Chelvin Sng1, Keith Barton2, Hanna Kim3, Shi Yuan4, Donald L Budenz5. 1. Glaucoma Service and National Institute for Health Research Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital, London, United Kingdom; Department of Ophthalmology, National University Health System, Singapore; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore. 2. Glaucoma Service and National Institute for Health Research Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital, London, United Kingdom; Department of Epidemiology and Genetics, Institute of Ophthalmology, University College London, London, United Kingdom. Electronic address: keith@keithbarton.co.uk. 3. Department of Ophthalmology, Kaiser Permanente, Woodland Hills, California. 4. Singapore Eye Research Institute, Singapore National Eye Centre, Singapore. 5. Department of Ophthalmology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Abstract
PURPOSE: To assess the associations of central corneal thickness (CCT) with ocular and systemic factors in a West African population. DESIGN: Population-based cross-sectional study. METHODS: Participants aged ≥40 years in the Tema Eye Survey who had clinically normal corneas were included in this study. CCT was determined bilaterally using handheld ultrasound pachymetry. The association between CCT and ocular or systemic factors was analyzed with univariable linear regression. Multivariable linear regression analysis was performed for variables significantly associated with CCT in the univariable analysis. Main outcome measures were CCT (μm) and its associations with age, sex, IOP, cup-to-disc ratio (CDR), glaucoma, hypertension, and diabetes. RESULTS: A total of 6806 eligible subjects were identified, of whom 5603 (82.3%) participated in the Tema Eye Survey. A total of 4737 participants (84.5% of participants) of West African descent and clinically normal corneas were included. The mean age ± standard deviation (SD) of participants was 51.2 ± 9.7 years and 38.7% were male. The mean ± SD CCT in the population was 533.9 ± 34.0 μm. In the multivariable linear regression analysis, increased CCT was significantly associated with younger age, male sex, and higher IOP (all P < .001). There were no significant associations between CCT and CDR, glaucoma, hypertension, and diabetes. CONCLUSIONS: This population-based cross-sectional survey of West African adults found a significant association between increased CCT and younger age, male sex, and higher IOP but not glaucoma or CDR. Variations in corneal thickness may influence the accuracy of IOP measurements in African persons. Crown
PURPOSE: To assess the associations of central corneal thickness (CCT) with ocular and systemic factors in a West African population. DESIGN: Population-based cross-sectional study. METHODS:Participants aged ≥40 years in the Tema Eye Survey who had clinically normal corneas were included in this study. CCT was determined bilaterally using handheld ultrasound pachymetry. The association between CCT and ocular or systemic factors was analyzed with univariable linear regression. Multivariable linear regression analysis was performed for variables significantly associated with CCT in the univariable analysis. Main outcome measures were CCT (μm) and its associations with age, sex, IOP, cup-to-disc ratio (CDR), glaucoma, hypertension, and diabetes. RESULTS: A total of 6806 eligible subjects were identified, of whom 5603 (82.3%) participated in the Tema Eye Survey. A total of 4737 participants (84.5% of participants) of West African descent and clinically normal corneas were included. The mean age ± standard deviation (SD) of participants was 51.2 ± 9.7 years and 38.7% were male. The mean ± SD CCT in the population was 533.9 ± 34.0 μm. In the multivariable linear regression analysis, increased CCT was significantly associated with younger age, male sex, and higher IOP (all P < .001). There were no significant associations between CCT and CDR, glaucoma, hypertension, and diabetes. CONCLUSIONS: This population-based cross-sectional survey of West African adults found a significant association between increased CCT and younger age, male sex, and higher IOP but not glaucoma or CDR. Variations in corneal thickness may influence the accuracy of IOP measurements in African persons. Crown