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Literature DB >> 27431401

Computational pharmacokinetic rationale for intra-arterial delivery to the brain.

Johann N R Cooke¹, Jason A Ellis², Shaolie Hossain^3,4, Juliane Nguyen⁵, Jeffrey N Bruce², Shailendra Joshi⁶.

Abstract

Intra-arterial (IA) drug delivery has been proposed for the treatment of a wide range of brain diseases, including malignant brain tumors. However, pharmacokinetic optimization for IA drug delivery to the brain remains a challenge. In this report, we apply and expand the well-established Dedrick model of IA drug delivery to the brain and test the effects of modifying drug and delivery parameters. These simulations show that altering the properties of candidate drugs and physiological variables can have profound effects on regional deposition after IA injections. We show that drug and physiological optimization aimed at rapid drug extraction and sustained retention is necessary to maximize regional deposition after of IA injections.

Entities: Disease

Keywords: Blood-brain barrier; Brain tumor; Chemotherapy; Glioma

Mesh：

Substances：
Antineoplastic Agents

Year: 2016 PMID： 27431401 DOI： 10.1007/s13346-016-0319-6

Source DB: PubMed Journal: Drug Deliv Transl Res ISSN： 2190-393X Impact factor: 4.617

25 in total

1. Reducing cerebral blood flow increases the duration of electroencephalographic silence by intracarotid thiopental.

Authors: Shailendra Joshi; Mei Wang; Joshua J Etu; John Pile-Spellman
Journal: Anesth Analg Date: 2005-09 Impact factor: 5.108

Review 2. Strategies to advance translational research into brain barriers.

Authors: Edward Neuwelt; N Joan Abbott; Lauren Abrey; William A Banks; Brian Blakley; Thomas Davis; Britta Engelhardt; Paula Grammas; Maiken Nedergaard; John Nutt; William Pardridge; Gary A Rosenberg; Quentin Smith; Lester R Drewes
Journal: Lancet Neurol Date: 2008-01 Impact factor: 44.182

2. Targeting brain tumors by intra-arterial delivery of cell-penetrating peptides: a novel approach for primary and metastatic brain malignancy.

Authors: Shailendra Joshi; Johann R N Cooke; Jason A Ellis; Charles W Emala; Jeffrey N Bruce
Journal: J Neurooncol Date: 2017-09-05 Impact factor: 4.130

2 in total

Computational pharmacokinetic rationale for intra-arterial delivery to the brain.

1. Reducing cerebral blood flow increases the duration of electroencephalographic silence by intracarotid thiopental.

Review 2. Strategies to advance translational research into brain barriers.

3. Nanoparticles and toxicity in therapeutic delivery: the ongoing debate.

4. Cationizable lipid micelles as vehicles for intraarterial glioma treatment.

Review 5. Arterial drug infusion: pharmacokinetic problems and pitfalls.

6. Brain uptake of benzodiazepines: effects of lipophilicity and plasma protein binding.

7. In nonhuman primates intracarotid adenosine, but not sodium nitroprusside, increases cerebral blood flow.

8. Pharmacokinetic model-predicted anticancer drug concentrations in human tumors.

9. The feasibility of intracarotid adenosine for the manipulation of human cerebrovascular resistance.

10. Transient cerebral hypoperfusion enhances intraarterial carmustine deposition into brain tissue.

1. Flow arrest intra-arterial delivery of small TAT-decorated and neutral micelles to gliomas.

2. Targeting brain tumors by intra-arterial delivery of cell-penetrating peptides: a novel approach for primary and metastatic brain malignancy.