein synthesis in healthy adults.

Authors: Madonna M Mamerow; Joni A Mettler; Kirk L English; Shanon L Casperson; Emily Arentson-Lantz; Melinda Sheffield-Moore; Donald K Layman; Douglas Paddon-Jones
Journal: J Nutr Date: 2014-01-29 Impact factor: 4.798

29 in total

1. Muscle Protein Anabolic Resistance to Essential Amino Acids Does Not Occur in Healthy Older Adults Before or After Resistance Exercise Training.

Authors: Tatiana Moro; Camille R Brightwell; Rachel R Deer; Ted G Graber; Elfego Galvan; Christopher S Fry; Elena Volpi; Blake B Rasmussen
Journal: J Nutr Date: 2018-06-01 Impact factor: 4.798

Review 2. The Importance of Resistance Exercise Training to Combat Neuromuscular Aging.

Authors: Kaleen M Lavin; Brandon M Roberts; Christopher S Fry; Tatiana Moro; Blake B Rasmussen; Marcas M Bamman
Journal: Physiology (Bethesda) Date: 2019-03-01

3. The muscle anabolic effect of protein ingestion during a hyperinsulinaemic euglycaemic clamp in middle-aged women is not caused by leucine alone.

Authors: Stephan van Vliet; Gordon I Smith; Lane Porter; Raja Ramaswamy; Dominic N Reeds; Adewole L Okunade; Jun Yoshino; Samuel Klein; Bettina Mittendorfer
Journal: J Physiol Date: 2018-08-29 Impact factor: 5.182

Amino Acid Sensing in Skeletal Muscle.

1. Bed rest impairs skeletal muscle amino acid transporter expression, mTORC1 signaling, and protein synthesis in response to essential amino acids in older adults.

2. Aerobic exercise overcomes the age-related insulin resistance of muscle protein metabolism by improving endothelial function and Akt/mammalian target of rapamycin signaling.

3. Skeletal muscle amino acid transporter expression is increased in young and older adults following resistance exercise.

4. Essential amino acids are primarily responsible for the amino acid stimulation of muscle protein anabolism in healthy elderly adults.

Review 5. Regulation of muscle protein synthesis and the effects of catabolic states.

6. Insulin resistance of muscle protein metabolism in aging.

7. Amino acid infusion fails to stimulate skeletal muscle protein synthesis up to 1 year after injury in children with severe burns.

8. Two weeks of reduced activity decreases leg lean mass and induces "anabolic resistance" of myofibrillar protein synthesis in healthy elderly.

9. Ursolic Acid-induced elevation of serum irisin augments muscle strength during resistance training in men.

10. Dietary protein distribution positively influences 24-h muscle protein synthesis in healthy adults.

1. Muscle Protein Anabolic Resistance to Essential Amino Acids Does Not Occur in Healthy Older Adults Before or After Resistance Exercise Training.

Review 2. The Importance of Resistance Exercise Training to Combat Neuromuscular Aging.

3. The muscle anabolic effect of protein ingestion during a hyperinsulinaemic euglycaemic clamp in middle-aged women is not caused by leucine alone.

4. Resistance exercise training promotes fiber type-specific myonuclear adaptations in older adults.

5. Mechanisms Underlying Muscle Protein Imbalance Induced by Alcohol.

6. Post-absorptive muscle protein turnover affects resistance training hypertrophy.

Review 7. Sarcopenia, Aging and Prospective Interventional Strategies.

Review 8. Amino acids and amino acid sensing: implication for aging and diseases.

9. ATF4 Is a Fundamental Regulator of Nutrient Sensing and Protein Turnover.

Review 10. Nutritional Support for Bariatric Surgery Patients: The Skin beyond the Fat.