Literature DB >> 27443612

Whole-Genome Sequencing to Evaluate the Resistance Landscape Following Antimalarial Treatment Failure With Fosmidomycin-Clindamycin.

Ann M Guggisberg1, Sesh A Sundararaman2, Miguel Lanaspa3, Cinta Moraleda3, Raquel González3, Alfredo Mayor3, Pau Cisteró4, David Hutchinson5, Peter G Kremsner6, Beatrice H Hahn2, Quique Bassat7, Audrey R Odom8.   

Abstract

Novel antimalarial therapies are needed in the face of emerging resistance to artemisinin combination therapies. A previous study found a high cure rate in Mozambican children with uncomplicated Plasmodium falciparum malaria 7 days after combination treatment with fosmidomycin-clindamycin. However, 28-day cure rates were low (45.9%), owing to parasite recrudescence. We sought to identify any genetic changes underlying parasite recrudescence. To this end, we used a selective whole-genome amplification method to amplify parasite genomes from blood spot DNA samples. Parasite genomes from pretreatment and postrecrudescence samples were subjected to whole-genome sequencing to identify nucleotide variants. Our data did not support the existence of a genetic change responsible for recrudescence following fosmidomycin-clindamycin treatment. Additionally, we found that previously described resistance alleles for these drugs do not represent biomarkers of recrudescence. Future studies should continue to optimize fosmidomycin combinations for use as antimalarial therapies.
© The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.

Entities:  

Keywords:  Malaria; Plasmodium; clindamycin; fosmidomycin; recrudescence; whole genome amplification

Mesh：

Substances：

Year:  2016        PMID： 27443612      PMCID： PMC5021231          DOI： 10.1093/infdis/jiw304

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  47 in total

1.  Inadequate efficacy of a new formulation of fosmidomycin-clindamycin combination in Mozambican children less than three years old with uncomplicated Plasmodium falciparum malaria.

Authors:  Miguel Lanaspa; Cinta Moraleda; Sónia Machevo; Raquel González; Beatriz Serrano; Eusebio Macete; Pau Cisteró; Alfredo Mayor; David Hutchinson; Peter G Kremsner; Pedro Alonso; Clara Menéndez; Quique Bassat
Journal:  Antimicrob Agents Chemother       Date:  2012-03-19       Impact factor: 5.191

2.  Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria.

Authors:  D S Peterson; D Walliker; T E Wellems
Journal:  Proc Natl Acad Sci U S A       Date:  1988-12       Impact factor: 11.205

3.  Spiroindolones, a potent compound class for the treatment of malaria.

Authors:  Matthias Rottmann; Case McNamara; Bryan K S Yeung; Marcus C S Lee; Bin Zou; Bruce Russell; Patrick Seitz; David M Plouffe; Neekesh V Dharia; Jocelyn Tan; Steven B Cohen; Kathryn R Spencer; Gonzalo E González-Páez; Suresh B Lakshminarayana; Anne Goh; Rossarin Suwanarusk; Timothy Jegla; Esther K Schmitt; Hans-Peter Beck; Reto Brun; Francois Nosten; Laurent Renia; Veronique Dartois; Thomas H Keller; David A Fidock; Elizabeth A Winzeler; Thierry T Diagana
Journal:  Science       Date:  2010-09-03       Impact factor: 47.728

4.  (+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium.

Authors:  María Belén Jiménez-Díaz; Daniel Ebert; Yandira Salinas; Anupam Pradhan; Adele M Lehane; Marie-Eve Myrand-Lapierre; Kathleen G O'Loughlin; David M Shackleford; Mariana Justino de Almeida; Angela K Carrillo; Julie A Clark; Adelaide S M Dennis; Jonathon Diep; Xiaoyan Deng; Sandra Duffy; Aaron N Endsley; Greg Fedewa; W Armand Guiguemde; María G Gómez; Gloria Holbrook; Jeremy Horst; Charles C Kim; Jian Liu; Marcus C S Lee; Amy Matheny; María Santos Martínez; Gregory Miller; Ane Rodríguez-Alejandre; Laura Sanz; Martina Sigal; Natalie J Spillman; Philip D Stein; Zheng Wang; Fangyi Zhu; David Waterson; Spencer Knapp; Anang Shelat; Vicky M Avery; David A Fidock; Francisco-Javier Gamo; Susan A Charman; Jon C Mirsalis; Hongshen Ma; Santiago Ferrer; Kiaran Kirk; Iñigo Angulo-Barturen; Dennis E Kyle; Joseph L DeRisi; David M Floyd; R Kiplin Guy
Journal:  Proc Natl Acad Sci U S A       Date:  2014-12-01       Impact factor: 11.205

5.  A second target of the antimalarial and antibacterial agent fosmidomycin revealed by cellular metabolic profiling.

Authors:  Baichen Zhang; Kristin M Watts; Dana Hodge; Lisa M Kemp; David A Hunstad; Leslie M Hicks; Audrey R Odom
Journal:  Biochemistry       Date:  2011-04-11       Impact factor: 3.162

6.  Molecular analysis of Plasmodium falciparum recrudescent malaria infections in children treated with chloroquine in Nigeria.

