Filgen Fung1, Sylvie D Cornacchi1, Thuva Vanniyasingam2, Dyda Dao1, Lehana Thabane2, Marko Simunovic3, Nicole Hodgson3, Mary Ann O'Brien4, Susan Reid3, Barbara Heller3, Peter J Lovrics5. 1. Department of Surgery, McMaster University, St. Joseph's Healthcare Hamilton, 50 Charlton Avenue East, Hamilton, Ontario L8N 4A6, Canada. 2. Department of Clinical Epidemiology and Biostatistics, McMaster University and Biostatistics Unit, St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada. 3. Department of Surgery, McMaster University, St. Joseph's Healthcare Hamilton, 50 Charlton Avenue East, Hamilton, Ontario L8N 4A6, Canada; Department of Surgical Oncology, Hamilton Health Sciences, Juravinski Hospital and Cancer Centre, 699 Concession Street, Hamilton, Ontario, L8V 5C2, Canada. 4. Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada. 5. Department of Surgery, McMaster University, St. Joseph's Healthcare Hamilton, 50 Charlton Avenue East, Hamilton, Ontario L8N 4A6, Canada; Department of Surgical Oncology, Hamilton Health Sciences, Juravinski Hospital and Cancer Centre, 699 Concession Street, Hamilton, Ontario, L8V 5C2, Canada. Electronic address: lovricsp@mcmaster.ca.
Abstract
BACKGROUND: The study purpose was to identify tumor and surgeon predictors of local recurrence (LR), regional recurrence (RR), and distant metastasis (DM) after breast cancer (BC) surgery in a population-based cohort. METHODS: Consecutive BC surgical cases from 12 hospitals in South Central Ontario between May 2006 and October 2006 were included. Data collected on chart review included patient and tumor factors, surgery type, adjuvant treatment, surgeon specialty, surgeon case volume, and practice type. Univariate and multivariable survival analyses were performed. RESULTS: Median follow-up was 5.5 years for 402 patients (97% of sample). LR, RR, and DM occurred in 18 (4.5%), 10 (2.5%), and 47 (12%) patients, respectively. Significant predictors of BC recurrence (LR or RR or DM) were tumor size and grade, nodal status, and lymphovascular invasion on multivariable analysis. CONCLUSION: Tumor factors such as size, grade, lymphovascular invasion, and nodal status predicted BC recurrence, while practice type, surgeon specialty, and case volume did not.
BACKGROUND: The study purpose was to identify tumor and surgeon predictors of local recurrence (LR), regional recurrence (RR), and distant metastasis (DM) after breast cancer (BC) surgery in a population-based cohort. METHODS: Consecutive BC surgical cases from 12 hospitals in South Central Ontario between May 2006 and October 2006 were included. Data collected on chart review included patient and tumor factors, surgery type, adjuvant treatment, surgeon specialty, surgeon case volume, and practice type. Univariate and multivariable survival analyses were performed. RESULTS: Median follow-up was 5.5 years for 402 patients (97% of sample). LR, RR, and DM occurred in 18 (4.5%), 10 (2.5%), and 47 (12%) patients, respectively. Significant predictors of BC recurrence (LR or RR or DM) were tumor size and grade, nodal status, and lymphovascular invasion on multivariable analysis. CONCLUSION:Tumor factors such as size, grade, lymphovascular invasion, and nodal status predicted BC recurrence, while practice type, surgeon specialty, and case volume did not.
Authors: Q Zheng; X Cui; D Zhang; Y Yang; X Yan; M Liu; B Niang; F Aziz; S Liu; Q Yan; J Liu Journal: Oncogenesis Date: 2017-07-10 Impact factor: 7.485