Literature DB >> 2744043

A patient with infantile spasms and low homovanillic acid levels in cerebrospinal fluid: L-dopa dependent seizures?

H Sugie1, Y Sugie, N Kato, Y Fukuyama.   

Abstract

We report a 3-month-old female with infantile spasms that responded transiently to pyridoxine and permanently to oral L-dopa. Initial CSF levels of homovanillic acid were low, suggesting disturbed turnover of dopamine. These findings suggest that disturbed brain monoamine metabolism may be causally related to infantile spasms.

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Year:  1989        PMID： 2744043     DOI： 10.1007/bf00441530

Source DB:  PubMed          Journal:  Eur J Pediatr        ISSN： 0340-6199            Impact factor:   3.183


  6 in total

1.  [Quantitative analysis of catecholamine and serotonin metabolites on thin-layer plates. II. Reflectance measurements after a specific photochemical reaction].

Authors:  H Huck; E Dworzak
Journal:  J Chromatogr       Date:  1972-12-20

2.  Infantile spasms associated with 5-hydroxytryptophan administration in patients with Down's syndrome.

Authors:  M Coleman
Journal:  Neurology       Date:  1971-09       Impact factor: 9.910

3.  Reduced cerebrospinal fluid 5-hydroxyindoleacetic acid and homovanillic acid in children with epilepsy.

Authors:  B A Shaywitz; D J Cohen; M B Bowers
Journal:  Neurology       Date:  1975-01       Impact factor: 9.910

4.  Cerebrospinal fluid monoamine metabolites in patients with infantile spasms.

Authors:  F Silverstein; M V Johnston
Journal:  Neurology       Date:  1984-01       Impact factor: 9.910

5.  Elevated homovanillic acid in cerebrospinal fluid of children with infantile spasms.

Authors:  M Ito; T Okuno; H Mikawa; Y Osumi
Journal:  Epilepsia       Date:  1980-08       Impact factor: 5.864

6.  High dose B6 treatment in infantile spasms.

Authors:  G Blennow; L Starck
Journal:  Neuropediatrics       Date:  1986-02       Impact factor: 1.947
  6 in total
  2 in total

Review 1.  Abnormalities of biogenic amine metabolism.

Authors:  K Hyland
Journal:  J Inherit Metab Dis       Date:  1993       Impact factor: 4.982

2.  ACTH and PMX53 recover synaptic transcriptome alterations in a rat model of infantile spasms.

Authors:  Dumitru A Iacobaş; Tamar Chachua; Sanda Iacobaş; Melissa J Benson; Karin Borges; Jana Velíšková; Libor Velíšek
Journal:  Sci Rep       Date:  2018-04-10       Impact factor: 4.379
  2 in total

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