Authors:  C T Happi; G O Gbotosho; A Sowunmi; C O Falade; D O Akinboye; L Gerena; D E Kyle; W Milhous; D F Wirth; A M J Oduola
Journal:  Am J Trop Med Hyg       Date:  2004-01       Impact factor: 2.345

7.  Fosmidomycin-clindamycin for the treatment of Plasmodium falciparum malaria.

Authors:  Steffen Borrmann; Saadou Issifou; Gilbert Esser; Ayola A Adegnika; Michael Ramharter; Pierre-Blaise Matsiegui; Sunny Oyakhirome; Dénise P Mawili-Mboumba; Michel A Missinou; Jürgen F J Kun; Hassan Jomaa; Peter G Kremsner
Journal:  J Infect Dis       Date:  2004-09-21       Impact factor: 5.226

8.  Spread of artemisinin resistance in Plasmodium falciparum malaria.

Authors:  Elizabeth A Ashley; Mehul Dhorda; Rick M Fairhurst; Chanaki Amaratunga; Parath Lim; Seila Suon; Sokunthea Sreng; Jennifer M Anderson; Sivanna Mao; Baramey Sam; Chantha Sopha; Char Meng Chuor; Chea Nguon; Siv Sovannaroth; Sasithon Pukrittayakamee; Podjanee Jittamala; Kesinee Chotivanich; Kitipumi Chutasmit; Chaiyaporn Suchatsoonthorn; Ratchadaporn Runcharoen; Tran Tinh Hien; Nguyen Thanh Thuy-Nhien; Ngo Viet Thanh; Nguyen Hoan Phu; Ye Htut; Kay-Thwe Han; Kyin Hla Aye; Olugbenga A Mokuolu; Rasaq R Olaosebikan; Olaleke O Folaranmi; Mayfong Mayxay; Maniphone Khanthavong; Bouasy Hongvanthong; Paul N Newton; Marie A Onyamboko; Caterina I Fanello; Antoinette K Tshefu; Neelima Mishra; Neena Valecha; Aung Pyae Phyo; Francois Nosten; Poravuth Yi; Rupam Tripura; Steffen Borrmann; Mahfudh Bashraheil; Judy Peshu; M Abul Faiz; Aniruddha Ghose; M Amir Hossain; Rasheda Samad; M Ridwanur Rahman; M Mahtabuddin Hasan; Akhterul Islam; Olivo Miotto; Roberto Amato; Bronwyn MacInnis; Jim Stalker; Dominic P Kwiatkowski; Zbynek Bozdech; Atthanee Jeeyapant; Phaik Yeong Cheah; Tharisara Sakulthaew; Jeremy Chalk; Benjamas Intharabut; Kamolrat Silamut; Sue J Lee; Benchawan Vihokhern; Chanon Kunasol; Mallika Imwong; Joel Tarning; Walter J Taylor; Shunmay Yeung; Charles J Woodrow; Jennifer A Flegg; Debashish Das; Jeffery Smith; Meera Venkatesan; Christopher V Plowe; Kasia Stepniewska; Philippe J Guerin; Arjen M Dondorp; Nicholas P Day; Nicholas J White
Journal:  N Engl J Med       Date:  2014-07-31       Impact factor: 91.245

9.  Limited polymorphisms in k13 gene in Plasmodium falciparum isolates from Dakar, Senegal in 2012-2013.

Authors:  Marylin Torrentino-Madamet; Bécaye Fall; Nicolas Benoit; Cheikhou Camara; Rémy Amalvict; Mansour Fall; Pierre Dionne; Kadidiatou Ba Fall; Aminata Nakoulima; Bakary Diatta; Yaya Diemé; Didier Ménard; Boubacar Wade; Bruno Pradines
Journal:  Malar J       Date:  2014-12-04       Impact factor: 2.979

10.  Genome-wide analysis of selection on the malaria parasite Plasmodium falciparum in West African populations of differing infection endemicity.

Authors:  Victor A Mobegi; Craig W Duffy; Alfred Amambua-Ngwa; Kovana M Loua; Eugene Laman; Davis C Nwakanma; Bronwyn MacInnis; Harvey Aspeling-Jones; Lee Murray; Taane G Clark; Dominic P Kwiatkowski; David J Conway
Journal:  Mol Biol Evol       Date:  2014-03-18       Impact factor: 16.240
View more
  13 in total

1.  Finding the needle in the haystack.

Authors:  Gavin G Rutledge; Cristina V Ariani
Journal:  Nat Rev Microbiol       Date:  2017-02-13       Impact factor: 60.633

2.  swga: a primer design toolkit for selective whole genome amplification.

Authors:  Erik L Clarke; Sesh A Sundararaman; Stephanie N Seifert; Frederic D Bushman; Beatrice H Hahn; Dustin Brisson
Journal:  Bioinformatics       Date:  2017-07-15       Impact factor: 6.937

3.  Proteome size reduction in Apicomplexans is linked with loss of DNA repair and host redundant pathways.

Authors:  D Derilus; M Z Rahman; A E Serrano; S E Massey
Journal:  Infect Genet Evol       Date:  2020-12-06       Impact factor: 3.342

4.  Whole genome sequencing of Plasmodium falciparum from dried blood spots using selective whole genome amplification.

Authors:  Samuel O Oyola; Cristina V Ariani; William L Hamilton; Mihir Kekre; Lucas N Amenga-Etego; Anita Ghansah; Gavin G Rutledge; Seth Redmond; Magnus Manske; Dushyanth Jyothi; Chris G Jacob; Thomas D Otto; Kirk Rockett; Chris I Newbold; Matthew Berriman; Dominic P Kwiatkowski
Journal:  Malar J       Date:  2016-12-20       Impact factor: 2.979

5.  Selective Whole-Genome Amplification Is a Robust Method That Enables Scalable Whole-Genome Sequencing of Plasmodium vivax from Unprocessed Clinical Samples.

Authors:  Annie N Cowell; Dorothy E Loy; Sesh A Sundararaman; Hugo Valdivia; Kathleen Fisch; Andres G Lescano; G Christian Baldeviano; Salomon Durand; Vince Gerbasi; Colin J Sutherland; Debbie Nolder; Joseph M Vinetz; Beatrice H Hahn; Elizabeth A Winzeler
Journal:  mBio       Date:  2017-02-07       Impact factor: 7.867

6.  Small molecule inhibition of apicomplexan FtsH1 disrupts plastid biogenesis in human pathogens.

Authors:  Katherine Amberg-Johnson; Sanjay B Hari; Suresh M Ganesan; Hernan A Lorenzi; Robert T Sauer; Jacquin C Niles; Ellen Yeh
Journal:  Elife       Date:  2017-08-18       Impact factor: 8.140

7.  Efficacy and Safety of Fosmidomycin-Piperaquine as Nonartemisinin-Based Combination Therapy for Uncomplicated Falciparum Malaria: A Single-Arm, Age De-escalation Proof-of-Concept Study in Gabon.

Authors:  Ghyslain Mombo-Ngoma; Jonathan Remppis; Moritz Sievers; Rella Zoleko Manego; Lilian Endamne; Lumeka Kabwende; Luzia Veletzky; The Trong Nguyen; Mirjam Groger; Felix Lötsch; Johannes Mischlinger; Lena Flohr; Johanna Kim; Chiara Cattaneo; David Hutchinson; Stephan Duparc; Joerg Moehrle; Thirumalaisamy P Velavan; Bertrand Lell; Michael Ramharter; Ayola Akim Adegnika; Benjamin Mordmüller; Peter G Kremsner
Journal:  Clin Infect Dis       Date:  2018-06-01       Impact factor: 9.079

8.  Genetic mapping of fitness determinants across the malaria parasite Plasmodium falciparum life cycle.

Authors:  Xue Li; Sudhir Kumar; Marina McDew-White; Meseret Haile; Ian H Cheeseman; Scott Emrich; Katie Button-Simons; François Nosten; Stefan H I Kappe; Michael T Ferdig; Tim J C Anderson; Ashley M Vaughan
Journal:  PLoS Genet       Date:  2019-10-14       Impact factor: 5.917

9.  Diversity and Within-Host Evolution of Leishmania donovani from Visceral Leishmaniasis Patients with and without HIV Coinfection in Northern Ethiopia.

Authors:  Susanne U Franssen; Yegnasew Takele; Emebet Adem; Mandy J Sanders; Ingrid Müller; Pascale Kropf; James A Cotton
Journal:  mBio       Date:  2021-06-29       Impact factor: 7.867

10.  Direct whole-genome sequencing of Plasmodium falciparum specimens from dried erythrocyte spots.

Authors:  Sidsel Nag; Poul-Erik Kofoed; Johan Ursing; Camilla Koldbæk Lemvigh; Rosa Lundbye Allesøe; Amabelia Rodrigues; Christina Aaby Svendsen; Jacob Dyring Jensen; Michael Alifrangis; Ole Lund; Frank M Aarestrup
Journal:  Malar J       Date:  2018-02-23       Impact factor: 2.979
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.